Search Results - "LIPKIN, Steven M"

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors by Dohlman, Anders B, Klug, Jared, Mesko, Marissa, Gao, Iris H, Lipkin, Steven M, Shen, Xiling, Iliev, Iliyan D

“…Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the human microbiome, yet little is known about their role in human cancers…”
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The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants by Dohlman, Anders B., Arguijo Mendoza, Diana, Ding, Shengli, Gao, Michael, Dressman, Holly, Iliev, Iliyan D., Lipkin, Steven M., Shen, Xiling

“…Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical…”
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Immune Activation in Mismatch Repair-Deficient Carcinogenesis: More Than Just Mutational Rate by Willis, Jason A, Reyes-Uribe, Laura, Chang, Kyle, Lipkin, Steven M, Vilar, Eduardo

“…Mismatch repair (MMR)-deficient colorectal cancers (dMMR colorectal cancer) are characterized by the expression of highly immunogenic neoantigen peptides,…”
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A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells by Bu, Pengcheng, Chen, Kai-Yuan, Chen, Joyce Huan, Wang, Lihua, Walters, Jewell, Shin, Yong Jun, Goerger, Julian P., Sun, Jian, Witherspoon, Mavee, Rakhilin, Nikolai, Li, Jiahe, Yang, Herman, Milsom, Jeff, Lee, Sang, Zipfel, Warren, Jin, Moonsoo M., Gümüş, Zeynep H., Lipkin, Steven M., Shen, Xiling

“…microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and oncogenesis in distinct ways relative to proteins. Here, we show that the tumor…”
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A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer by Bu, Pengcheng, Wang, Lihua, Chen, Kai-Yuan, Srinivasan, Tara, Murthy, Preetish Kadur Lakshminarasimha, Tung, Kuei-Ling, Varanko, Anastasia Kristine, Chen, Huanhuan Joyce, Ai, Yiwei, King, Sarah, Lipkin, Steven M., Shen, Xiling

“…Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other…”
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Cascading After Peridiagnostic Cancer Genetic Testing: An Alternative to Population-Based Screening by Offit, Kenneth, Tkachuk, Kaitlyn A, Stadler, Zsofia K, Walsh, Michael F, Diaz-Zabala, Hector, Levin, Jeffrey D, Steinsnyder, Zoe, Ravichandran, Vignesh, Sharaf, Ravi N, Frey, Melissa K, Lipkin, Steven M, Robson, Mark E, Hamilton, Jada G, Vijai, Joseph, Mukherjee, Semanti

“…Despite advances in DNA sequencing technology and expanded medical guidelines, the vast majority of individuals carrying pathogenic variants of common cancer…”
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A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division by Wang, Lihua, Bu, Pengcheng, Ai, Yiwei, Srinivasan, Tara, Chen, Huanhuan Joyce, Xiang, Kun, Lipkin, Steven M, Shen, Xiling

“…The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the…”
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NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer by SIKANDAR, Shaheen S, PATE, Kira T, ANDERSON, Scott, DIZON, Diana, EDWARDS, Robert A, WATERMAN, Marian L, LIPKIN, Steven M

“…NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for initiating colorectal adenomas and colorectal cancers (CRC). Based on…”
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Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies by Sei, Shizuko, Ahadova, Aysel, Keskin, Derin B, Bohaumilitzky, Lena, Gebert, Johannes, von Knebel Doeberitz, Magnus, Lipkin, Steven M, Kloor, Matthias

“…Hereditary cancer syndromes (HCS) account for 5~10% of all cancer diagnosis. Lynch syndrome (LS) is one of the most common HCS, caused by germline mutations in…”
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Effects of Socioeconomic Status and Treatment Disparities in Colorectal Cancer Survival by LE, Hoa, ZIOGAS, Argyrios, LIPKIN, Steven M, ZELL, Jason A

“…Background: Poor survival among colorectal cancer (CRC) cases has been associated with African-American race and low socioeconomic status (SES). However, it is…”
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Proteomic characterization of outer membrane vesicles from gut mucosa-derived fusobacterium nucleatum by Liu, Jinjing, Hsieh, Ching-Lin, Gelincik, Ozkan, Devolder, Bryan, Sei, Shizuko, Zhang, Sheng, Lipkin, Steven M., Chang, Yung-Fu

