Search Results - "LINZHAO CHENG"

Serum IgA, IgM, and IgG responses in COVID-19 by Ma, Huan, Zeng, Weihong, He, Hongliang, Zhao, Dan, Jiang, Dehua, Zhou, Peigen, Cheng, Linzhao, Li, Yajuan, Ma, Xiaoling, Jin, Tengchuan

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Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution by Li, Bin, Zhang, Wen, Guo, Chuang, Xu, Hao, Li, Longfei, Fang, Minghao, Hu, Yinlei, Zhang, Xinye, Yao, Xinfeng, Tang, Meifang, Liu, Ke, Zhao, Xuetong, Lin, Jun, Cheng, Linzhao, Chen, Falai, Xue, Tian, Qu, Kun

“…Spatial transcriptomics approaches have substantially advanced our capacity to detect the spatial distribution of RNA transcripts in tissues, yet it remains…”
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Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease by Zou, Jizhong, Mali, Prashant, Huang, Xiaosong, Dowey, Sarah N., Cheng, Linzhao

“…Human induced pluripotent stem cells (iPSCs) bearing monogenic mutations have great potential for modeling disease phenotypes, screening candidate drugs, and…”
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Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells by Liu, Senquan, Mahairaki, Vasiliki, Bai, Hao, Ding, Zheng, Li, Jiaxin, Witwer, Kenneth W., Cheng, Linzhao

“…Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communications and exert various biological activities via delivering…”
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Production of Gene‐Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation by Huang, Xiaosong, Wang, Ying, Yan, Wei, Smith, Cory, Ye, Zhaohui, Wang, Jing, Gao, Yongxing, Mendelsohn, Laurel, Cheng, Linzhao

“…Human induced pluripotent stem cells (iPSCs) and genome editing provide a precise way to generate gene‐corrected cells for disease modeling and cell therapies…”
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Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs by Smith, Cory, Gore, Athurva, Yan, Wei, Abalde-Atristain, Leire, Li, Zhe, He, Chaoxia, Wang, Ying, Brodsky, Robert A., Zhang, Kun, Cheng, Linzhao, Ye, Zhaohui

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Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix by Kusuma, Sravanti, Shen, Yu-I, Hanjaya-Putra, Donny, Mali, Prashant, Cheng, Linzhao, Gerecht, Sharon

“…The success of tissue regenerative therapies is contingent on functional and multicellular vasculature within the redeveloping tissue. Although endothelial…”
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Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior by Linville, Raleigh M., DeStefano, Jackson G., Sklar, Matt B., Xu, Zinnia, Farrell, Alanna M., Bogorad, Max I., Chu, Chengyan, Walczak, Piotr, Cheng, Linzhao, Mahairaki, Vasiliki, Whartenby, Katharine A., Calabresi, Peter A., Searson, Peter C.

“…Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major…”
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Synaptic dysregulation in a human iPS cell model of mental disorders by Wen, Zhexing, Nguyen, Ha Nam, Guo, Ziyuan, Lalli, Matthew A., Wang, Xinyuan, Su, Yijing, Kim, Nam-Shik, Yoon, Ki-Jun, Shin, Jaehoon, Zhang, Ce, Makri, Georgia, Nauen, David, Yu, Huimei, Guzman, Elmer, Chiang, Cheng-Hsuan, Yoritomo, Nadine, Kaibuchi, Kozo, Zou, Jizhong, Christian, Kimberly M., Cheng, Linzhao, Ross, Christopher A., Margolis, Russell L., Chen, Gong, Kosik, Kenneth S., Song, Hongjun, Ming, Guo-li

“…Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology…”
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Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions by Swistowski, Andrzej, Peng, Jun, Liu, Qiuyue, Mali, Prashant, Rao, Mahendra S., Cheng, Linzhao, Zeng, Xianmin

