Search Results - "LINEBERGER, Janet"

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors by Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E

“…Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other…”
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Coupling of Human Immunodeficiency Virus Type 1 Fusion to Virion Maturation: a Novel Role of the gp41 Cytoplasmic Tail by WYMA, Donald J, JIYANG JIANG, JIONG SHI, JING ZHOU, LINEBERGER, Janet E, MILLER, Michael D, AIKEN, Christopher

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Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) by Stachel, Shawn J, Coburn, Craig A, Steele, Thomas G, Jones, Kristen G, Loutzenhiser, Elizabeth F, Gregro, Alison R, Rajapakse, Hemaka A, Lai, Ming-Tain, Crouthamel, Ming-Chih, Xu, Min, Tugusheva, Katherine, Lineberger, Janet E, Pietrak, Beth L, Espeseth, Amy S, Shi, Xiao-Ping, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Munshi, Sanjeev, Simon, Adam J, Kuo, Lawrence, Vacca, Joseph P

“…We describe the development of cell-permeable β-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an…”
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Nef Does Not Affect the Efficiency of Human Immunodeficiency Virus Type 1 Fusion with Target Cells by Tobiume, Minoru, Lineberger, Janet E, Lundquist, Christopher A, Miller, Michael D, Aiken, Christopher

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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties by Kim, Dooseop, Wang, Liping, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard J., MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Hrin, Renee C., Carver, Gwen, Carella, Anthony, Henry, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.

“…[Display omitted] A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the…”
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Biochemical and cell-based assays for characterization of BACE-1 inhibitors by Pietrak, Beth L., Crouthamel, Ming-Chih, Tugusheva, Katherine, Lineberger, Janet E., Xu, Min, DiMuzio, Jillian M., Steele, Thomas, Espeseth, Amy S., Stachel, Shawn J., Coburn, Craig A., Graham, Samuel L., Vacca, Joseph P., Shi, Xiao-Ping, Simon, Adam J., Hazuda, Daria J., Lai, Ming-Tain

“…The deposition of β-amyloid peptides (Aβ42 and Aβ40) in neuritic plaques is one of the hallmarks of Alzheimer’s disease (AD). Aβ peptides are derived from…”
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Altering Expression Levels of Human Immunodeficiency Virus Type 1 gp120-gp41 Affects Efficiency but Not Kinetics of Cell-Cell Fusion by Lineberger, Janet E, Danzeisen, Renee, Hazuda, Daria J, Simon, Adam J, Miller, Michael D

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes by Finke, Paul E., Oates, Bryan, Mills, Sander G., MacCoss, Malcolm, Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Schleif, William A., Emini, Emilio A.

“…(2 S)-2-(3-Chlorophenyl)-1-[ N-(methyl)- N-(phenylsulfonyl)amino]-4-[spiro(2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide ( 1b) has been…”
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Compounds That Bind APP and Inhibit Aβ Processing in Vitro Suggest a Novel Approach to Alzheimer Disease Therapeutics by Espeseth, Amy S., Xu, Min, Huang, Qian, Coburn, Craig A., Jones, Kristen L.G., Ferrer, Marc, Zuck, Paul D., Strulovici, Berta, Price, Eric A., Wu, Guoxin, Wolfe, Abigail L., Lineberger, Janet E., Sardana, Mohinder, Tugusheva, Katherine, Pietrak, Beth L., Crouthamel, Ming-Chih, Lai, Ming-Tain, Dodson, Elizabeth Chen, Bazzo, Renzo, Shi, Xiao-Ping, Simon, Adam J., Li, Yueming, Hazuda, Daria J.

“…Extracellular deposits of aggregated amyloid-β (Aβ) peptides are a hallmark of Alzheimer disease; thus, inhibition of Aβ production and/or aggregation is an…”
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and sar study of 4-pyrazolylpiperidine side chains by SHEN, Dong-Ming, MIN SHU, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, MILLS, Sander G, CHAPMAN, Kevin T, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L, DEMARTINO, Julie A, SICILIANO, Salvatore J, KWEI, Gloria Y

“…Replacement of the flexible connecting chains between the piperidine moiety and an aromatic group in previous CCR5 antagonists with heterocycles, such as…”
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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection by Kim, Dooseop, Wang, Liping, Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Carver, Gwen, Carella, Anthony, Holmes, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.

