Search Results - "LIH KUO"

Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice by Hanaguri, Junya, Yokota, Harumasa, Watanabe, Masahisa, Yamagami, Satoru, Kushiyama, Akifumi, Kuo, Lih, Nagaoka, Taiji

“…We investigated and compared the susceptibility of retinal blood flow regulation and neural function in mice developing type 2 diabetes. The longitudinal…”
Get full text

H2O2 Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling by Thengchaisri, Naris, Kuo, Lih, Hein, Travis W.

“…In diabetes, the enzyme arginase is upregulated, which may compete with endothelial nitric oxide (NO) synthase (eNOS) for their common substrate L-arginine and…”
Get full text

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy by Hanaguri, Junya, Yokota, Harumasa, Watanabe, Masahisa, Kuo, Lih, Yamagami, Satoru, Nagaoka, Taiji

“…This study aimed to evaluate longitudinal changes in retinal blood flow in response to flicker stimulation and systemic hyperoxia in mice using a laser speckle…”
Get full text

Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes by Hein, Travis W, Omae, Tsuneaki, Xu, Wenjuan, Yoshida, Akitoshi, Kuo, Lih

“…Retinal vasomotor activity can be regulated by two major endothelial enzymes, nitric oxide synthase (NOS) and cyclooxygenase (COX). The vascular arginase also…”
Get full text

Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase by Chen, Yen-Lin, Ren, Yi, Xu, Wenjuan, Rosa, Jr, Robert H, Kuo, Lih, Hein, Travis W

“…Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in retinal venous pathologies such as diabetic retinopathy and retinal vein occlusion…”
Get full text

Activation of Coronary Arteriolar PKCβ2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation by Thengchaisri, Naris, Hein, Travis, Ren, Yi, Kuo, Lih

“…Protein kinase C (PKC) activation can evoke vasoconstriction and contribute to coronary disease. However, it is unclear whether PKC activation, without…”
Get full text

Safety and toxicity of nanomaterials for ocular drug delivery applications by Mehra, Neelesh K., Cai, Defu, Kuo, Lih, Hein, Travis, Palakurthi, Srinath

“…Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to facilitate safe and effective targeting with improved patient…”
Get full text

Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles by Hein, Travis W, Xu, Wenjuan, Xu, Xin, Kuo, Lih

“…Hyperglycemia, a hallmark of diabetes mellitus, is associated with retinal inflammation and impairment of endothelium-dependent nitric oxide (NO)-mediated…”
Get full text

Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger by Chen, Yen-Lin, Xu, Wenjuan, Rosa, Jr, Robert H, Kuo, Lih, Hein, Travis W

“…Diabetes is associated with hyperglycemia and impairment of retinal microvascular function. However, the impact of hyperglycemia on retinal venular…”
Get full text

Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase by Thengchaisri, Naris, Hein, Travis W, Ren, Yi, Kuo, Lih

“…Abstract Elevated levels of endothelin-1 (ET-1), a potent vasoactive peptide, are implicated as a risk factor for cardiovascular diseases by exerting…”
Get full text

Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo by Hein, Travis W, Singh, Uma, Vasquez-Vivar, Jeannette, Devaraj, Sridevi, Kuo, Lih, Jialal, Ishwarlal

“…Abstract Background and objective Elevated C-reactive protein (CRP) levels are associated with increased cardiovascular events and endothelial dysfunction. We…”
Get full text

Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function by Tsai, Shu-Huai, Xie, Wankun, Zhao, Min, Rosa, Robert H., Hein, Travis W., Kuo, Lih

“…Hypertension is associated with numerous diseases, but its direct impact on the ocular circulation and neuroretinal function remains unclear. Herein, mouse…”
Get full text

Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor by Otani, Shinichi, Nagaoka, Taiji, