Search Results - "LILLINGTON, Debra M"

Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias by RAGHAVAN, Manoj, LILLINGTON, Debra M, SKOULAKIS, Spyros, DEBERNARDI, Silvana, CHAPLIN, Tracy, FOOT, Nicola J, LISTER, T. Andrew, YOUNG, Bryan D

“…Genome-wide analysis of single nucleotide polymorphisms in 64 acute myeloid leukemias has revealed that approximately 20% exhibited large regions of…”
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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) by Akasaka, Takashi, Balasas, Theodore, Russell, Lisa J., Sugimoto, Kei-ji, Majid, Aneela, Walewska, Renata, Karran, E. Loraine, Brown, David G., Cain, Kelvin, Harder, Lana, Gesk, Stefan, Martin-Subero, Jose Ignacio, Atherton, Mark G., Brüggemann, Monika, Calasanz, María José, Davies, Teresa, Haas, Oskar A., Hagemeijer, Anne, Kempski, Helena, Lessard, Michel, Lillington, Debra M., Moore, Sarah, Nguyen-Khac, Florence, Radford-Weiss, Isabelle, Schoch, Claudia, Struski, Stéphanie, Talley, Polly, Welham, Melanie J., Worley, Helen, Strefford, Jon C., Harrison, Christine J., Siebert, Reiner, Dyer, Martin J.S.

“…CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid…”
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Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease by Paulsson, Kajsa, Cazier, Jean-Baptiste, MacDougall, Finlay, Stevens, Jane, Stasevich, Irina, Vrcelj, Nikoletta, Chaplin, Tracy, Lillington, Debra M, Lister, T. Andrew, Young, Bryan D

“…We present here a genome-wide map of abnormalities found in diagnostic samples from 45 adults and adolescents with acute lymphoblastic leukemia (ALL). A 500K…”
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Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia by Raghavan, Manoj, Smith, Lan-Lan, Lillington, Debra M., Chaplin, Tracy, Kakkas, Ioannis, Molloy, Gael, Chelala, Claude, Cazier, Jean-Baptiste, Cavenagh, James D., Fitzgibbon, Jude, Lister, T. Andrew, Young, Bryan D.

“…Despite advances in the curative treatment of acute myeloid leukemia (AML), recurrence will occur in the majority of cases. At diagnosis, acquisition of…”
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Differential gene expression in pituitary adenomas by oligonucleotide array analysis by Morris, Damian G, Muşat, Mädälina, Czirják, Sándor, Hanzély, Zoltán, Lillington, Debra M, Korbonits, Márta, Grossman, Ashley B

“…Objectives: Microarray technology allows for the expression profile of many thousands of genes to be quantified at the same time, and has resulted in novel…”
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11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop by Bloomfield, Clara D., Archer, Kellie J., Mrózek, Krzysztof, Lillington, Debra M., Kaneko, Yasuhiko, Head, David R., Dal Cin, Paola, Raimondi, Susana C.

“…Among 511 patients with therapy‐related myelodysplastic syndrome or acute leukemia (t‐MDS/t‐AL) and balanced chromosome aberrations, 162 (32%) had…”
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Molecular cytogenetic characterization of Sézary syndrome by Mao, Xin, Lillington, Debra M., Czepulkowski, Barbara, Russell-Jones, Robin, Young, Bryan D., Whittaker, Sean

“…Sézary syndrome (SS) is a rare form of erythrodermic cutaneous T‐cell lymphoma with hematological involvement and a poor prognosis. At present little is known…”
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Detection of Chromosome Abnormalities Pre–High-Dose Treatment in Patients Developing Therapy-Related Myelodysplasia and Secondary Acute Myelogenous Leukemia After Treatment for Non-Hodgkin’s Lymphoma by LILLINGTON, Debra M, MICALLEF, Ivana N. M, CARPENTER, Emily, NEAT, Michael J, AMESS, John A. L, MATTHEWS, Janet, FOOT, Nicola J, YOUNG, Bryan D, LISTER, T. Andrew, ROHATINER, Ama Z. S

“…To assess whether pre-high-dose therapy (HDT)-related factors play a critical role in the development of therapy-related myelodysplasia (tMDS) or secondary…”
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Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes by Haferlach, Claudia, Rieder, Harald, Lillington, Debra M., Dastugue, Nicole, Hagemeijer, Anne, Harbott, Jochen, Stilgenbauer, Stephan, Knuutila, Sakari, Johansson, Bertil, Fonatsch, Christa

“…The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has…”
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Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas by Mao, Xin, Orchard, Guy, Lillington, Debra M., Russell-Jones, Robin, Young, Bryan D., Whittaker, Sean J.

