Search Results - "LILIOM, KAROLY"

Dual coding in alternative reading frames correlates with intrinsic protein disorder by Kovacs, Erika, Tompa, Peter, Liliom, Karoly, Kalmar, Lajos

“…Numerous human genes display dual coding within alternatively spliced regions, which give rise to distinct protein products that include segments translated in…”
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Sphingosylphosphorylcholine as a novel calmodulin inhibitor by Kovacs, Erika, Liliom, Karoly

“…S1P (sphingosine 1-phosphate) and SPC (sphingosylphosphorylcholine) have been recently recognized as important mediators of cell signalling, regulating basic…”
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The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S] by Bolen, Alyssa L., Naren, Anjaparavanda P., Yarlagadda, Sunitha, Beranova-Giorgianni, Sarka, Chen, Li, Norman, Derek, Baker, Daniel L., Rowland, Meng M., Best, Michael D., Sano, Takamitsu, Tsukahara, Tamotsu, Liliom, Karoly, Igarashi, Yasuyuki, Tigyi, Gabor

“…Platelet activation initiates an upsurge in polyun­saturated (18:2 and 20:4) lysophosphatidic acid (LPA) production. The biochemical pathway(s) responsible for…”
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Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions by Dürvanger, Zsolt, Juhász, Tünde, Liliom, Károly, Harmat, Veronika

“…Calmodulin (CaM) is a Ca2+ sensor protein found in all eukaryotic cells that regulates a large number of target proteins in a Ca2+ concentration-dependent…”
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Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate by Parrill, Abby L., Wang, De-an, Bautista, Debra L., Van Brocklyn, James R., Lorincz, Zsolt, Fischer, David J., Baker, Daniel L., Liliom, Karoly, Spiegel, Sarah, Tigyi, Gabor

“…Originating from its DNA sequence, a computational model of the Edg1 receptor has been developed that predicts critical interactions with its ligand,…”
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Competitive inhibition of the classical complement pathway using exogenous single-chain C1q recognition proteins by Vadászi, Henrietta, Kiss, Bence, Micsonai, András, Schlosser, Gitta, Szaniszló, Tamás, Kovács, Réka Á., Györffy, Balázs A., Kékesi, Katalin A., Goto, Yuji, Uzonyi, Barbara, Liliom, Károly, Kardos, József

“…Complement component 1q (C1q) is a protein complex of the innate immune system with well-characterized binding partners that constitutes part of the classical…”
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Enhancement of Sphingomyelinase-Induced Endothelial Nitric Oxide Synthase-Mediated Vasorelaxation in a Murine Model of Type 2 Diabetes by Ruisanchez, Éva, Janovicz, Anna, Panta, Rita Cecília, Kiss, Levente, Párkányi, Adrienn, Straky, Zsuzsa, Korda, Dávid, Liliom, Károly, Tigyi, Gábor, Benyó, Zoltán

“…Sphingolipids are important biological mediators both in health and disease. We investigated the vascular effects of enhanced sphingomyelinase (SMase) activity…”
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Absolute Quantitation of Serum Antibody Reactivity Using the Richards Growth Model for Antigen Microspot Titration by Papp, Krisztián, Kovács, Ágnes, Orosz, Anita, Hérincs, Zoltán, Randek, Judit, Liliom, Károly, Pfeil, Tamás, Prechl, József

“…In spite of its pivotal role in the characterization of humoral immunity, there is no accepted method for the absolute quantitation of antigen-specific serum…”
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Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors by Virag, Tamas, Elrod, Don B, Liliom, Karoly, Sardar, Vineet M, Parrill, Abby L, Yokoyama, Kazuaki, Durgam, Gangadhar, Deng, Wenlin, Miller, Duane D, Tigyi, Gabor

“…A more complete understanding of the physiological and pathological role of lysophosphatidic acid (LPA) requires receptor subtype-specific agonists and…”
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The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations by Juhász, Tünde, Mihály, Judith, Kohut, Gergely, Németh, Csaba, Liliom, Károly, Beke-Somfai, Tamás

“…Membrane-active, basic amphipathic peptides represent a class of biomolecules with diverse functions. Sequentially close protein segments also show similar…”
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Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding by Ecsédi, Péter, Kiss, Bence, Gógl, Gergő, Radnai, László, Buday, László, Koprivanacz, Kitti, Liliom, Károly, Leveles, Ibolya, Vértessy, Beáta, Jeszenői, Norbert, Hetényi, Csaba, Schlosser, Gitta, Katona, Gergely, Nyitray, László

