Search Results - "LINCOLN, THOMAS"

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription by Jeong, Kyuho, Kim, Jung-Hyun, Murphy, James M, Park, Hyeonsoo, Kim, Su-Jeong, Rodriguez, Yelitza A.R, Kong, Hyunkyung, Choi, Chungsik, Guan, Jun-Lin, Taylor, Joan M, Lincoln, Thomas M, Gerthoffer, William T, Kim, Jun-Sub, Ahn, Eun-Young Erin, Schlaepfer, David D, Lim, Ssang-Taek Steve

“…RATIONALE:Neointimal hyperplasia is characterized by excessive accumulation of vascular smooth muscle cells (SMCs) leading to occlusive disorders, such as…”
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KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells by Sellak, Hassan, Wu, Songwei, Lincoln, Thomas M.

“…The transcriptional activator β-catenin is a key mediator of the canonical Wnt signaling pathway. β-catenin itself does not bind DNA but functions via…”
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Myosin Phosphatase Regulatory Pathways: Different Functions or Redundant Functions? by Lincoln, Thomas M

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MicroRNA-145 Restores Contractile Vascular Smooth Muscle Phenotype and Coronary Collateral Growth in the Metabolic Syndrome by Hutcheson, Rebecca, Terry, Russell, Chaplin, Jennifer, Smith, Erika, Musiyenko, Alla, Russell, James C, Lincoln, Thomas, Rocic, Petra

“…OBJECTIVE—Transient, repetitive occlusion stimulates coronary collateral growth (CCG) in normal animals. Vascular smooth muscle cells (VSMCs) switch to…”
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Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency by Chettimada, Sukrutha, Joshi, Sachindra Raj, Dhagia, Vidhi, Aiezza, 2nd, Alessandro, Lincoln, Thomas M, Gupte, Rakhee, Miano, Joseph M, Gupte, Sachin A

“…Homeostatic control of vascular smooth muscle cell (VSMC) differentiation is critical for contractile activity and regulation of blood flow. Recently, we…”
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Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase by Lincoln, Thomas M, Wu, Xing, Sellak, Hassan, Dey, Nupur, Choi, Chung-Sik

“…This basic science review examines the role of cGMP and cGMP-dependent protein kinase (PKG) in the regulation of vascular smooth muscle cell (VSMC) phenotype…”
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Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression by Lincoln, T M, Dey, N, Sellak, H

“…cGMP is a second messenger that produces its effects by interacting with intracellular receptor proteins. In smooth muscle cells, one of the major receptors…”
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Transcriptional regulation of α1H T-type calcium channel under hypoxia by Sellak, Hassan, Zhou, Chun, Liu, Bainan, Chen, Hairu, Lincoln, Thomas M, Wu, Songwei

“…The low-voltage-activated T-type Ca(2+) channels play an important role in mediating the cellular responses to altered oxygen tension. Among three T-type…”
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Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria by Costa, Alexandre D.T, Garlid, Keith D, West, Ian C, Lincoln, Thomas M, Downey, James M, Cohen, Michael V, Critz, Stuart D

“…Ischemic and pharmacological preconditioning can be triggered by an intracellular signaling pathway in which Gi-coupled surface receptors activate a cascade…”
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Possible involvement of Cyclic-GMP-dependent protein kinase on matrix metalloproteinase-2 expression in rat aortic smooth muscle cells by Dey, Nupur B., Lincoln, Thomas M.

“…Degradation and resynthesis of the extracellular matrix (ECM) are essential during tissue remodeling. Expansion of the vascular intima in atherosclerosis and…”
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Glc-6-PD and PKG contribute to hypoxia-induced decrease in smooth muscle cell contractile phenotype proteins in pulmonary artery by Chettimada, Sukrutha, Rawat, Dhwajbahadur K, Dey, Nupur, Kobelja, Robert, Simms, Zachary, Wolin, Michael S, Lincoln, Thomas M, Gupte, Sachin A

“…Persistent hypoxic pulmonary vasoconstriction (HPV) plays a significant role in the pathogenesis of pulmonary hypertension, which is an emerging clinical…”
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Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species by Liu, Shu, Ma, Xueying, Gong, Mingcui, Shi, Lihua, Lincoln, Thomas, Wang, Shuxia

“…Reduced levels of cGMP-dependent protein kinase I (PKG-I) in vasculature have been shown to contribute to diabetic vascular dysfunctions. However, the…”
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cGMP-dependent protein kinase and the regulation of vascular smooth muscle cell gene expression: possible involvement of Elk-1 sumoylation by Choi, ChungSik, Sellak, Hassan, Brown, Felricia M, Lincoln, Thomas M

“…Although the regulation of smooth muscle cell (SMC) gene expression by cGMP-dependent protein kinase (PKG) is now recognized, the mechanisms underlying these…”
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An evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone by Vagenas, Panagiotis, Ph.D., M.P.H, Di Paola, Angela, M.S, Herme, Maua, M.P.H, Lincoln, Thomas, M.D, Skiest, Daniel J., M.D, Altice, Frederick L., M.D., M.A, Springer, Sandra A., M.D

“…Abstract Extended-release naltrexone (XR-NTX), an approved treatment for opioid or alcohol dependence, is a once-monthly injectable formulation of naltrexone…”
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Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance by Sellak, Hassan, Choi, Chung-sik, Dey, Nupur B, Lincoln, Thomas M

“…The ability of the endothelium to produce nitric oxide, which induces generation of cyclic guanosine monophosphate (cGMP) that activates cGMP-dependent protein…”
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Stabilization of cGMP-dependent protein kinase G (PKG) expression in vascular smooth muscle cells: contribution of 3'UTR of its mRNA by Sellak, Hassan, Lincoln, Thomas M, Choi, Chung-Sik

“…The type-I cGMP-dependent protein kinase (PKG-I) expression regulation is not yet completely understood. In this study, we examined the role of 3'-untranslated…”
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Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries by Thorpe, Richard B, Stockman, Sara L, Williams, James M, Lincoln, Thomas M, Pearce, William J

“…Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G…”
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Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries by Pearce, William J, Williams, James M, White, Charles R, Lincoln, Thomas M

“…1 Departments of Physiology, Pharmacology, and Biochemistry, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California;…”
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Mechanism of Platelet Inhibition by Nitric Oxide: In vivo Phosphorylation of Thromboxane Receptor by Cyclic GMP-Dependent Protein Kinase by Wang, Guang-Rong, Zhu, Yan, Halushka, Perry V., Lincoln, Thomas M., Mendelsohn, Michael E.

“…Nitric oxide (NO) is a potent vasodilator and inhibitor of platelet activation. NO stimulates production of cGMP and activates cGMP-dependent protein kinase (G…”
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Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells by Browner, Natasha C, Sellak, Hassan, Lincoln, Thomas M

“…NO and cGMP have antigrowth and anti-inflammatory effects on the vessel wall in response to injury. It is well established that after vascular injury…”
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