Search Results - "LINDEN, MELISSA A"

eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH by Sheldon, Ryan D, Meers, Grace M, Morris, E Matthew, Linden, Melissa A, Cunningham, Rory P, Ibdah, Jamal A, Thyfault, John P, Laughlin, M Harold, Rector, R Scott

“…Dysregulated mitochondrial quality control leads to mitochondrial functional impairments that are central to the development and progression of hepatic…”
Get more information

The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes by Linden, Melissa A., Ross, Trenton T., Beebe, David A., Gorgoglione, Matthew F., Hamilton, Karyn L., Miller, Benjamin F., Braun, Barry, Esler, William P.

“…Exercise is recommended in addition to pharmacotherapies for the management of type 2 diabetes, but metformin and exercise training may have non-additive or…”
Get full text

Impact of Various Exercise Modalities on Hepatic Mitochondrial Function by FLETCHER, JUSTIN A, MEERS, GRACE M, LINDEN, MELISSA A, KEARNEY, MONICA L, MORRIS, E MATTHEW, THYFAULT, JOHN P, RECTOR, R SCOTT

“…PURPOSEHepatic mitochondrial adaptations to exercise are largely unknown. In this study, we sought to determine the effects of various exercise modalities on…”
Get full text

Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension by Musci, Robert V, Hamilton, Karyn L, Linden, Melissa A

“…Oxidative damage is one mechanism linking aging with chronic diseases including the progressive loss of skeletal muscle mass and function called sarcopenia…”
Get full text

Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats by Ortinau, Laura C., Linden, Melissa A., Dirkes, Rebecca K., Rector, R. Scott, Hinton, Pamela S.

“…The present study extends our previous findings that exercise, which prevents the onset of insulin resistance and type 2 diabetes (T2D), also prevents the…”
Get full text

Aerobic exercise training in the treatment of non‐alcoholic fatty liver disease related fibrosis by Linden, Melissa A., Sheldon, Ryan D., Meers, Grace M., Ortinau, Laura C., Morris, E. Matthew, Booth, Frank W., Kanaley, Jill A., Vieira‐Potter, Victoria J., Sowers, James R., Ibdah, Jamal A., Thyfault, John P., Laughlin, M. Harold, Rector, R. Scott

“…Key points Physiologically relevant rodent models of non‐alcoholic steatohepatitis (NASH) that resemble the human condition are limited. Exercise training and…”
Get full text

Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats by Linden, Melissa A, Fletcher, Justin A, Morris, E Matthew, Meers, Grace M, Kearney, Monica L, Crissey, Jacqueline M, Laughlin, M Harold, Booth, Frank W, Sowers, James R, Ibdah, Jamal A, Thyfault, John P, Rector, R Scott

“…Here, we sought to compare the efficacy of combining exercise and metformin for the treatment of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD)…”
Get more information

Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations by Fletcher, Justin A, Linden, Melissa A, Sheldon, Ryan D, Meers, Grace M, Morris, E Matthew, Butterfield, Anthony, Perfield, 2nd, James W, Thyfault, John P, Rector, R Scott

“…Exercise stimulates hepatic mitochondrial adaptations; however, the mechanisms remain largely unknown. Here we tested whether FGF21 plays an obligatory role in…”
Get more information

The effects of high fat diet and moderate exercise on TGFβ1 and collagen deposition in mouse skeletal muscle by Pincu, Yair, Linden, Melissa A., Zou, Kai, Baynard, Tracy, Boppart, Marni D.

“…•High fat diet increased F4/80 and IL-6 gene expression in skeletal muscle.•Exercise suppressed the elevation of F4/80 and IL-6 mRNA with high fat diet.•High…”
Get full text

Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration by Linden, Melissa A., Burke, Susan J., Pirzadah, Humza A., Huang, Tai-Yu, Batdorf, Heidi M., Mohammed, Walid K., Jones, Katarina A., Ghosh, Sujoy, Campagna, Shawn R., Collier, J. Jason, Noland, Robert C.

