Search Results - "LILLEYMAN, J"

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial by Mitchell, C. D., Richards, S. M., Kinsey, S. E., Lilleyman, J., Vora, A., Eden, T. O. B.

“…Summary Corticosteroids are an essential component of treatment for acute lymphoblastic leukaemia (ALL). Prednisolone is the most commonly used steroid,…”
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Management of childhood idiopathic thrombocytopenic purpura by Lilleyman, John S.

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Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia by Lilleyman, J S, Lennard, L

“…Many months' treatment with daily oral mercaptopurine is an important part of therapy for nearly all children with lymphoblastic leukaemia (ALL). Even when…”
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Intracranial haemorrhage in idiopathic thrombocytopenic purpura by LILLEYMAN, J. S

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Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997 by EDEN, O. B, HARRISON, G, RICHARDS, S, LILLEYMAN, J. S, BAILEY, C. C, CHESSELLS, J. M, HANN, I. M, HILL, F. G. H, GIBSON, B. E. S

“…Results of three consecutive completed UK trials (1980-1997) for childhood lymphoblastic leukaemia are presented. National accrual has progressively increased…”
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Human thiopurine methyltransferase activity varies with red blood cell age by Lennard, L., Chew, T. S., Lilleyman, J. S.

“…Aims  Inherited differences in thiopurine methyltransferase (TPMT) activity are an important factor in the wide interindividual variations observed in the…”
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Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia by LANCASTER, D. L, PATEL, N, LENNARD, L, LILLEYMAN, J. S

“…The aim of this study was to compare leucocyte and erythrocyte thioguanine nucleotide (TGN) cytotoxic metabolite concentrations in children with lymphoblastic…”
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Informed decision making: an annotated bibliography and systematic review by Bekker, H, Thornton, J G, Airey, C M, Connelly, J B, Hewison, J, Robinson, M B, Lilleyman, J, MacIntosh, M, Maule, A J, Michie, S, Pearman, A D

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Progressive reduction in treatment‐related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI) by Hargrave, D. R., Hann, I. M., Richards, S. M., Hill, F. G., Lilleyman, J. S., Kinsey, S., Bailey, C. C., Chessells, J. M., Mitchell, C., Eden, O. B.

“…In the last 20 years, the survival rate for children with acute lymphoblastic leukaemia (ALL) has markedly improved, largely owing to a decrease in relapses…”
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Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia by Lennard, L, Gibson, B E, Nicole, T, Lilleyman, J S

“…Two children with acute lymphoblastic leukaemia (ALL) taking daily 6-mercaptopurine as part of a national UK therapeutic trial repeatedly developed profound…”
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Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia by Lennard, L, Lilleyman, J S

“…Intracellular thioguanine nucleotides (6-TGN) are the major cytotoxic metabolites of mercaptopurine (6-MP). Red blood cell (RBC) 6-TGN concentrations were…”
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Profile of non-compliance in lymphoblastic leukaemia by Lancaster, D, Lennard, L, Lilleyman, J S

“…A nationwide study of intracellular drug metabolite concentrations in children prescribed 6-mercaptopurine for the treatment of lymphoblastic leukaemia was…”
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Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia by Lennard, L, Lilleyman, J S, Van Loon, J, Weinshilboum, R M

“…6-mercaptopurine (6-MP) can be inactivated by S-methylation, which is catalysed by thiopurine methyltransferase (TPMT). An alternative metabolic route leads to…”
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Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity by Lennard, L., Welch, J. C., Lilleyman, J. S.

“…Aims The response to 6‐mercaptopurine (6MP) is highly variable. Its antileukaemic effect can be related to drug derived 6‐thioguanine nucleotides (TGNs). The…”
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6‐Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6‐thioguanine nucleotide concentrations by Lancaster, D. L., Patel, N., Lennard, L., Lilleyman, J. S.

“…Aims  Since relatively little is known about the pharmacokinetics of 6‐thioguanine (6TG) in children receiving 6‐thioguanine for maintenance therapy of acute…”
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Blood and Bone Marrow Pathology by Lilleyman, J. S.

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Implementing the district hospital recommendations for the National Health Service Research Ethics Service in England by Wisely, J, Lilleyman, J

“…[...]these views are not as incompatible as they might first appear…”
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Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance? by LENNARD, L, WELCH, J, LILLEYMAN, J. S

“…As part of a programme assessing the pharmacokinetics of oral thiopurines given for lymphoblastic leukaemia, we assayed intracellular metabolites of…”
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Benefit of intensified treatment for all children with acute lymphoblastic leukaemia : results from MRC UKALL XI and MRC ALL97 randomised trials by HANN, I, VORA, A, RICHARDS, S, HILL, F, GIBSON, B, LILLEYMAN, J, KINSEY, S, MITCHELL, C, EDEN, O. B

“…Treatment of children with acute lymphoblastic leukaemia (ALL) aims to cure all patients with as little toxicity as possible and, if possible, to restrict…”
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Reflecting on Redfern: What can we learn from the Alder Hey story? by HALL, DAVID

“…In 1998 the General Medical Council (GMC) charged two Bristol surgeons and their medical director with misconduct on the grounds that they had failed to…”
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