Search Results - "LIRK, Philipp"

The Science of Local Anesthesia: Basic Research, Clinical Application, and Future Directions by Lirk, Philipp, Hollmann, Markus W., Strichartz, Gary

“…Local anesthetics have been used clinically for more than a century, but new insights into their mechanisms of action and their interaction with biological…”
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Perioperative Anesthesia Care and Tumor Progression by Sekandarzad, Mir W., van Zundert, André A.J., Lirk, Philipp B., Doornebal, Chris W., Hollmann, Markus W.

“…This narrative review discusses the most recent up-to-date findings focused on the currently available “best clinical practice” regarding perioperative…”
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The demographics of persistent opioid consumption following limb amputation by Steen, Talora, Lirk, Philipp B., Sigurdsson, Martin I.

“…Background Patients who have limb amputation are at risk of chronic pain, including phantom limb pain that can be challenging to treat. The aim of this study…”
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Risk of Major Complications After Perioperative Norepinephrine Infusion Through Peripheral Intravenous Lines in a Multicenter Study by Pancaro, Carlo, Shah, Nirav, Pasma, Wietze, Saager, Leif, Cassidy, Ruth, van Klei, Wilton, Kooij, Fabian, Vittali, Dave, Hollmann, Markus W., Kheterpal, Sachin, Lirk, Philipp

“…BACKGROUND:Continuous infusions of norepinephrine to treat perioperative hypotension are typically administered through a central venous line rather than a…”
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Local Anesthetic-Induced Neurotoxicity by Verlinde, Mark, Hollmann, Markus W, Stevens, Markus F, Hermanns, Henning, Werdehausen, Robert, Lirk, Philipp

“…This review summarizes current knowledge concerning incidence, risk factors, and mechanisms of perioperative nerve injury, with focus on local…”
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Long-term outcome in pediatric surgical bypass grafting after traumatic injury and tumor resection: retrospective cohort analysis by Kampf, Stephanie, Willegger, Madeleine, Dawoud, Christopher, Fülöp, Gerhard, Lirk, Philipp, Willfort-Ehringer, Andrea, Neumayer, Christoph, Gollackner, Bernd

“…Vascular bypass surgery in children differs significantly from adults. It is a rarely performed procedure in the setting of trauma and tumor surgery. Besides…”
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Inducible nitric oxide synthase (iNOS) in tumor biology: The two sides of the same coin by Lechner, Matthias, Lirk, Philipp, Rieder, Josef

“…Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid l-arginine. iNOS-derived NO plays an…”
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Pain management after laparoscopic hysterectomy: systematic review of literature and PROSPECT recommendations by Lirk, Philipp, Thiry, Juliette, Bonnet, Marie-Pierre, Joshi, Girish P, Bonnet, Francis, Beloeil, H, Hill, A, Kehlet, H, Lavand’homme, P, Pogatzki-Zahn, E, Rawal, N, Raeder, J, Schug, S, van de Velde, M

“…Background and objectivesLaparoscopic hysterectomy is increasingly performed because it is associated with less postoperative pain and earlier recovery as…”
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A radiological cadaveric study of obturator nerve involvement and cranial injectate spread after different approaches to the fascia iliaca compartment block by ten Hoope, Werner, Smulders, Pascal S. H., Baumann, Holger M., Hermanides, Jeroen, Beenen, Ludo F. M., Oostra, Roelof-Jan, Marhofer, Peter, Lirk, Philipp, Hollmann, Markus W.

“…Whether the fascia iliaca compartment block (FICB) involves the obturator nerve (ON) remains controversial. Involvement may require that the injectate spreads…”
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NMDA Receptor Antagonist Ketamine Distorts Object Recognition by Reducing Feedback to Early Visual Cortex by van Loon, Anouk M, Fahrenfort, Johannes J, van der Velde, Bauke, Lirk, Philipp B, Vulink, Nienke C C, Hollmann, Markus W, Scholte, H Steven, Lamme, Victor A F

“…It is a well-established fact that top-down processes influence neural representations in lower-level visual areas. Electrophysiological recordings in monkeys…”
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The Efficacy of Preemptive Analgesia for Acute Postoperative Pain Management: A Meta-Analysis by Ong, Cliff K.-S., Lirk, Philipp, Seymour, Robin A., Jenkins, Brian J.