“…Primary cutaneous lymphomas (PCLs) represent a heterogeneous group of extranodal T- and B-cell malignancies. The underlying molecular pathogenesis of this…”
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Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events by Debernardi, Silvana, Lillington, Debra M., Chaplin, Tracy, Tomlinson, Simon, Amess, John, Rohatiner, Ama, Lister, T. Andrew, Young, Bryan D.

“…Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML)…”
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Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma by Mao, Xin, Orchard, Guy, Lillington, Debra M., Russell-Jones, Robin, Young, Bryan D., Whittaker, Sean

“…Primary cutaneous CD30+ anaplastic large cell lymphoma (C‐ALCL) represents a distinct clinical subtype of CD30+ anaplastic large cell lymphomas. The etiology…”
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Therapy-Related Myelodysplasia and Secondary Acute Myelogenous Leukemia After High-Dose Therapy With Autologous Hematopoietic Progenitor-Cell Support for Lymphoid Malignancies by MICALLEF, I. N. M, LILLINGTON, D. M, ROHATINER, A. Z. S, APOSTOLIDIS, J, AMESS, J. A. L, NEAT, M, MATTHEWS, J, CLARK, T, FORAN, J. M, SALAM, A, LISTER, T. A

“…To evaluate the incidence of and risk factors for therapy-related myelodysplasia (tMDS) and secondary acute myelogenous leukemia (sAML), after high-dose…”
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Comparative genomic hybridization of 49 primary retinoblastoma tumors identifies chromosomal regions associated with histopathology, progression, and patient outcome by Lillington, Debra M., Kingston, Judith E., Coen, Pietro G., Price, Elizabeth, Hungerford, John, Domizio, Paola, Young, Bryan D., Onadim, Zerrin

“…Forty‐nine primary retinoblastoma (Rb) tumors were analyzed by the use of comparative genomic hybridization (CGH), and clinical/histological correlations were…”
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Genomic Alterations in Blastic Natural Killer/Extranodal Natural Killer-Like T Cell Lymphoma with Cutaneous Involvement by Mao, Xin, Onadim, Zerrin, Price, Elizabeth A., Child, Fiona, Lillington, Debra M., Russell-Jones, Robin, Young, Bryan D., Whittaker, Sean

“…Natural killer and natural killer-like T cell lymphomas represent a rare type of non-Hodgkin's lymphoma originally described to involve the upper aerodigestive…”
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Upregulation of lipocortin 1 inhibits tumour necrosis factor-induced apoptosis in human leukaemic cells : a possible mechanism of resistance to immune surveillance by WU, Yu-Ling, JIANG, Xu-Rong, LILLINGTON, Debra M, NEWLAND, Adrian C, KELSEY, Stephen M

“…The signal transduction pathway through which tumour necrosis factor (TNF) induces apoptosis in leukaemic cells may involve activation of cytosolic…”
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Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis by BEVERLOO, H. B, LE CONIAT, M, BERGER, R, WIJSMAN, J, LILLINGTON, D. M, BERNARD, O, DE KLEIN, A, VAN WERING, E, WELBORN, J, YOUNG, B. D, HAGEMEIJER, A

“…Ten AML-M4/M5 patients' samples containing a t(10;11) translocation, but with different cytogenetic breakpoints on chromosome 11q (11q13-23), were studied by…”
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Molecular cloning of a constitutional t(7;22) translocation associated with risk of hematological malignancy by Hill, Alexander S., MacCallum, Peter K., Young, Bryan D., Lillington, Debra M.

“…We report the molecular characterization of a reciprocal constitutional translocation t(7;22)(p13;q11.2) carried by three family members who have each…”
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Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia by Lillington, Debra M., Jaju, Rina J., Shankar, A. G., Neat, Michael, Kearney, Lyndal, Young, Bryan D., Saha, Vaskar

“…A diagnosis of granulocytic sarcoma was made in a 2‐year‐old child based on the detection of myelomonocytic blasts in tissue obtained from a subcutaneous…”
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Upregulation of lipocortin 1 inhibits tumour necrosis factor‐induced apoptosis in human leukaemic cells: a possible mechanism of resistance to immune surveillance by Wu, Yu‐Ling, Jiang, Xu‐Rong, Lillington, Debra M., Newland, Adrian C., Kelsey, Stephen M.

“…The signal transduction pathway through which tumour necrosis factor (TNF) induces apoptosis in leukaemic cells may involve activation of cytosolic…”
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