“…A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological…”
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CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells by Singer, I I, Scott, S, Kawka, D W, Chin, J, Daugherty, B L, DeMartino, J A, DiSalvo, J, Gould, S L, Lineberger, J E, Malkowitz, L, Miller, M D, Mitnaul, L, Siciliano, S J, Staruch, M J, Williams, H R, Zweerink, H J, Springer, M S

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A Critical Site in the Core of the CCR5 Chemokine Receptor Required for Binding and Infectivity of Human Immunodeficiency Virus Type 1 by Siciliano, Salvatore J., Kuhmann, Shawn E., Weng, Youmin, Madani, Navid, Springer, Martin S., Lineberger, Janet E., Danzeisen, Renee, Miller, Michael D., Kavanaugh, Michael P., DeMartino, Julie A., Kabat, David

“…Like the CCR5 chemokine receptors of humans and rhesus macaques, the very homologous (∼98–99% identical) CCR5 of African green monkeys (AGMs) avidly binds…”
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Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents by Chiu, Chi-Sung, Peekhaus, Norbert, Weber, Hans, Adamski, Sharon, Murray, Edward M, Zhang, Hai Zhuan, Zhao, Jing Zhang, Ernst, Robin, Lineberger, Janet, Huang, Lingyi, Hampton, Richard, Arnold, Beth Anne, Vitelli, Salvatore, Hamuro, Lora, Wang, Wei-Rong, Wei, Nan, Dillon, Greg M, Miao, Jiangyong, Alves, Stephen E, Glantschnig, Helmut, Wang, Fubao, Wilkinson, Hilary A

“…Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A…”
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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates by Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J

“…beta-Site amyloid precursor protein (APP)-cleaving enzyme (BACE) 1 cleavage of amyloid precursor protein is an essential step in the generation of the…”
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Macrocyclic Inhibitors of β-Secretase:  Functional Activity in an Animal Model by Stachel, Shawn J, Coburn, Craig A, Sankaranarayanan, Sethu, Price, Eric A, Pietrak, Beth L, Huang, Qian, Lineberger, Janet, Espeseth, Amy S, Jin, Lixia, Ellis, Joan, Holloway, M. Katharine, Munshi, Sanjeev, Allison, Timothy, Hazuda, Daria, Simon, Adam J, Graham, Samuel L, Vacca, Joseph P

“…A macrocyclic inhibitor of β-secretase was designed by covalently cross-linking the P1 and P3 side chains of an isophthalamide-based inhibitor…”
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BACE-1 inhibition by a series of ψ[CH 2NH] reduced amide isosteres by Coburn, Craig A., Stachel, Shawn J., Jones, Kristen G., Steele, Thomas G., Rush, Diane M., DiMuzio, Jillian, Pietrak, Beth L., Lai, Ming-Tain, Huang, Qian, Lineberger, Janet, Jin, Lixia, Munshi, Sanjeev, Katharine Holloway, M., Espeseth, Amy, Simon, Adam, Hazuda, Daria, Graham, Samuel L., Vacca, Joseph P.

“…A new class of β-secretase inhibitors that incorporate a reduced amide transition state isostere as the key binding element is described. The incorporation of…”
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes by DORN, Conrad P, FINKE, Paul E, DEMARTINO, Julie A, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, OATES, Bryan, SCHLEIF, William A, EMINI, Emilio A, BUDHU, Richard J, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L

“…Screening of the Merck sample collection for compounds with CCR5 receptor binding afforded…”
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains by Lynch, Christopher L., Willoughby, Christopher A., Hale, Jeffrey J., Holson, Edward J., Budhu, Richard J., Gentry, Amy L., Rosauer, Keith G., Caldwell, Charles G., Chen, Ping, Mills, Sander G., MacCoss, Malcolm, Berk, Scott, Chen, Liya, Chapman, Kevin T., Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Siciliano, Salvatore J., Cascieri, Margaret A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A., Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio A.

“…The 4-(3-phenylprop-1-yl)piperidine moiety of the 1,3,4-trisubstituted pyrrolidine CCR5 antagonist 1 was modified with electron deficient aromatics as well as…”
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Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells by Shi, Xiao-Ping, Tugusheva, Katherine, Bruce, James E, Lucka, Adam, Chen-Dodson, Elizabeth, Hu, Binghua, Wu, Guo-Xin, Price, Eric, Register, Robert B, Lineberger, Janet, Miller, Ron, Tang, Mei-Jy, Espeseth, Amy, Kahana, Jason, Wolfe, Abigail, Crouthamel, Ming-Chih, Sankaranarayanan, Sethu, Simon, Adam, Chen, Lin, Lai, Ming-Tain, Pietrak, Beth, DiMuzio, Jillian, Li, Yueming, Xu, Min, Huang, Qian, Garsky, Victor, Sardana, Mohinder K, Hazuda, Daria J

“…Abnormal production and accumulation of amyloid-beta peptide (Abeta) plays a major role in the pathogenesis of Alzheimer's disease (AD). beta-secretase (BACE1)…”
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