Search Results - "LINDHOUT, Theresa"
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Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes
Published in Proceedings of the National Academy of Sciences - PNAS (03-05-2011)“…The posttranslational modification of therapeutic proteins with terminal sialic acids is one means of improving their circulating half-life, thereby improving…”
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Differential Lipopolysaccharide Core Capping Leads to Quantitative and Correlated Modifications of Mechanical and Structural Properties in Pseudomonas aeruginosa Biofilms
Published in Journal of Bacteriology (01-11-2009)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Truncation in the core oligosaccharide of lipopolysaccharide affects flagella-mediated motility in Pseudomonas aeruginosa PAO1 via modulation of cell surface attachment
Published in Microbiology (Society for General Microbiology) (01-10-2009)“…1 Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada 2 Mass Spectrometry Facility, University of Guelph, Guelph, ON…”
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Biochemical characterization of a polysialyltransferase from Mannheimia haemolytica A2 and comparison to other bacterial polysialyltransferases
Published in PloS one (26-07-2013)“…Polysialic acids are bioactive carbohydrates found in eukaryotes and some bacterial pathogens. The bacterial polysialyltransferases (PSTs), which catalyze the…”
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Enzymatic Engineering of Polysialic Acid on Cells in Vitro and in Vivo Using a Purified Bacterial Polysialyltransferase
Published in The Journal of biological chemistry (21-09-2012)“…In vertebrates, polysialic acid (PSA) is typically added to the neural cell adhesion molecule (NCAM) in the Golgi by PST or STX polysialyltransferase. PSA…”
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Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae
Published in The Journal of immunology (1950) (15-06-2020)“…deploys a unique immune evasion strategy wherein the lacto- -neotetraose termini of lipooligosaccharide (LOS) are "capped" by a surface LOS sialyltransferase…”
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Biochemical Characterization of a Polysialyltransferase from Mannheimia haemolytica A2 and Comparison to Other Bacterial Polysialyltransferases. e69888
Published in PloS one (01-07-2013)“…Polysialic acids are bioactive carbohydrates found in eukaryotes and some bacterial pathogens. The bacterial polysialyltransferases (PSTs), which catalyze the…”
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Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins
Published in The Journal of infectious diseases (15-11-2020)“…Abstract Novel therapies to counteract multidrug-resistant gonorrhea are urgently needed. A unique gonococcal immune evasion strategy involves capping of…”
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