Search Results - "LIMA, Andréa C"

Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders by Louzada, Paulo Roberto, Lima, Andréa C. Paula, Mendonca‐Silva, Dayde L., Noël, Francois, De Mello, Fernando G., Ferreira, Sérgio T.

“…Alzheimer's disease (AD) and several other neurological disorders have been linked to the overactivation of glutamatergic transmission and exci‐totoxicity as a…”
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Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease by Paula‐Lima, Andrea C., Brito‐Moreira, Jordano, Ferreira, Sergio T.

“…Alzheimer′s disease (AD) is the most common form of dementia in the elderly. Memory loss in AD is increasingly attributed to soluble oligomers of the amyloid‐β…”
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Development and Evaluation of Praziquantel Solid Dispersions in Sodium Starch Glycolate by Chaud, Marco V, Lima, Andréa C, Vila, Marta MDC, Paganelli, Maria O, Paula, Fábio C, Pedreiro, Liliane N, Gremião, Maria PD

“…Purpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ…”
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Periodontal bacteria in the brain—Implication for Alzheimer's disease: A systematic review by Parra‐Torres, Valeria, Melgar‐Rodríguez, Samanta, Muñoz‐Manríquez, Constanza, Sanhueza, Benjamín, Cafferata, Emilio A., Paula‐Lima, Andrea C., Díaz‐Zúñiga, Jaime

“…Periodontitis is a chronic non‐communicable disease caused by a dysbiotic microbiota. Pathogens can spread to the bloodstream, colonize other tissues or…”
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LC Evaluation of Intestinal Transport of Praziquantel by Cinto, Priscila O, Souza, Ana Luiza Ribeiro, Lima, Andréa C, Chaud, Marco V, Gremião, Maria Palmira D

“…Praziquantel (PZQ) is a highly lipophilic drug with low aqueous solubility. Despite this, it is well absorbed from the gastrointestinal tract. In this study, a…”
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The effects of levodopa in the spatiotemporal gait parameters are mediated by self‐selected gait speed in Parkinson's disease by Ávila de Oliveira, Júlia, Bazán, Paulo Rodrigo, Oliveira, Claudia Eunice Neves, Treza, Renata de Castro, Hondo, Sandy Mikie, Los Angeles, Emanuele, Bernardo, Claudionor, Oliveira, Luana dos Santos, Carvalho, Margarete de Jesus, Lima‐Pardini, Andrea C., Coelho, Daniel Boari

“…In individuals with Parkinson's disease (PD), the medication induces different and inconsistent results in the spatiotemporal parameters of gait, making it…”
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Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: potential redox modulation by Paula-Lima, Andrea C, Adasme, Tatiana, Hidalgo, Cecilia

“…Memory is an essential human cognitive function. Consequently, to unravel the cellular and molecular mechanisms responsible for the synaptic plasticity events…”
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Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity by Paula-Lima, Andréa C., Tricerri, M. Alejandra, Brito-Moreira, Jordano, Bomfim, Theresa R., Oliveira, Fabio F., Magdesian, Margaret H., Grinberg, Lea T., Panizzutti, Rogerio, Ferreira, Sérgio T.

“…Aggregates of the amyloid-β peptide (Aβ) play a central role in the pathogenesis of Alzheimer's disease (AD). Identification of proteins that physiologically…”
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Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line by Paula Lima, Andréa C, Arriagada, Christian, Toro, Rodrigo, Cárdenas, Ana María, Caviedes, Raúl, Ferreira, Sergio T, Caviedes, Pablo

“…We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the beta-amyloid peptide and its neurotoxicity in…”
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Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease by Salech, Felipe, Ponce, Daniela P., Paula-Lima, Andrea C., SanMartin, Carol D., Behrens, María I.

“…Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal…”
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Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation by Adasme, Tatiana, Haeger, Paola, Paula-Lima, Andrea C, Espinoza, Italo, Casas-Alarcón, M. Mercedes, Carrasco, M. Angélica, Hidalgo, Cecilia

“…Ryanodine receptors (RyR) amplify activity-dependent calcium influx via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in…”
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RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers by SanMartín, Carol D., Veloso, Pablo, Adasme, Tatiana, Lobos, Pedro, Bruna, Barbara, Galaz, Jose, García, Alejandra, Hartel, Steffen, Hidalgo, Cecilia, Paula-Lima, Andrea C.

“…Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer´s disease, trigger persistent and low magnitude Ca2+ signals in neurons…”
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Activation of GABA A receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons by Paula-Lima, Andréa C., De Felice, Fernanda G., Brito-Moreira, Jordano, Ferreira, Sérgio T.

“…The β-amyloid peptide (Aβ) is centrally related to the pathogenesis of Alzheimer's disease (AD) and is potently neurotoxic to central nervous system neurons…”
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Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics? by Paula-Lima, Andrea C., Hidalgo, Cecilia

“…[...]some evidence implicates activation of these enzymes by AβOs-generated Ca2+ signals. [...]inhibition of the PKC pathway reduces the cell death induced by…”
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Keeping your balance while balancing a cylinder: interaction between postural and voluntary goals by Papegaaij, Selma, de Lima-Pardini, Andrea C., Smith, Beth A., Otten, Egbert, Cohen, Rajal G., Horak, Fay B.

“…The present study investigated whether postural responses are influenced by the stability constraint of a voluntary, manual task. We also examined how task…”
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Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons by SanMartín, Carol D., Paula-Lima, Andrea C., García, Alejandra, Barattini, Pablo, Hartel, Steffen, Núñez, Marco T., Hidalgo, Cecilia

“…Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to…”
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Spinal Cord Stimulation for Freezing of Gait: From Bench to Bedside by Fonoff, Erich Talamoni, de Lima-Pardini, Andrea C, Coelho, Daniel Boari, Monaco, Bernardo Assumpção, Machado, Birajara, Pinto de Souza, Carolina, Dos Santos Ghilardi, Maria Gabriela, Hamani, Clement

“…Spinal cord stimulation (SCS) has been used for the treatment of chronic pain for nearly five decades. With a high degree of efficacy and a low incidence of…”
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The zymogen‐enteropeptidase system: A practical approach to study the regulation of enzyme activity by proteolytic cleavage by Pizauro, João M., Ferro, Jesus A., de Lima, Andréa C. F., Routman, Karina S., Portella, Maria Célia

“…The present research describes an efficient procedure to obtain high levels of trypsinogen and chymotrypsinogen by using a simple, rapid, and easily…”
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Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content by Muñoz, Yorka, Paula-Lima, Andrea C., Núñez, Marco T.

“…The transcription factor STAT3 has a crucial role in the development and maintenance of the nervous system. In this work, we treated astrocytes with oligomers…”
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Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF by Paula-Lima, Andrea C, Adasme, Tatiana, SanMartín, Carol, Sebollela, Adriano, Hetz, Claudio, Carrasco, M Angélica, Ferreira, Sergio T, Hidalgo, Cecilia

“…Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and…”
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