Search Results - "LITTLE, DIANNE"

Synthetic scaffolds for musculoskeletal tissue engineering: cellular responses to fiber parameters by Jenkins, Thomas Lee, Little, Dianne

“…Tissue engineering often uses synthetic scaffolds to direct cell responses during engineered tissue development. Since cells reside within specific niches of…”
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Tendon mechanobiology: Current knowledge and future research opportunities by Lavagnino, Michael, Wall, Michelle E., Little, Dianne, Banes, Albert J., Guilak, Farshid, Arnoczky, Steven P.

“…ABSTRACT Tendons mainly function as load‐bearing tissues in the muscloskeletal system; transmitting loads from muscle to bone. Tendons are dynamic structures…”
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TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension by Gilchrist, Christopher L., Leddy, Holly A., Kaye, Laurel, Case, Natasha D., Rothenberg, Katheryn E., Little, Dianne, Liedtke, Wolfgang, Hoffman, Brenton D., Guilak, Farshid

“…Microarchitectural cues drive aligned fibrillar collagen deposition in vivo and in biomaterial scaffolds, but the cell-signaling events that underlie this…”
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Tendon and multiomics: advantages, advances, and opportunities by Sarmiento, Paula, Little, Dianne

“…Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not…”
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Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis by O’Conor, Christopher J., Ramalingam, Sendhilnathan, Zelenski, Nicole A., Benefield, Halei C., Rigo, Isaura, Little, Dianne, Wu, Chia-Lung, Chen, Di, Liedtke, Wolfgang, McNulty, Amy L., Guilak, Farshid

“…Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and surrounding tissues, and is associated with both advanced age and joint…”
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Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis by Kimmerling, Kelly A, Oswald, Sara J, Huebner, Janet L, Little, Dianne, Kraus, Virginia B, Kang, Jing X, Wu, Chia-Lung, Guilak, Farshid

“…Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic…”
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Proteomic differences between male and female anterior cruciate ligament and patellar tendon by Little, Dianne, Thompson, J Will, Dubois, Laura G, Ruch, David S, Moseley, M Arthur, Guilak, Farshid

“…The risk of anterior cruciate ligament (ACL) injury and re-injury is greater for women than men. Among other factors, compositional differences may play a role…”
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Biological resurfacing in a canine model of hip osteoarthritis by Estes, Bradley T, Enomoto, Masataka, Moutos, Franklin T, Carson, Megan A, Toth, Jeffrey M, Eggert, Peter, Stallrich, Jonathan, Willard, Vincent P, Veis, Deborah J, Little, Dianne, Guilak, Farshid, Lascelles, B Duncan X

“…Articular cartilage has unique load-bearing properties but has minimal capacity for intrinsic repair. Here, we used three-dimensional weaving, additive…”
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The role of the anterior shoulder joint capsule in primary glenohumeral osteoarthritis by Sudah, Suleiman Y., Menendez, Mariano E., Moverman, Michael A., Puzzitiello, Richard N., Little, Dianne, Nicholson, Allen D., Garrigues, Grant E.

“…The pathogenesis of primary glenohumeral arthritis (GHOA) is mediated by a complex interaction between osseous anatomy and the surrounding soft tissues…”
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ICV leptin effects on spontaneous physical activity and feeding behavior in rats by Choi, Yang-Ho, Li, ChangLong, Hartzell, Diane L., Little, Dianne E., Della-Fera, Mary Anne, Baile, Clifton A.

“…Although leptin causes negative energy balance by reducing food intake and increasing energy expenditure, the effect of leptin on spontaneous physical activity…”
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Functional outcome measures in a surgical model of hip osteoarthritis in dogs by Little, Dianne, Johnson, Stephen, Hash, Jonathan, Olson, Steven A., Estes, Bradley T., Moutos, Franklin T., Lascelles, B. Duncan X., Guilak, Farshid

“…Background The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip…”
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Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum by Little, D, Brown, S.A, Campbell, N.B, Moeser, A.J, Davis, J.L, Blikslager, A.T

“…To determine the effect of meloxicam and flunixin meglumine on recovery of ischemia-injured equine jejunum. 18 horses. Horses received butorphanol tartrate;…”
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Who or what controls tendon? by Little, Dianne

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PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum by Little, Dianne, Dean, Rebecca A, Young, Karen M, McKane, Shaun A, Martin, Linda D, Jones, Samuel L, Blikslager, Anthony T

“…We have previously shown that PGE(2) and PGI(2) induce recovery of transepithelial resistance (TER) in ischemia-injured porcine ileal mucosa, associated with…”
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Letter From the Guest Editor by Little, Dianne

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Current Status of Tissue-engineered Scaffolds for Rotator Cuff Repair by Chainani, Abby, Little, Dianne

“…Rotator cuff tears continue to be at significant risk for retear or for failure to heal after surgical repair despite the use of a variety of surgical…”
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Is it ebola DOC? by Little, Dianne

“…A middle aged man had recently returned from the Republic of Congo where he had been working for several years. His vaccinations were up to date and he was…”
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Is it ebola DOC? by Little, Dianne

“…A middle aged man had recently returned from the Republic of Congo where he had been working for several years. His vaccinations were up to date and he was…”
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Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas‐Induced Apoptosis–Transgenic Mice by Wu, Chia‐Lung, McNeill, Jenna, Goon, Kelsey, Little, Dianne, Kimmerling, Kelly, Huebner, Janet, Kraus, Virginia, Guilak, Farshid

“…Objective To investigate whether short‐term, systemic depletion of macrophages can mitigate osteoarthritis (OA) following injury in the setting of obesity…”
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Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering by Orr, Steven B., Chainani, Abby, Hippensteel, Kirk J., Kishan, Alysha, Gilchrist, Christopher, Garrigues, N. William, Ruch, David S., Guilak, Farshid, Little, Dianne

“…[Display omitted] The rotator cuff consists of several tendons and muscles that provide stability and force transmission in the shoulder joint. Whereas most…”
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