Search Results - "LINDEMAN, Neal"

Pathomic Fusion: An Integrated Framework for Fusing Histopathology and Genomic Features for Cancer Diagnosis and Prognosis by Chen, Richard J., Lu, Ming Y., Wang, Jingwen, Williamson, Drew F. K., Rodig, Scott J., Lindeman, Neal I., Mahmood, Faisal

“…Cancer diagnosis, prognosis, mymargin and therapeutic response predictions are based on morphological information from histology slides and molecular profiles…”
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Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion by Chakravarty, Debyani, Johnson, Amber, Sklar, Jeffrey, Lindeman, Neal I, Moore, Kathleen, Ganesan, Shridar, Lovly, Christine M, Perlmutter, Jane, Gray, Stacy W, Hwang, Jimmy, Lieu, Christopher, André, Fabrice, Azad, Nilofer, Borad, Mitesh, Tafe, Laura, Messersmith, Hans, Robson, Mark, Meric-Bernstam, Funda

“…An ASCO provisional clinical opinion offers timely clinical direction to ASCO's membership following publication or presentation of potentially…”
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Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies by Kluk, Michael J, Lindsley, R. Coleman, Aster, Jon C, Lindeman, Neal I, Szeto, David, Hall, Dimity, Kuo, Frank C

“…Targeted next-generation sequencing panels to identify genetic alterations in cancers are increasingly becoming an integral part of clinical practice. We…”
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Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists by Li, Marilyn M, Datto, Michael, Duncavage, Eric J, Kulkarni, Shashikant, Lindeman, Neal I, Roy, Somak, Tsimberidou, Apostolia M, Vnencak-Jones, Cindy L, Wolff, Daynna J, Younes, Anas, Nikiforova, Marina N

“…Widespread clinical laboratory implementation of next-generation sequencing-based cancer testing has highlighted the importance and potential benefits of…”
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Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer by Garcia, Elizabeth P, Minkovsky, Alissa, Jia, Yonghui, Ducar, Matthew D, Shivdasani, Priyanka, Gong, Xin, Ligon, Azra H, Sholl, Lynette M, Kuo, Frank C, MacConaill, Laura E, Lindeman, Neal I, Dong, Fei

“…- The analysis of somatic mutations across multiple genes in cancer specimens may be used to aid clinical decision making. The analytical validation of…”
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Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J, Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc

“…To establish evidence-based recommendations for the molecular analysis of lung cancers that are that are required to guide EGFR- and ALK-directed therapies,…”
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MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges by Mansouri, Alireza, Hachem, Laureen D, Mansouri, Sheila, Nassiri, Farshad, Laperriere, Normand J, Xia, Daniel, Lindeman, Neal I, Wen, Patrick Y, Chakravarti, Arnab, Mehta, Minesh P, Hegi, Monika E, Stupp, Roger, Aldape, Kenneth D, Zadeh, Gelareh

“…Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor, with a universally poor prognosis. The emergence of molecular biomarkers has had…”
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Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next Generation Sequencing by Nowak, Jonathan A, Yurgelun, Matthew B, Bruce, Jacqueline L, Rojas-Rudilla, Vanesa, Hall, Dimity L, Shivdasani, Priyanka, Garcia, Elizabeth P, Agoston, Agoston T, Srivastava, Amitabh, Ogino, Shuji, Kuo, Frank C, Lindeman, Neal I, Dong, Fei

“…Mismatch repair protein deficiency (MMR-D) and high microsatellite instability (MSI-H) are features of Lynch syndrome–associated colorectal carcinomas and have…”
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Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer by Barroso-Sousa, Romualdo, Keenan, Tanya E, Pernas, Sonia, Exman, Pedro, Jain, Esha, Garrido-Castro, Ana C, Hughes, Melissa, Bychkovsky, Brittany, Umeton, Renato, Files, Janet L, Lindeman, Neal I, MacConaill, Laura E, Hodi, F Stephen, Krop, Ian E, Dillon, Deborah, Winer, Eric P, Wagle, Nikhil, Lin, Nancy U, Mittendorf, Elizabeth A, Van Allen, Eliezer M, Tolaney, Sara M

