Search Results - "LIMAS, C"

Evidence that the human cell cycle is a series of uncoupled, memoryless phases by Chao, Hui Xiao, Fakhreddin, Randy I, Shimerov, Hristo K, Kedziora, Katarzyna M, Kumar, Rashmi J, Perez, Joanna, Limas, Juanita C, Grant, Gavin D, Cook, Jeanette Gowen, Gupta, Gaorav P, Purvis, Jeremy E

“…The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2, and M. In single cells, the duration of each phase varies, but the…”
Get full text

Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a by Justice, Megan, Bryan, Audra F, Limas, Juanita C, Cook, Jeanette Gowen, Dowen, Jill M

“…The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin…”
Get full text

The molecular architecture of cell cycle arrest by Stallaert, Wayne, Taylor, Sovanny R, Kedziora, Katarzyna M, Taylor, Colin D, Sobon, Holly K, Young, Catherine L, Limas, Juanita C, Varblow Holloway, Jonah, Johnson, Martha S, Cook, Jeanette Gowen, Purvis, Jeremy E

“…The cellular decision governing the transition between proliferative and arrested states is crucial to the development and function of every tissue. While the…”
Get full text

The spectrum of primary cutaneous elastolytic granulomas and their distinction from granuloma annulare: a clinicopathological analysis by Limas, C

“…Aims:  Actinic granuloma (AG) and annular elastolytic giant cell granuloma (AEGCG) are terms commonly applied to cutaneous lesions characterized by…”
Get full text

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition by McNeill, Robert S, Stroobant, Emily E, Smithberger, Erin, Canoutas, Demitra A, Butler, Madison K, Shelton, Abigail K, Patel, Shrey D, Limas, Juanita C, Skinner, Kasey R, Bash, Ryan E, Schmid, Ralf S, Miller, C Ryan

“…Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense…”
Get full text

Preparation for DNA replication: the key to a successful S phase by Limas, Juanita C., Cook, Jeanette Gowen

“…Successful genome duplication is required for cell proliferation and demands extraordinary precision and accuracy. The mechanisms by which cells enter,…”
Get full text

Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI by Grant, Gavin D., Kedziora, Katarzyna M., Limas, Juanita C., Cook, Jeanette Gowen, Purvis, Jeremy E.

“…Cell cycle phase transitions are tightly orchestrated to ensure efficient cell cycle progression and genome stability. Interrogating these transitions is…”
Get full text

Recurrent dermatitis after solitary envenomation by jellyfish partially responded to tacrolimus ointment 0.1 by Rallis, E, Limas, C

Get full text

Autoantibodies Against β-Adrenoceptors in Human Idiopathic Dilated Cardiomyopathy by Limas, Constantinos J, Goldenberg, Irvin F, Limas, Catherine

“…Although it is recognized that the number of cardiac β-adrenoceptors is reduced in human dilated cardiomyopathy, the mechanisms involved have not been defined…”
Get full text

The Impact of Research Culture on Mental Health & Diversity in STEM by Limas, Juanita C., Corcoran, Linda C., Baker, Alexander N., Cartaya, Ana E., Ayres, Zoë J.

“…The onset of COVID‐19, coupled with the finer lens placed on systemic racial disparities within our society, has resulted in increased discussions around…”
Get full text

Soluble interleukin-2 receptor levels in patients with dilated cardiomyopathy : correlation with disease severity and cardiac autoantibodies by LIMAS, C. J, GOLDENBERG, I. F, LIMAS, C

“…There is evidence that autoimmunity plays an important role in the initiation and progression of myocardial injury in dilated cardiomyopathy. Abnormalities of…”
Get full text

Beta-adrenoceptor antibodies and genetics in dilated cardiomyopathy--an overview and review by Limas, C J, Limas, C

“…Autoantibodies against the cardiac beta-adrenoceptor are present in 30-40% of patients with idiopathic dilated cardiomyopathy and can be detected using ligand…”
Get more information

Cardiac autoantibodies in dilated cardiomyopathy: a pathogenetic role? by Limas, C J

Get full text

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K by Wells, Carrow, Couñago, Rafael M, Limas, Juanita C, Almeida, Tuanny L, Cook, Jeanette Gowen, Drewry, David H, Elkins, Jonathan M, Gileadi, Opher, Kapadia, Nirav R, Lorente-Macias, Alvaro, Pickett, Julie E, Riemen, Alexander, Ruela-de-Sousa, Roberta R, Willson, Timothy M, Zhang, Cunyu, Zuercher, William J, Zutshi, Reena, Axtman, Alison D

“…Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule…”
Get full text

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma by McNeill, Robert S, Canoutas, Demitra A, Stuhlmiller, Timothy J, Dhruv, Harshil D, Irvin, David M, Bash, Ryan E, Angus, Steven P, Herring, Laura E, Simon, Jeremy M, Skinner, Kasey R, Limas, Juanita C, Chen, Xin, Schmid, Ralf S, Siegel, Marni B, Van Swearingen, Amanda E D, Hadler, Michael J, Sulman, Erik P, Sarkaria, Jann N, Anders, Carey K, Graves, Lee M, Berens, Michael E, Johnson, Gary L, Miller, C Ryan

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Prognosis remains poor despite multimodal therapy. Developing alternative treatments…”
Get full text

Prognostic significance of soluble interleukin-2 receptor levels in patients with dilated cardiomyopathy by Limas, C. J., Hasikidis, C., Iakovou, J., Kroupis, C., Haidaroglou, A., Cokkinos, D. V.

“…Background Activation of T lymphocytes is thought to mediate myocardial dysfunction in dilated cardiomyopathy (CMP), probably through cytotoxic cytokines, but…”
Get full text

Hyperprolactinaemia in patients with heart failure: clinical and immunogenetic correlations by Limas, C. J., Kroupis, C., Haidaroglou, A., Cokkinos, D. V.

“…Background Prolactin represents a stimulatory link between the neuroendocrine and immune systems, but its involvement in the neurohumoral adaptations to heart…”
Get full text

Rapid Recovery of Cardiac β-Adrenergic Receptors after Isoproterenol-Induced “Down”-Regulation by Limas, Constantinos J, Limas, Catherine

“…Desensitization of β-receptor-linked adenylate cyclase occurs after prolonged occupancy of the /8-receptors by their agonists. We have followed the development…”
Get full text

Soluble interleukin-2 receptor: is there a role in ischaemic cardiomyopathy? Authors' reply by Limas, C. J., Cokkinos, D. V.

Get full text

Quantitative profiling of adaptation to cyclin E overproduction by Limas, Juanita C, Littlejohn, Amiee N, House, Amy M, Kedziora, Katarzyna M, Mouery, Brandon L, Ma, Boyang, Fleifel, Dalia, Walens, Andrea, Aleman, Maria M, Dominguez, Daniel, Cook, Jeanette Gowen

“…Cyclin E/CDK2 drives cell cycle progression from G1 to S phase. Despite the toxicity of cyclin E overproduction in mammalian cells, the cyclin E gene is…”
Get full text