Search Results - "LINDSLEY, Stacey R"

Inferior-Medial Dry Needling at the Thoracolumbar Junction: A Cadaveric Study by Williams, Christi L, Curfman, Sue E, Lindsley, Stacey R, Falyar, Christian R, McConnell, Ryan C

“…Dry needling (DN) has emerged as a popular therapeutic intervention for managing musculoskeletal pain. While major adverse events are generally rare, those…”
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Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors by Lindsley, Stacey R., Moore, Keith P., Rajapakse, Hemaka A., Selnick, Harold G., Young, Mary Beth, Zhu, Hong, Munshi, Sanjeev, Kuo, Lawrence, McGaughey, Georgia B., Colussi, Dennis, Crouthamel, Ming-Chih, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Simon, Adam J., Seabrook, Guy R., Hazuda, Daria J., Pudvah, Nicole T., Hochman, Jerome H., Graham, Samuel L., Vacca, Joseph P., Nantermet, Philippe G.

“…This Letter describes the design and synthesis of tertiary carbinamine macrocyclic inhibitors of the β-secretase (BACE-1) enzyme. These macrocyclic inhibitors,…”
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Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model by Jones, Carrie K, Engers, Darren W, Thompson, Analisa D, Field, Julie R, Blobaum, Anna L, Lindsley, Stacey R, Zhou, Ya, Gogliotti, Rocco D, Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R

“…There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric…”
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Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1) by Rajapakse, Hemaka A, Nantermet, Philippe G, Selnick, Harold G, Munshi, Sanjeev, McGaughey, Georgia B, Lindsley, Stacey R, Young, Mary Beth, Lai, Ming-Tain, Espeseth, Amy S, Shi, Xiao-Ping, Colussi, Dennis, Pietrak, Beth, Crouthamel, Ming-Chih, Tugusheva, Katherine, Huang, Qian, Xu, Min, Simon, Adam J, Kuo, Lawrence, Hazuda, Daria J, Graham, Samuel, Vacca, Joseph P

“…We describe the discovery and optimization of tertiary carbinamine derived inhibitors of the enzyme β-secretase (BACE-1). These novel…”
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Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype by Rodriguez, Alice L., Williams, Richard, Zhou, Ya, Lindsley, Stacey R., Le, Uyen, Grier, Mark D., David Weaver, C., Jeffrey Conn, P., Lindsley, Craig W.

“…This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu(5) using a functional cell-based assay is described in…”
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SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition by RAJAPAKSE, Hemaka A, NANTERMET, Philippe G, LAI, Ming-Tain, ESPESETH, Amy S, SHI, Xiao-Ping, COLUSSI, Dennis, PIETRAK, Beth, CROUTHAMEL, Ming-Chih, TUGUSHEVA, Katherine, QIAN HUANG, MIN XU, SIMON, Adam J, SELNICK, Harold G, KUO, Lawrence, HAZUDA, Daria J, GRAHAM, Samuel, VACCA, Joseph P, BARROW, James C, MCGAUGHEY, Georgia B, MUNSHI, Sanjeev, LINDSLEY, Stacey R, YOUNG, Mary Beth, NGO, Phung L, KATHERINE HOLLOWAY, M

“…The optimization of tertiary carbinamine derived inhibitors of BACE1 from its discovery as an unstable lead to low nanomolar cell active compounds is…”
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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P 1 ′ group by Nantermet, Philippe G, Barrow, James C, Lindsley, Stacey R, Young, MaryBeth, Mao, Shi-Shan, Carroll, Steven, Bailey, Carolyn, Bosserman, Michele, Colussi, Dennis, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G

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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S., Lindsley, Stacey R., Lamb, Jeffrey P., Rodriguez, Alice L., Menon, Usha N., Jadhav, Satyawan, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu5 using a functional cell-based assay is described in…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu sub(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, PJeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu sub(5) using a functional cell-based assay is described…”
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Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an anti-Parkinsonian Animal Model by Jones, Carrie K., Engers, Darren W., Thompson, Analisa D., Field, Julie R., Blobaum, Anna L., Lindsley, Stacey R., Zhou, Ya, Gogliotti, Rocco D., Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.

“…There is an increasing amount of literature data showing the positive effects on preclinical anti-Parkinsonian rodent models with selective positive allosteric…”
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SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pK sub(a) in enzyme inhibition by Rajapakse, Hemaka A, Nantermet, Philippe G, Selnick, Harold G, Barrow, James C, McGaughey, Georgia B, Munshi, Sanjeev, Lindsley, Stacey R, Young, Mary Beth, Ngo, Phung L, Holloway, MKatherine, Lai, Ming-Tain, Espeseth, Amy S, Shi, Xiao-Ping, Colussi, Dennis, Pietrak, Beth, Crouthamel, Ming-Chih, Tugusheva, Katherine, Huang, Qian, Xu, Min, Simon, Adam J, Kuo, Lawrence, Hazuda, Daria J, Graham, Samuel, Vacca, Joseph P

“…The optimization of tertiary carbinamine derived inhibitors of BACE1 from its discovery as an unstable lead to low nanomolar cell active compounds is…”
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SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine p K a in enzyme inhibition by Rajapakse, Hemaka A., Nantermet, Philippe G., Selnick, Harold G., Barrow, James C., McGaughey, Georgia B., Munshi, Sanjeev, Lindsley, Stacey R., Young, Mary Beth, Ngo, Phung L., Katherine Holloway, M., Lai, Ming-Tain, Espeseth, Amy S., Shi, Xiao-Ping, Colussi, Dennis, Pietrak, Beth, Crouthamel, Ming-Chih, Tugusheva, Katherine, Huang, Qian, Xu, Min, Simon, Adam J., Kuo, Lawrence, Hazuda, Daria J., Graham, Samuel, Vacca, Joseph P.

“…This Letter describes SAR of the tertiary carbinamine derived inhibitors of BACE1 revealed during the optimization of the unstable lead toward potent and…”
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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group by Nantermet, Philippe G, Barrow, James C, Lindsley, Stacey R, Young, MaryBeth, Mao, Shi-Shan, Carroll, Steven, Bailey, Carolyn, Bosserman, Michele, Colussi, Dennis, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G

“…Structural modifications of the aminopyridine P(1)(') group of imidazole acetic acid based TAFIa inhibitors led to the discovery of the aminocyclopentyl analog…”
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Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P'1 group by NANTERMET, Philippe G, BARROW, James C, VACCA, Joseph P, SELNICK, Harold G, LINDSLEY, Stacey R, YOUNG, Marybeth, MAO, Shi-Shan, CARROLL, Steven, BAILEY, Carolyn, BOSSERMAN, Michele, COLUSSI, Dennis, MCMASTERS, Daniel R

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