Search Results - "LINTON, Macrae F"

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis by Linton, MacRae F, Moslehi, Javid J, Babaev, Vladimir R

“…The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis…”
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Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis by Linton, MacRae F., Babaev, Vladimir R., Huang, Jiansheng, Linton, Edward F., Tao, Huan, Yancey, Patricia G.

“…Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process called efferocytosis, are crucial determinants of atherosclerosis lesion…”
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SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis by Linton, MacRae F, Tao, Huan, Linton, Edward F, Yancey, Patricia G

“…The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic…”
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HDL Function and Atherosclerosis: Reactive Dicarbonyls as Promising Targets of Therapy by Linton, MacRae F, Yancey, Patricia G, Tao, Huan, Davies, Sean S

“…Epidemiologic studies detected an inverse relationship between HDL (high-density lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular…”
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Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor-Dependent and -Independent Mechanisms by RASHID, Shirya, TAVORI, Hagai, BROWN, Patrick E, LINTON, MacRae F, JANE HE, GIUNZIONI, Ilaria, FAZIO, Sergio

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in…”
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Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages by Mueller, Paul A, Zhu, Lin, Tavori, Hagai, Huynh, Katherine, Giunzioni, Ilaria, Stafford, John M, Linton, MacRae F, Fazio, Sergio

“…BACKGROUND:We previously showed that mice lacking MΦLRP1 (low-density lipoprotein receptor–related protein 1 in macrophages) undergo accelerated…”
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Local effects of human PCSK9 on the atherosclerotic lesion by Giunzioni, Ilaria, Tavori, Hagai, Covarrubias, Roman, Major, Amy S, Ding, Lei, Zhang, Youmin, DeVay, Rachel M, Hong, Liang, Fan, Daping, Predazzi, Irene M, Rashid, Shirya, Linton, MacRae F, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes atherosclerosis by increasing low‐density lipoprotein (LDL) cholesterol levels through…”
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Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis by Yamamoto, Suguru, MD, PhD, Yancey, Patricia G., PhD, Ikizler, T. Alp, MD, Jerome, W. Gray, PhD, Kaseda, Ryohei, MD, PhD, Cox, Brian, PhD, Bian, Aihua, MPH, Shintani, Ayumi, PhD, MPH, Fogo, Agnes B., MD, Linton, MacRae F., MD, Fazio, Sergio, MD, PhD, Kon, Valentina, MD

“…Objectives This study examined the functionality of high-density lipoprotein (HDL) in individuals with end-stage renal disease on dialysis (ESRD-HD)…”
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Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms by Tavori, Hagai, Giunzioni, Ilaria, Predazzi, Irene M, Plubell, Deanna, Shivinsky, Anna, Miles, Joshua, Devay, Rachel M, Liang, Hong, Rashid, Shirya, Linton, MacRae F, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of hepatic low-density lipoprotein (LDL) receptors (LDLR), thereby, decreasing…”
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Loss of Plasma Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) After Lipoprotein Apheresis by Tavori, Hagai, Giunzioni, Ilaria, Linton, MacRae F, Fazio, Sergio

“…RATIONALE:Lipoprotein apheresis (LA) reduces low-density lipoprotein (LDL) levels in patients with severe familial hypercholesterolemia (FH). We have recently…”
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Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis[S] by Tao, Huan, Yancey, Patricia G., Babaev, Vladimir R., Blakemore, John L., Zhang, Youmin, Ding, Lei, Fazio, Sergio, Linton, MacRae F.

