Mycobacterium tuberculosis infection in pediatric liver transplant recipients

OBJECTIVES. METHODS. RESULTS.Mycobacterium tuberculosis infection occurred in 6 of 254 (2.4%) children undergoing liver transplantation between 1991 and 1998. Cough, pyrexia and poor appetite were common presentations; one-half had normal chest radiographs. The median time to confirmation of diagnos...

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Bibliographic Details
Published in:	The Pediatric infectious disease journal Vol. 19; no. 7; pp. 625 - 630
Main Authors:	VERMA, ANITA, DHAWAN, ANIL, WADE, JIM J, LIM, WAH H, RUIZ, GARY, PRICE, JOHN F, HADZIC, NEDIM, BAKER, ALASTAIR J, RELA, MOHEMMED, HEATON, NIGEL D, MIELI-VERGANI, GIORGINA
Format:	Journal Article
Language:	English
Published:	Baltimore, MD Copyright Wolters Kluwer Health, Inc. All rights reserved 01-07-2000 Philadelphia, PA Lippincott Hagerstown, MD
Subjects:	Adolescent Antitubercular Agents - adverse effects Bacterial diseases Biological and medical sciences Chemical and Drug Induced Liver Injury - etiology Child, Preschool Hemorrhage - etiology Human bacterial diseases Humans Incidence Infant Infectious diseases Isoniazid - adverse effects Liver Transplantation Medical sciences Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Polymerase Chain Reaction Postoperative Complications - epidemiology Postoperative Complications - microbiology Retrospective Studies Sepsis - etiology Staining and Labeling Tuberculosis - complications Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis and atypical mycobacterial infections Prognosis Toxicity Liver Transplantation Mycobacterial infection Homotransplantation Incidence Surgery Bacteria Antituberculous agent Diagnosis Child Human Method Infection Symptomatology Chemotherapy Treatment Tuberculosis Mycobacterium tuberculosis Mycobacteriales Bacteriosis Mycobacteriaceae Actinomycetes Antibacterial agent Inaugural sign
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Summary:	OBJECTIVES. METHODS. RESULTS.Mycobacterium tuberculosis infection occurred in 6 of 254 (2.4%) children undergoing liver transplantation between 1991 and 1998. Cough, pyrexia and poor appetite were common presentations; one-half had normal chest radiographs. The median time to confirmation of diagnosis was 8 months (range, 1 to 17 months). Tests contributing to diagnosis includedZiehl-Neelsen (ZN) stain (2 patients), M. tuberculosis polymerase chain reaction (1 patient), Mantoux test (1 patient) and histopathology (4 patients). Family health screening was productive for 4 patients. Duration of treatment varied from 9 to 18 months. Isoniazid-induced hepatitis was observed in 2 patients but resolved with dose reduction. Two patients died while receiving treatment, one of Klebsiella spp. septicemia and the other of pulmonary hemorrhage. CONCLUSIONS.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-200007000-00008