“…Fusobacterium nucleatum is a Gram-negative bacterium commonly found in the oral cavity and is often involved in periodontal diseases. Recent studies have shown…”
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NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells by Srinivasan, Tara, Walters, Jewell, Bu, Pengcheng, Than, Elaine Bich, Tung, Kuei-Ling, Chen, Kai-Yuan, Panarelli, Nicole, Milsom, Jeff, Augenlicht, Leonard, Lipkin, Steven M, Shen, Xiling

“…Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can…”
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Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice by Zhao, Fang, Edwards, Robert, Dizon, Diana, Afrasiabi, Kambiz, Mastroianni, Jennifer R., Geyfman, Mikhail, Ouellette, André J., Andersen, Bogi, Lipkin, Steven M

“…Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental…”
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miR-23a promotes the transition from indolent to invasive colorectal cancer by Jahid, Sohail, Sun, Jian, Edwards, Robert A, Dizon, Diana, Panarelli, Nicole C, Milsom, Jeffrey W, Sikandar, Shaheen S, Gümüs, Zeynep H, Lipkin, Steven M

“…Colorectal cancer is a classic example of a tumor that progresses through multiple distinct stages in its evolution. To understand the mechanisms regulating…”
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Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Association” Principle by Guo, Yu, Wei, Xiaomu, Das, Jishnu, Grimson, Andrew, Lipkin, Steven M., Clark, Andrew G., Yu, Haiyuan

“…To better understand different molecular mechanisms by which mutations lead to various human diseases, we classified 82,833 disease-associated mutations…”
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A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal by Chen, Kai‐Yuan, Srinivasan, Tara, Tung, Kuei‐Ling, Belmonte, Julio M, Wang, Lihua, Murthy, Preetish Kadur Lakshminarasimha, Choi, Jiahn, Rakhilin, Nikolai, King, Sarah, Varanko, Anastasia Kristine, Witherspoon, Mavee, Nishimura, Nozomi, Glazier, James A, Lipkin, Steven M, Bu, Pengcheng, Shen, Xiling

“…The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling stem cells. The number and identity of these dividing and…”
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Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk by Waller, Rosalie G, Darlington, Todd M, Wei, Xiaomu, Madsen, Michael J, Thomas, Alun, Curtin, Karen, Coon, Hilary, Rajamanickam, Venkatesh, Musinsky, Justin, Jayabalan, David, Atanackovic, Djordje, Rajkumar, S Vincent, Kumar, Shaji, Slager, Susan, Middha, Mridu, Galia, Perrine, Demangel, Delphine, Salama, Mohamed, Joseph, Vijai, McKay, James, Offit, Kenneth, Klein, Robert J, Lipkin, Steven M, Dumontet, Charles, Vachon, Celine M, Camp, Nicola J

“…The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in…”
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Have Cells Harboring the HIV Reservoir Been Immunoedited? by Huang, Szu-Han, McCann, Chase D, Mota, Talia M, Wang, Chao, Lipkin, Steven M, Jones, R Brad

“…Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination…”
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Race, Socioeconomic Status, Treatment, and Survival Time among Pancreatic Cancer Cases in California by ZELL, Jason A, RHEE, Jessica M, ZIOGAS, Argyrios, LIPKIN, Steven M, ANTON-CULVER, Hoda

“…Background: Poor survival in pancreatic adenocarcinoma is associated with African-American race and also with low socioeconomic status (SES). However, it is…”
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Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease―Associated Colorectal Cancer by EDWARDS, Robert A, WITHERSPOON, Mavee, KEHUI WANG, AFRASIABI, Kambiz, PHAM, Trang, BIRNBAUMER, Lutz, LIPKIN, Steven M

“…Sporadic human mismatch repair (MMR)-deficient colorectal cancers account for approximately 12.5% of all cases of colorectal cancer. MMR-deficient colorectal…”
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