Search Results - "LIM, Tony K. Y"

CysPresso: a classification model utilizing deep learning protein representations to predict recombinant expression of cysteine-dense peptides by Ouellet, Sébastien, Ferguson, Larissa, Lau, Angus Z, Lim, Tony K Y

“…Cysteine-dense peptides (CDPs) are an attractive pharmaceutical scaffold that display extreme biochemical properties, low immunogenicity, and the ability to…”
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Mitochondrial and Bioenergetic Dysfunction in Trauma-Induced Painful Peripheral Neuropathy by Lim, Tony K. Y., Rone, Malena B., Lee, Seunghwan, Antel, Jack P., Zhang, Ji

“…Background Mitochondrial dysfunction is observed in various neuropathic pain phenotypes, such as chemotherapy induced neuropathy, diabetic neuropathy,…”
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The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo by LIM, Tony K. Y, MACLEOD, Bernard A, RIES, Craig R, SCHWARZ, Stephan K. W

“…QX-314 is a quaternary lidocaine derivative considered to be devoid of clinically useful local anesthetic activity. However, several reports document that…”
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Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief by Lim, Tony K.Y., Shi, Xiang Qun, Martin, Hiliary Claire, Huang, Hao, Luheshi, Giamal, Rivest, Serge, Zhang, Ji

“…Nerve injury leads to a persistent disruption of the blood-nerve barrier, which allows the entrance of blood-borne pronociceptive molecules and cells,…”
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Statins alleviate experimental nerve injury-induced neuropathic pain by Shi, Xiang Qun, Lim, Tony K.Y., Lee, Seunghwan, Zhao, Yuan Qing, Zhang, Ji

“…The statins are a well-established class of drugs that lower plasma cholesterol levels by inhibiting HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A)…”
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Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain by Lim, Tony K Y, Shi, Xiang Q, Johnson, Julia M, Rone, Malena B, Antel, Jack P, David, Samuel, Zhang, Ji

“…Nerve injury is associated with microvascular disturbance; however, the role of the vascular system has not been well characterized in the context of…”
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Microglial trogocytosis and the complement system regulate axonal pruning in vivo by Lim, Tony Ky, Ruthazer, Edward S

“…Partial phagocytosis-called trogocytosis-of axons by microglia has been documented in ex vivo preparations but has not been directly observed in vivo. The…”
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Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid by Lim, Tony K Y, Anderson, Kathleen M, Hari, Pawan, Di Falco, Marcos, Reihsen, Troy E, Wilcox, George L, Belani, Kumar G, LaBoissiere, Sylvie, Pinto, Manuel R, Beebe, David S, Kehl, Lois J, Stone, Laura S

“…Intervertebral disc degeneration (DD) is a cause of low back pain (LBP) in some individuals. However, although >30% of adults have DD, LBP only develops in a…”
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Can modulating inflammatory response be a good strategy to treat neuropathic pain? by Zhang, Ji, Echeverry, Stefania, Lim, Tony K Y, Lee, Seung Hwan, Shi, Xiang Qun, Huang, Hao

“…Neuronal injury not only results in severe alteration in the function of primary sensory neurons and their central projection pathway, but is also associated…”
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Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders by Symons, Frank J, Wolff, Jason J, Stone, Laura S, Lim, Tony K Y, Bodfish, James W

“…Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured…”
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Peripheral Nerve Injury Induces Persistent Vascular Dysfunction and Endoneurial Hypoxia, Contributing to the Genesis of Neuropathic Pain by Lim, Tony KY, Shi, Xiang Q, Johnson, Julia M, Rone, Malena B, Antel, Jack P, David, Samuel, Zhang, Ji

“…Nerve injury is associated with microvascular disturbance; however, the role of the vascular system has not been well characterized in the context of…”
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Proteomic analysis of human cerebrospinal fluid from patients with painful and non-painful degenerative disc disease by Lim, Tony K. Y

“…One of the primary causes of persistent lumbar back pain is degenerative disc disease (DDD). In most persons, DDD is a normal process occurring with natural…”
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