“…Human induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells represent a promising unlimited cell source for generating patient‐specific cells…”
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Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures by Chou, Bin-Kuan, Mali, Prashant, Huang, Xiaosong, Ye, Zhaohui, Dowey, Sarah N, Resar, Linda MS, Zou, Chunlin, Zhang, Y Alex, Tong, Jay, Cheng, Linzhao

“…To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells （iPSCs）, we investigated epigenetic and gene…”
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Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression by Dowey, Sarah N, Huang, Xiaosong, Chou, Bin-Kuan, Ye, Zhaohui, Cheng, Linzhao

“…Several human postnatal somatic cell types have been successfully reprogrammed to induced pluripotent stem cells (iPSCs). Blood mononuclear cells (MNCs) offer…”
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Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease–mediated safe harbor targeting by Zou, Jizhong, Sweeney, Colin L., Chou, Bin-Kuan, Choi, Uimook, Pan, Jason, Wang, Hongmei, Dowey, Sarah N., Cheng, Linzhao, Malech, Harry L.

“…We have developed induced pluripotent stem cells (iPSCs) from a patient with X-linked chronic granulomatous disease (X-CGD), a defect of neutrophil…”
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Concise Review: Human Cell Engineering: Cellular Reprogramming and Genome Editing by Mali, Prashant, Cheng, Linzhao

“…Cell engineering is defined here as the collective ability to both reset and edit the genome of a mammalian cell. Until recently, this had been extremely…”
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Efficient and Scalable Expansion of Human Pluripotent Stem Cells Under Clinically Compliant Settings: A View in 2013 by Wang, Ying, Cheng, Linzhao, Gerecht, Sharon

“…Human pluripotent stem cells (hPSCs) hold great promise for revolutionizing regenerative medicine for their potential applications in disease modeling, drug…”
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Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts by Mali, Prashant, Ye, Zhaohui, Hommond, Holly H., Yu, Xiaobing, Lin, Jeff, Chen, Guibin, Zou, Jizhong, Cheng, Linzhao

“…It was reported recently that human fibroblasts can be reprogrammed into a pluripotent state that resembles that of human embryonic stem (hES) cells. This was…”
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Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors by Choi, In Young, Lim, Hotae, Cho, Hyeon Jin, Oh, Yohan, Chou, Bin-Kuan, Bai, Hao, Cheng, Linzhao, Kim, Yong Jun, Hyun, SangHwan, Kim, Hyesoo, Shin, Joo Heon, Lee, Gabsang

“…Generation of skeletal muscle cells with human pluripotent stem cells (hPSCs) opens new avenues for deciphering essential, but poorly understood aspects of…”
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Concise Review: Stem Cell‐Based Approaches to Red Blood Cell Production for Transfusion by Shah, Siddharth, Huang, Xiaosong, Cheng, Linzhao

“…Blood transfusion is a common procedure in modern medicine, and it is practiced throughout the world; however, many countries report a less than sufficient…”
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Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes by Mali, Prashant, Chou, Bin‐Kuan, Yen, Jonathan, Ye, Zhaohui, Zou, Jizhong, Dowey, Sarah, Brodsky, Robert A., Ohm, Joyce E., Yu, Wayne, Baylin, Stephen B., Yusa, Kosuke, Bradley, Allan, Meyers, David J., Mukherjee, Chandrani, Cole, Philip A., Cheng, Linzhao

“…We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the…”
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Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells by Zou, Jizhong, Maeder, Morgan L., Mali, Prashant, Pruett-Miller, Shondra M., Thibodeau-Beganny, Stacey, Chou, Bin-Kuan, Chen, Guibin, Ye, Zhaohui, Park, In-Hyun, Daley, George Q., Porteus, Matthew H., Joung, J. Keith, Cheng, Linzhao

“…We report here homologous recombination (HR)-mediated gene targeting of two different genes in human iPS cells (hiPSCs) and human ES cells (hESCs). HR-mediated…”
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