“…Annexin A2 (ANXA2) has a versatile role in membrane-associated functions including membrane aggregation, endo- and exocytosis, and it is regulated by…”
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Comparison of ligand binding and conformational stability of human calmodulin with its homolog from the malaria parasite Plasmodium falciparum by Juhász, Tünde, Kardos, József, Dürvanger, Zsolt, Harmat, Veronika, Liliom, Károly

“…Calmodulin (CaM), the key calcium sensor of eukaryotic cells regulating a great number of target proteins, belongs to the most conserved proteins. We compared…”
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The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling by Koprivanacz, Kitti, Tőke, Orsolya, Besztercei, Balázs, Juhász, Tünde, Radnai, László, Merő, Balázs, Mihály, Judith, Péter, Mária, Balogh, Gábor, Vígh, László, Buday, László, Liliom, Károly

“…Src homology 3 or SH3 domains constitute one of the most common protein domains in signal transduction, generally characterized by their binding to…”
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Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding by Tőke, Orsolya, Koprivanacz, Kitti, Radnai, László, Merő, Balázs, Juhász, Tünde, Liliom, Károly, Buday, László

“…SH3 domains constitute an important class of protein modules involved in a variety of cellular functions. They participate in protein-protein interactions via…”
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Neonatal FcR overexpression boosts humoral immune response in transgenic mice by Cervenak, Judit, Bender, Balázs, Schneider, Zita, Magna, Melinda, Carstea, Bogdan Valer, Liliom, Károly, Erdei, Anna, Bosze, Zsuzsanna, Kacskovics, Imre

“…The neonatal FcR (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes active part in phagocytosis, and delivers Ag for…”
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Identification of the Hydrophobic Ligand Binding Pocket of the S1P1 Receptor by Fujiwara, Yuko, Osborne, Daniel A., Walker, Michelle D., Wang, De-an, Bautista, Debra A., Liliom, Karoly, Van Brocklyn, James R., Parrill, Abby L., Tigyi, Gabor

“…Sphingosine 1-phosphate (S1P), a naturally occurring sphingolipid mediator and also a second messenger with growth factor-like actions in almost every cell…”
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Soluble components of the flagellar export apparatus, FliI, FliJ, and FliH, do not deliver flagellin, the major filament protein, from the cytosol to the export gate by Sajó, Ráchel, Liliom, Károly, Muskotál, Adél, Klein, Ágnes, Závodszky, Péter, Vonderviszt, Ferenc, Dobó, József

“…Flagella, the locomotion organelles of bacteria, extend from the cytoplasm to the cell exterior. External flagellar proteins are synthesized in the cytoplasm…”
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Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control by Szabó, Judit E, Németh, Veronika, Papp-Kádár, Veronika, Nyíri, Kinga, Leveles, Ibolya, Bendes, Abris Á, Zagyva, Imre, Róna, Gergely, Pálinkás, Hajnalka L, Besztercei, Balázs, Ozohanics, Olivér, Vékey, Károly, Liliom, Károly, Tóth, Judit, Vértessy, Beáta G

“…Transfer of phage-related pathogenicity islands of Staphylococcus aureus (SaPI-s) was recently reported to be activated by helper phage dUTPases. This is a…”
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Pathogenic D76N Variant of β2-Microglobulin: Synergy of Diverse Effects in Both the Native and Amyloid States by Bulyáki, Éva, Kun, Judit, Molnár, Tamás, Papp, Alexandra, Micsonai, András, Vadászi, Henrietta, Márialigeti, Borbála, Kovács, Attila István, Gellén, Gabriella, Yamaguchi, Keiichi, Lin, Yuxi, So, Masatomo, Józsi, Mihály, Schlosser, Gitta, Lee, Young-Ho, Liliom, Károly, Goto, Yuji, Kardos, József

“…β2-microglobulin (β2m), the light chain of the MHC-I complex, is associated with dialysis-related amyloidosis (DRA). Recently, a hereditary systemic…”
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Selectivity of kinases on the activation of tenofovir, an anti-HIV agent by Varga, Andrea, Gráczer, Éva, Chaloin, Laurent, Liliom, Károly, Závodszky, Péter, Lionne, Corinne, Vas, Mária

“…Nucleoside analogues, used in HIV-therapy, need to be phosphorylated by cellular enzymes in order to become potential substrates for HIV reverse transcriptase…”
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