Search Results - "LILE, Joshua A"

Combining noninvasive brain stimulation with behavioral pharmacology methods to study mechanisms of substance use disorder by Wesley, Michael J, Lile, Joshua A

“…Psychotropic drugs and transcranial magnetic stimulation (TMS) are effective for treating certain psychiatric conditions. Drugs and TMS have also been used as…”
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An update on the clinical pharmacology of methylphenidate: therapeutic efficacy, abuse potential and future considerations by Shellenberg, Thomas P, Stoops, William W, Lile, Joshua A, Rush, Craig R

“…Methylphenidate remains a first-line medication for treating ADHD in children and adults. However, its behavioral pharmacological similarities to…”
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Differential sensitivity to learning from positive and negative outcomes in cocaine users by Strickland, Justin C, Bolin, B. Levi, Lile, Joshua A, Rush, Craig R, Stoops, William W

“…Highlights • Learning from positive and negative outcomes was tested in cocaine users. • Cocaine users showed decreased sensitivity to learning from positive…”
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546 Using Contingency Management to Understand the Cardiovascular, Immune and Psychosocial Benefits of Reduced Cocaine Use: A Protocol for a Randomized Controlled Trial by Regnier, Sean, Havens, Jennifer R., Shellenberg, Thomas P., Cox, David H., Baker, Thomas S., Lile, Joshua A., Rush, Craig R., Adatorwovor, Reuben, Hays, Lon R., Anderson, Danielle M., Fisher, Mary B., Segerstrom, Suzanne C., Schmitz, Joy M., Stoops, William W.

“…OBJECTIVES/GOALS: Contingency management (CM) procedures yield measurable reductions in cocaine use. This poster describes a trial aimed at using CM as a…”
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Evaluating non-medical prescription opioid demand using commodity purchase tasks: test-retest reliability and incremental validity by Strickland, Justin C., Lile, Joshua A., Stoops, William W.

“…Rationale Non-medical prescription opioid use and opioid use disorder (OUD) present a significant public health concern. Identifying behavioral mechanisms…”
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Utilizing the commodity purchase task to evaluate behavioral economic demand for illicit substances: a review and meta‐analysis by Strickland, Justin C., Campbell, Ethan M., Lile, Joshua A., Stoops, William W.

“…Background andAims The commodity purchase task is a simulated demand procedure that is easy and quick to complete (< 5 minutes) as well as adaptable for remote…”
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Unique prediction of cannabis use severity and behaviors by delay discounting and behavioral economic demand by Strickland, Justin C., Lile, Joshua A., Stoops, William W.

“…•Demand and delay discounting variables were measured in an online sample.•Cannabis users and controls did not differ in demand or delay…”
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Contribution of cannabis-related cues to concurrent reinforcer choice in humans by Strickland, Justin C., Lile, Joshua A., Stoops, William W.

“…•We evaluated the impact of cannabis cues on concurrent choice behavior.•A cannabis history group showed significant bias for cannabis-cued choices.•Cannabis…”
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Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal by Kumar, Mohit, Rainville, Jennifer R., Williams, Kori, Lile, Joshua A., Hodes, Georgia E., Vassoler, Fair M., Turner, Jill R.

“…Opioid use disorder is a leading cause of morbidity and mortality in the United States. Increasing pre-clinical and clinical evidence demonstrates sex…”
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The Subjective Value of Social Context in People Who Use Cannabis by Shellenberg, Thomas P., Strickland, Justin C., Bergeria, Cecilia L., Regnier, Sean D., Stoops, William W., Lile, Joshua A.

“…Disordered cannabis use is linked to social problems, which could be explained by a subjective devaluation of nondrug social contexts and/or an overvaluation…”
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A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl by Lile, Joshua A., Shellenberg, Thomas P., Babalonis, Shanna, Hatton, Kevin W., Hays, Lon R., Rayapati, Abner O., Stoops, William W., Wesley, Michael J.

“…Rationale Understanding mechanisms of drug use decisions will inform the development of treatments for opioid use disorder (OUD). Decision-making experiments…”
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Influence of cocaine use reduction on markers of immune function by Stoops, William W., Shellenberg, Thomas P., Regnier, Sean D., Cox, David H., Adatorwovor, Reuben, Hays, Lon R., Anderson, Danielle M., Lile, Joshua A., Schmitz, Joy M., Havens, Jennifer R., Segerstrom, Suzanne C.

“…This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week…”
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The state of clinical outcome assessments for cannabis use disorder clinical trials: A review and research agenda by Loflin, Mallory J.E., Kiluk, Brian D., Huestis, Marilyn A., Aklin, Will M., Budney, Alan J., Carroll, Kathleen M., D'Souza, Deepak Cyril, Dworkin, Robert H., Gray, Kevin M., Hasin, Deborah S., Lee, Dustin C., Le Foll, Bernard, Levin, Frances R., Lile, Joshua A., Mason, Barbara J., McRae-Clark, Aimee L., Montoya, Ivan, Peters, Erica N., Ramey, Tatiana, Turk, Dennis C., Vandrey, Ryan, Weiss, Roger D., Strain, Eric C.

“…•Provides a review of clinical outcome assessments for CUD trial endpoints.•Abstinence is not the only valid indicator of CUD treatment success.•A core toolkit…”
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Influence of n-acetylcysteine maintenance on the pharmacodynamic effects of oral ethanol by Stoops, William W., Strickland, Justin C., Hays, Lon R., Rayapati, Abner O., Lile, Joshua A., Rush, Craig R.

“…Glutamate systems play an important role in the abuse related effects of alcohol. n-Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a…”
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Suvorexant maintenance enhances the reinforcing but not subjective and physiological effects of intravenous cocaine in humans by Stoops, William W., Strickland, Justin C., Hatton, Kevin W., Hays, Lon R., Rayapati, Abner O., Lile, Joshua A., Rush, Craig R.

“…Preclinical research has sought to understand the role of the orexin system in cocaine addiction given the connection between orexin producing cells in the…”
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The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics by Lile, Joshua A, Wang, Zhixia, Woolverton, William L, France, Jessica E, Gregg, Timothy C, Davies, Huw M L, Nader, Michael A

“…This study was undertaken to investigate pharmacological variables that influence the reinforcing efficacy of psychostimulants. Rhesus monkeys (n = 9)…”
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Cocaine abstinence during the "critical period" of a contingency management trial predicts future abstinence in people with cocaine use disorder by Regnier, Sean D, Shellenberg, Thomas P, Koffarnus, Mikhail N, Cox, David H, Lile, Joshua A, Rush, Craig R, Stoops, William W

“…Contingency Management (CM) is being piloted as a treatment for stimulant use disorder in several US states, highlighting the need for treatment optimization…”
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Comparing Exponential and Exponentiated Models of Drug Demand in Cocaine Users by Strickland, Justin C, Lile, Joshua A, Rush, Craig R, Stoops, William W

“…Drug purchase tasks provide rapid and efficient measurement of drug demand. Zero values (i.e., prices with zero consumption) present a quantitative challenge…”
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Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation by Wesley, Michael J., Lile, Joshua A., Hanlon, Colleen A., Porrino, Linda J.

“…Rationale Long-term heavy cannabis users (cannabis users) who are not acutely intoxicated have diminished subconscious neural responsiveness to affective…”
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Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self‐administration studies by Regnier, Sean D., Lile, Joshua A., Rush, Craig R., Stoops, William W.

“…Cocaine use is an unrelenting public health concern. To inform intervention and prevention efforts, it is crucial to develop an understanding of the clinical…”
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