“…Few patients with metastatic triple-negative breast cancer (mTNBC) benefit from immune checkpoint inhibitors (ICI). On the basis of immunotherapy response…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…- In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and…”
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Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J, Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc

“…To establish evidence-based recommendations for the molecular analysis of lung cancers that are required to guide EGFR- and ALK-directed therapies, addressing…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the…”
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Worldwide Frequency of Commonly Detected EGFR Mutations by Graham, Rondell P, Treece, Amanda L, Lindeman, Neal I, Vasalos, Patricia, Shan, Mu, Jennings, Lawrence J, Rimm, David L

“…- Recurrent epidermal growth factor receptor ( EGFR) mutations are seen in a subset of pulmonary adenocarcinomas. These mutations are targeted by EGFR…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the…”
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Phase II Study of Avelumab in Patients With Mismatch Repair Deficient and Mismatch Repair Proficient Recurrent/Persistent Endometrial Cancer by Konstantinopoulos, Panagiotis A, Luo, Weixiu, Liu, Joyce F, Gulhan, Doga C, Krasner, Carolyn, Ishizuka, Jeffrey J, Gockley, Allison A, Buss, Mary, Growdon, Whitfield B, Crowe, Heather, Campos, Susana, Lindeman, Neal I, Hill, Sarah, Stover, Elizabeth, Schumer, Susan, Wright, Alexi A, Curtis, Jennifer, Quinn, Roxanne, Whalen, Christin, Gray, Kathryn P, Penson, Richard T, Cannistra, Stephen A, Fleming, Gini F, Matulonis, Ursula A

“…Despite the tissue-agnostic approval of pembrolizumab in mismatch repair deficient (MMRD) solid tumors, important unanswered questions remain about the role of…”
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Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions by Oxnard, Geoffrey R, Lo, Peter C, Nishino, Mizuki, Dahlberg, Suzanne E, Lindeman, Neal I, Butaney, Mohit, Jackman, David M, Johnson, Bruce E, Jänne, Pasi A

“…Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non-small-cell lung cancer (NSCLC). Little is…”
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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations by Lindsley, R. Coleman, Mar, Brenton G., Mazzola, Emanuele, Grauman, Peter V., Shareef, Sarah, Allen, Steven L., Pigneux, Arnaud, Wetzler, Meir, Stuart, Robert K., Erba, Harry P., Damon, Lloyd E., Powell, Bayard L., Lindeman, Neal, Steensma, David P., Wadleigh, Martha, DeAngelo, Daniel J., Neuberg, Donna, Stone, Richard M., Ebert, Benjamin L.

“…Acute myeloid leukemia (AML) can develop after an antecedent myeloid malignancy (secondary AML [s-AML]), after leukemogenic therapy (therapy-related AML…”
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Clinical and Technical Aspects of Genomic Diagnostics for Precision Oncology by Sheikine, Yuri, Kuo, Frank C, Lindeman, Neal I

“…The emergence of precision medicine has been predicated on significant recent advances in diagnostic technology, particularly the advent of next-generation…”
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MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction by Xu, Lian, Hunter, Zachary R., Yang, Guang, Zhou, Yangsheng, Cao, Yang, Liu, Xia, Morra, Enrica, Trojani, Alessandra, Greco, Antonino, Arcaini, Luca, Varettoni, Marzia, Brown, Jennifer R., Tai, Yu-Tzu, Anderson, Kenneth C., Munshi, Nikhil C., Patterson, Christopher J., Manning, Robert J., Tripsas, Christina K., Lindeman, Neal I., Treon, Steven P.

“…By whole-genome and/or Sanger sequencing, we recently identified a somatic mutation (MYD88 L265P) that stimulates nuclear factor κB activity and is present in…”
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BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers by Abo, Ryan P, Ducar, Matthew, Garcia, Elizabeth P, Thorner, Aaron R, Rojas-Rudilla, Vanesa, Lin, Ling, Sholl, Lynette M, Hahn, William C, Meyerson, Matthew, Lindeman, Neal I, Van Hummelen, Paul, MacConaill, Laura E

“…Genomic structural variation (SV), a common hallmark of cancer, has important predictive and therapeutic implications. However, accurately detecting SV using…”
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