Search Results - "LINDSTROM, T. D"

High-precision dosimetry for radiotherapy using the optically stimulated luminescence technique and thin Al2O3:C dosimeters by Yukihara, E G, Yoshimura, E M, Lindstrom, T D, Ahmad, S, Taylor, K K, Mardirossian, G

“…The potential of using the optically stimulated luminescence (OSL) technique with aluminium oxide (Al(2)O(3):C) dosimeters for a precise and accurate…”
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Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers by LINDSTROM, T. D, HANSSEN, B. R, WRIGHTON, S. A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In Vitro Biotransformation and Identification of Human Cytochrome P450 Isozyme-Dependent Metabolism of Tazofelone by SURAPANENI, S. S, CLAY, M. P, SPANGLE, L. A, PASCHAL, J. W, LINDSTROM, T. D

“…Tazofelone is a new inflammatory bowel disease agent. The biotransformation of tazofelone in human livers and the cytochrome P450 responsible for the…”
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Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication by Stratford, Jr, R E, Clay, M P, Heinz, B A, Kuhfeld, M T, Osborne, S J, Phillips, D L, Sweetana, S A, Tebbe, M J, Vasudevan, V, Zornes, L L, Lindstrom, T D

“…Previous studies in rats and humans demonstrated poor oral bioavailability of potent in vitro 2-aminobenzimidazole inhibitors of rhinovirus replication due to…”
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Fused bicyclic Gly-asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere by FISHER, M. J, GIESE, U, RAPP, A, RÜHTER, G, RUTERBORIES, K. J, SALL, D. J, SCARBOROUGH, R. M, SCHOTTEN, T, STENZEL, W, TOWNER, R. D, UM, S. L, UTTERBACK, B. G, HARMS, C. S, WYSS, V. L, JAKUBOWSKI, J. A, KINNICK, M. D, LINDSTROM, T. D, MCCOWAN, J. R, MEST, H.-J, MORIN, J. M, MULLANEY, J. T, PAAL, M

“…6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement…”
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Disposition and biotransformation of quinpirole, a new D-2 dopamine agonist antihypertensive agent, in mice, rats, dogs, and monkeys by Whitaker, N G, Lindstrom, T D

“…The disposition and metabolism of quinpirole were studied in rats, mice, dogs, and monkeys. A single 2 mg/kg dose of 14C-quinpirole was administered orally to…”
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Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis by Bendele, A M, Benslay, D N, Hom, J T, Spaethe, S M, Ruterbories, K J, Lindstrom, T D, Lee, S J, Naismith, R W

“…Biofor 389 (BF389), dihydro-4-[[3,5-bis(1,1-dimethyl)-4-hydroxyphenyl] methylene]-2-methyl-2H-1,2-oxazin-3(4H)-one, was tested for anti-inflammatory activity…”
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Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys by Ruterbories, K J, Lindstrom, T D

“…Mice, rats, dogs, and monkeys were given a single 50 mg/kg oral dose of [14C]LY256548. Plasma levels of radioactivity and LY256548 were determined, as was the…”
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Chemoimmunoconjugate development for ovarian carcinoma therapy: Preclinical studies with vinca alkaloid-monoclonal antibody constructs by Apelgren, L. D, Bailey, D. L, Briggs, S. L, Barton, R. L, Guttman-Carlisle, D, Koppel, G. A, Nichols, C. L, Scott, W. L, Lindstrom, T. D

“…Preclinical efficacy studies are presented in a human ovarian carcinoma model utilizing several novel conjugation strategies with the KS1/4 monoclonal antibody…”
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Studies on cytochrome P-450-dependent lipid hydroperoxide reduction by Lindstrom, T D, Aust, S D

“…A reconstituted mixed-function oxidase system containing cytochrome P-450, cytochrome P-450 reductase, phosphatidylcholine, and NADPH catalyzed the reduction…”
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Effects of hepatic ischemia-reperfusion injury on the hepatic mixed function oxidase system in rats by Lindstrom, T D, Hanssen, B R, Bendele, A M

“…Hepatic ischemia induced in vivo by ligation of the left hepatic lobe of rats for up to 2 hr had no effect on cytochrome P-450, cytochrome c reductase, or lobe…”
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Pharmacokinetics and disposition of the KS1/4 monoclonal antibody-desacetylvinblastine hydrazide conjugate LY203725 in rats and monkeys by Lindstrom, T D, Althaus, W A, Ruterbories, K J, Kau, D

“…The plasma pharmacokinetics of the monoclonal antibody-vinca conjugate KS 1/4-desacetylvinblastine hydrazide (DAVLB-hyd; [3H]LY203725) have been evaluated in…”
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Correlation of anti-inflammatory activity with peak tissue rather than peak plasma levels of BF389 by Bendele, A M, Ruterbories, K J, Spaethe, S M, Benslay, D N, Lindstrom, T D, Lee, S J, Naismith, R W

“…BF389 (Biofor 389) is a potent anti-inflammatory agent in various animal models including adjuvant and type II collagen arthritis in rats. In vitro assays…”
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Disposition and metabolism of a new benzothiophene antiestrogen in rats, dogs and monkeys by Lindstrom, T D, Whitaker, N G, Whitaker, G W

“…A new benzothiophene-derived antiestrogen (LY156758) when orally administered was well absorbed in rats and monkeys while approx. 20% was absorbed in dogs. In…”
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Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection by Yu, Melvin J, McCowan, Jefferson R, Phebus, Lee A, Towner, Richard D, Ho, Peter P. K, Keith, Priscilla T, Luttman, Charlotte A, Saunders, Royal D, Ruterbories, Kenneth J

“…Three homologous series of 3,5-dialkoxy-4-hydroxybenzylamines were prepared and tested (1) as peroxyl radical scavengers in homogeneous aqueous solution, (2)…”
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The pharmacokinetics of indecainide in mice, rats, dogs, and monkeys by Lindstrom, T D, Whitaker, G W

“…The pharmacokinetics of indecainide, a new antiarrhythmic agent, were studied in mice, rats, dogs, and monkeys. The drug was well absorbed in all species…”
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Alpha, beta-ketoalkene reduction. A novel reduction pathway in mammalian tissues by Lindstrom, T D, Whitaker, G W

“…Reduction of an alpha, beta-unsaturated ketone to the corresponding saturated ketone in a 2-benzylidene-3-ketocoumaran derivative has been characterized with…”
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Metabolism of the antiarrhythmic agent, indecainide, in rats, dogs, and monkeys by Lindstrom, T D, Lacefield, W B, Whitaker, G W

“…The biotransformation of indecainide, a potent new antiarrhythmic agent, has been studied in rats and dogs. Indecainide was excreted in the urine primarily as…”
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Saturation of an alpha, beta-unsaturated ketone: a novel xenobiotic biotransformation in mammals by Lindstrom, T D, Whitaker, G W

“…Reduction of an alpha, beta-unsaturated ketone to the corresponding saturated ketone in a 2-benzylidene-3-ketocoumaran derivative has been investigated…”
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Correlation between the disposition of [14C]clofilium and its cardiac electrophysiological effect by Lindstrom, T D, Murphy, P J, Smallwood, J K, Wiest, S A, Steinberg, M I

“…The disposition of [14C]clofilium was studied in rats and dogs and related to the electrophysiological effects observed in isolated canine Purkinje fibers. Ten…”
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