Search Results - "LINSLEY, Peter S"

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application by Jackson, Aimee L, Linsley, Peter S

“…Key Points Small interfering RNAs (siRNAs) are widely used to study gene function and there is general excitement about their potential for therapeutic…”
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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data by Finak, Greg, McDavid, Andrew, Yajima, Masanao, Deng, Jingyuan, Gersuk, Vivian, Shalek, Alex K, Slichter, Chloe K, Miller, Hannah W, McElrath, M Juliana, Prlic, Martin, Linsley, Peter S, Gottardo, Raphael

“…Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in…”
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Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis by Linsley, Peter S, Speake, Cate, Whalen, Elizabeth, Chaussabel, Damien

“…While immunotherapies are rapidly becoming mainstays of cancer treatment, significant gaps remain in our understanding of how to optimally target them, alone…”
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Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy by Sheih, Alyssa, Voillet, Valentin, Hanafi, Laïla-Aïcha, DeBerg, Hannah A., Yajima, Masanao, Hawkins, Reed, Gersuk, Vivian, Riddell, Stanley R., Maloney, David G., Wohlfahrt, Martin E., Pande, Dnyanada, Enstrom, Mark R., Kiem, Hans-Peter, Adair, Jennifer E., Gottardo, Raphaël, Linsley, Peter S., Turtle, Cameron J.

“…Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and…”
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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice by Boldin, Mark P, Taganov, Konstantin D, Rao, Dinesh S, Yang, Lili, Zhao, Jimmy L, Kalwani, Manorama, Garcia-Flores, Yvette, Luong, Mui, Devrekanli, Asli, Xu, Jessica, Sun, Guizhen, Tay, Jia, Linsley, Peter S, Baltimore, David

“…Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly…”
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators by Gabriely, Galina, Wurdinger, Thomas, Kesari, Santosh, Esau, Christine C., Burchard, Julja, Linsley, Peter S., Krichevsky, Anna M.

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MicroRNAs and Cell Cycle Regulation by Carleton, Michael, Cleary, Michele A., Linsley, Peter S.

“…MicroRNAs (microRNAs) are abundant, ~21-25 nucleotide (nt) non-coding RNAs that mediate sequence-specific, post-transcriptional repression of mRNA targets…”
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clinical utility of inhibiting CD28-mediated costimulation by Linsley, Peter S, Nadler, Steven G

“…This volume covers many topics in the field of T-cell costimulation. The need for such a volume is testament to the growth of the field. From its beginning as…”
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Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas by Linsley, Peter S., Nakayama, Maki, Balmas, Elisa, Chen, Janice, Barahmand-pour-Whitman, Fariba, Bansal, Shubham, Bottorff, Ty, Serti, Elisavet, Speake, Cate, Pugliese, Alberto, Cerosaletti, Karen

“…Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet…”
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Functional genomics identifies therapeutic targets for MYC-driven cancer by Toyoshima, Masafumi, Howie, Heather L, Imakura, Maki, Walsh, Ryan M, Annis, James E, Chang, Aaron N, Frazier, Jason, Chau, B. Nelson, Loboda, Andrey, Linsley, Peter S, Cleary, Michele A, Park, Julie R, Grandori, Carla

“…MYC oncogene family members are broadly implicated in human cancers, yet are considered “undruggable” as they encode transcription factors. MYC also carries…”
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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity by Jackson, Aimee L, Burchard, Julja, Schelter, Janell, Chau, B Nelson, Cleary, Michele, Lim, Lee, Linsley, Peter S

“…Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited complementarity to the active strand of the RNA duplex. This process…”
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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing by Jackson, Aimee L, Burchard, Julja, Leake, Devin, Reynolds, Angela, Schelter, Janell, Guo, Jie, Johnson, Jason M, Lim, Lee, Karpilow, Jon, Nichols, Kim, Marshall, William, Khvorova, Anastasia, Linsley, Peter S

“…Transfected siRNAs regulate numerous transcripts sharing limited complementarity to the RNA duplex. This unintended ("off-target") silencing can hinder the use…”
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The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types by Linsley, Peter S, Chaussabel, Damien, Speake, Cate

“…Enhancing pre-existing anti-tumor immunity leads to therapeutic benefit for some patients, but why some tumors are more immunogenic than others remains…”
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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression by Ivanovska, Irena, Ball, Alexey S., Diaz, Robert L., Magnus, Jill F., Kibukawa, Miho, Schelter, Janell M., Kobayashi, Sumire V., Lim, Lee, Burchard, Julja, Jackson, Aimee L., Linsley, Peter S., Cleary, Michele A.

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms by Parry, Richard V., Chemnitz, Jens M., Frauwirth, Kenneth A., Lanfranco, Anthony R., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Riley, James L.

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Comparison of different miR-21 inhibitor chemistries in a cardiac disease model by Thum, Thomas, Chau, Nelson, Bhat, Balkrishen, Gupta, Shashi Kumar, Linsley, Peter S, Bauersachs, Johann, Engelhardt, Stefan

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Noise amidst the silence: off-target effects of siRNAs? by Jackson, Aimee L., Linsley, Peter S.

“…RNA interference (RNAi), mediated by short interfering RNAs (siRNAs), is widely used to silence gene expression and to define gene function in mammalian cells…”
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Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215 by Georges, Sara A, Biery, Matthew C, Kim, Soo-Yeon, Schelter, Janell M, Guo, Jane, Chang, Aaron N, Jackson, Aimee L, Carleton, Michael O, Linsley, Peter S, Cleary, Michele A, Chau, B Nelson

“…Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in…”
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PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses by Anderson, Warren, Barahmand-Pour-Whitman, Fariba, Linsley, Peter S, Cerosaletti, Karen, Buckner, Jane H, Rawlings, David J

“…A genetic variant in the gene (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR…”
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Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression by Linsley, Peter S., Schelter, Janell, Burchard, Julja, Kibukawa, Miho, Martin, Melissa M., Bartz, Steven R., Johnson, Jason M., Cummins, Jordan M., Raymond, Christopher K., Dai, Hongyue, Chau, Nelson, Cleary, Michele, Jackson, Aimee L., Carleton, Michael, Lim, Lee

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