“…Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced)…”
Get full text

A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats by Linden, Melissa A, Fletcher, Justin A, Meers, Grace M, Thyfault, John P, Laughlin, M Harold, Rector, R Scott

“…Hyperphagic Otsuka Long-Evans Tokushima fatty (OLETF) rats develop obesity, insulin resistance, and nonalcoholic fatty liver disease (NAFLD), but lifestyle…”
Get more information

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction by Martinez, Wenceslao, Zhang, Qian, Linden, Melissa A, Schacher, Nate, Darvish, Sanna, Mirek, Emily T, Levy, Jordan L, Jonsson, William O, Anthony, Tracy G, Hamilton, Karyn L

“…Dietary interventions such as sulfur amino acid restriction (SAAR) target multiple drivers of aging, and show promise for preventing or delaying the onset of…”
Get full text

Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle by Romero, Matthew A, Mobley, C Brooks, Linden, Melissa A, Meers, Grace Margaret-Eleanor, Martin, Jeffrey S, Young, Kaelin C, Rector, R Scott, Roberts, Michael D

“…The purpose of this study was to examine if: (a) high sugar/high fat Western diet (WD)-feeding affects skeletal muscle ribosome biogenesis markers in…”
Get full text

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults by Konopka, Adam R., Laurin, Jaime L., Schoenberg, Hayden M., Reid, Justin J., Castor, William M., Wolff, Christopher A., Musci, Robert V., Safairad, Oscar D., Linden, Melissa A., Biela, Laurie M., Bailey, Susan M., Hamilton, Karyn L., Miller, Benjamin F.

“…Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy…”
Get full text

Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin by Reid, Justin J, Linden, Melissa A, Peelor, Frederick F, Miller, Richard A, Hamilton, Karyn L, Miller, Benjamin F

“…Abstract Treatment with the mechanistic target of rapamycin (mTOR) inhibitor, rapamycin (RAP), alone and in combination with the antidiabetic drug, metformin…”
Get full text

Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex by Jonsson, William O, Margolies, Nicholas S, Mirek, Emily T, Zhang, Qian, Linden, Melissa A, Hill, Cristal M, Link, Christopher, Bithi, Nazmin, Zalma, Brian, Levy, Jordan L, Pettit, Ashley P, Miller, Joshua W, Hine, Christopher, Morrison, Christopher D, Gettys, Thomas W, Miller, Benjamin F, Hamilton, Karyn L, Wek, Ronald C, Anthony, Tracy G

“…Dietary sulfur amino acid restriction (SAAR) improves body composition and metabolic health across several model organisms in part through induction of the…”
Get more information

Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training by LINDEN, MELISSA A, FLETCHER, JUSTIN A, MORRIS, E MATTHEW, MEERS, GRACE M, LAUGHLIN, M HAROLD, BOOTH, FRANK W, SOWERS, JAMES R, IBDAH, JAMAL A, THYFAULT, JOHN P, RECTOR, R SCOTT

“…BACKGROUNDThere is increasing use of high-intensity interval-type exercise training in the management of many lifestyle-related diseases. PURPOSEThis study…”
Get full text

Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline by Musci, Robert V., Andrie, Kendra M., Walsh, Maureen A., Valenti, Zackary J., Linden, Melissa A., Afzali, Maryam F., Bork, Sydney, Campbell, Margaret, Johnson, Taylor, Kail, Thomas E., Martinez, Richard, Nguyen, Tessa, Sanford, Joseph, Wist, Sara, Murrell, Meredith D., McCord, Joe M., Hybertson, Brooks M., Zhang, Qian, Javors, Martin A., Santangelo, Kelly S., Hamilton, Karyn L.

“…Impaired mitochondrial function and disrupted proteostasis contribute to musculoskeletal dysfunction. However, few interventions simultaneously target these…”
Get full text

Exercise and Weight Loss Improve Exercise Capacity Independent of Cardiac Function in Metabolic Syndrome by Chockalingam, Anand, Linden, Melissa A., Del Rosario, Marc, Govindarajan, Gurushankar, Dellsperger, Kevin C., Thomas, Tom R.

“…Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss…”
Get full text

Obesity and type 2 diabetes, not a diet high in fat, sucrose, and cholesterol, negatively impacts bone outcomes in the hyperphagic Otsuka Long Evans Tokushima Fatty rat by Ortinau, Laura C., Linden, Melissa A., Dirkes, Rebecca, Rector, R. Scott, Hinton, Pamela S.

“…Obesity and type 2 diabetes (T2D) increase fracture risk; however, the association between obesity/T2D may be confounded by consumption of a diet high in fat,…”
Get full text