“…Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE-…”
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Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia by Beigneux, Anne P, Miyashita, Kazuya, Ploug, Michael, Blom, Dirk J, Ai, Masumi, Linton, MacRae F, Khovidhunkit, Weerapan, Dufour, Robert, Garg, Abhimanyu, McMahon, Maureen A, Pullinger, Clive R, Sandoval, Norma P, Hu, Xuchen, Allan, Christopher M, Larsson, Mikael, Machida, Tetsuo, Murakami, Masami, Reue, Karen, Tontonoz, Peter, Goldberg, Ira J, Moulin, Philippe, Charrière, Sybil, Fong, Loren G, Nakajima, Katsuyuki, Young, Stephen G

“…Six patients with severe hypertriglyceridemia (chylomicronemia) were found to have autoantibodies against a capillary endothelial-cell protein (GPIHBP1) that…”
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Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr−/− mice by Tao, Huan, Huang, Jiansheng, Yancey, Patricia G., Yermalitsky, Valery, Blakemore, John L., Zhang, Youmin, Ding, Lei, Zagol-Ikapitte, Irene, Ye, Fei, Amarnath, Venkataraman, Boutaud, Olivier, Oates, John A., Roberts, L. Jackson, Davies, Sean S., Linton, MacRae F.

“…Lipid peroxidation generates reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins. Humans with…”
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Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis by Erbay, Ebru, Snitow, Melinda E, Hotamisligil, Gökhan S, Charles, Khanichi N, Fazio, Sergio, Makowski, Liza, Linton, MacRae F, Wiest, Michelle M, Watkins, Steven M, Mayers, Jared R, Babaev, Vladimir R

“…Gökhan Hotamisligil and his colleagues report that reducing endoplasmic reticulum stress in macrophages by targeting the lipid chaperone aP2 ameliorates…”
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Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry by Jiang, Lan, Gangireddy, Srushti, Dickson, Alyson L., Xin, Yi, Yan, Chao, Kawai, Vivian, Cox, Nancy J., Linton, MacRae F., Wei, Wei-Qi, Stein, C. Michael, Feng, QiPing

“…Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic…”
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The FoxOs are in the ApoM house by Linton, MacRae F, Yancey, Patricia G, Leuthner, Zoe M, Brown, Jonathan D

“…The prevalence of metabolic syndrome continues to increase globally and heightens the risk for cardiovascular disease (CVD). Insulin resistance is a core…”
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Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease by Lewis, Terry L., Cao, Dongfeng, Lu, Hailin, Mans, Robert A., Su, Yan Ru, Jungbauer, Lisa, Linton, MacRae F., Fazio, Sergio, LaDu, Mary Jo, Li, Ling

“…To date there is no effective therapy for Alzheimer disease (AD). High levels of circulating high density lipoprotein (HDL) and its main protein,…”
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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 by Makowski, Liza, Hotamisligil, Gökhan S, Tuncman, Gürol, Görgün, Cem Z, Fazio, Sergio, Parker, Rex A, Kono, Keita, Robl, Jeffrey A, Atsumi, Genichi, Sulsky, Richard, Babaev, Vladimir R, Furuhashi, Masato, Linton, MacRae F, Vaillancourt, Eric

“…Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in…”
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LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8 by Allen, Ryan M., Michell, Danielle L., Cavnar, Ashley B., Zhu, Wanying, Makhijani, Neil, Contreras, Danielle M., Raby, Chase A., Semler, Elizabeth M., DeJulius, Carlisle, Castleberry, Mark, Zhang, Youmin, Ramirez-Solano, Marisol, Zhao, Shilin, Duvall, Craig, Doran, Amanda C., Sheng, Quanhu, Linton, MacRae F., Vickers, Kasey C.

“…Macrophages present a spectrum of phenotypes that mediate both the pathogenesis and resolution of atherosclerotic lesions. Inflammatory macrophage phenotypes…”
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Inhibition of Toll-like Receptors Alters Macrophage Cholesterol Efflux and Foam Cell Formation by Kim, Jaemi, Kim, Ji-Yun, Byeon, Hye-Eun, Kim, Ji-Won, Kim, Hyoun-Ah, Suh, Chang-Hee, Choi, Sangdun, Linton, MacRae F, Jung, Ju-Yang

“…Arterial macrophage cholesterol accumulation and impaired cholesterol efflux lead to foam cell formation and the development of atherosclerosis. Modified…”
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