“…Whether preemptive analgesic interventions are more effective than conventional regimens in managing acute postoperative pain remains controversial. We…”
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Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C‐type units after painful nerve injury by Gemes, Geza, Koopmeiners, Andrew, Rigaud, Marcel, Lirk, Philipp, Sapunar, Damir, Bangaru, Madhavi Latha, Vilceanu, Daniel, Garrison, Sheldon R., Ljubkovic, Marko, Mueller, Samantha J., Stucky, Cheryl L., Hogan, Quinn H.

“…Key points The peripheral terminals of sensory neurons encode physical and chemical signals into trains of action potentials (APs) and transmit these trains to…”
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Insights into postoperative respiration by using continuous wireless monitoring of respiratory rate on the postoperative ward: a cohort study by Posthuma, Linda M., Visscher, Maarten J., Lirk, Philipp B., van Dijkum, Els J. M. Nieveen, Hollmann, Markus W., Preckel, Benedikt

“…Change of respiratory rate (RespR) is the most powerful predictor of clinical deterioration. Brady- (RespR ≤ 8) and tachypnea (RespR ≥ 31) are associated with…”
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Ultrasound-guided supraclavicular vs. retroclavicular block of the brachial plexus: comparison of ipsilateral diaphragmatic function: A randomised clinical trial by Georgiadis, Paige L., Vlassakov, Kamen V., Patton, Megan E., Lirk, Philipp B., Janfaza, David R., Zeballos, Jose L., Quaye, Aurora N., Patel, Vijay, Schreiber, Kristin L.

“…BACKGROUNDThe ultrasound-guided retroclavicular block (RCB) is a recently described alternative approach to brachial plexus blockade at the level of the cords…”
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NMDA receptor antagonist ketamine impairs feature integration in visual perception by Meuwese, Julia D I, van Loon, Anouk M, Scholte, H Steven, Lirk, Philipp B, Vulink, Nienke C C, Hollmann, Markus W, Lamme, Victor A F

“…Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground…”
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Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy by ten Hoope, Werner, Hollmann, Markus W, de Bruin, Kora, Verberne, Hein J, Verkerk, Arie O, Tan, Hanno L, Verhamme, Camiel, Horn, Janneke, Rigaud, Marcel, Picardi, Susanne, Lirk, Philipp

“…BACKGROUND:Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic…”
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Paravertebral Blocks for Same-Day Breast Surgery by Jones, Mark R., Hadley, Graham R., Kaye, Alan D., Lirk, Philipp, Urman, Richard D.

“…Purpose of Review Breast surgery, performed for medical or cosmetic reasons, remains one of the most frequently performed procedures, with over 500,000 cases…”
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Influence on number of top-ups after implementing patient controlled epidural analgesia: A cohort study by van Samkar, Ganapathy, Hermanns, Henning, Lirk, Philipp, Hollmann, Markus W, Stevens, Markus F

“…Postoperative epidural analgesia often needs rate readjustment using top-ups. Patient-controlled epidural analgesia (PCEA) is said to reduce the requirement of…”
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In Vitro, Inhibition of Mitogen-Activated Protein Kinase Pathways Protects Against Bupivacaine- and Ropivacaine-Induced Neurotoxicity by Lirk, Philipp, Haller, Ingrid, Peter, Hans, Lang, Leopold, Tomaselli, Bettina, Klimaschewski, Lars, Gerner, Peter

“…Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this…”
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Emergency Department Pain Management in Adult Patients With Traumatic Injuries Before and After Implementation of a Nurse-Initiated Pain Treatment Protocol Utilizing Fentanyl for Severe Pain by Ridderikhof, Milan L., MD, Schyns, Frederick J., MD, Schep, Niels W., MD, PhD, Lirk, Philipp, MD, PhD, Hollmann, Markus W., MD, PhD, Goslings, J. Carel, MD, PhD

“…Abstract Background Pain management in the emergency department (ED) remains suboptimal. Nursing staff protocols could improve this, but studies show divergent…”
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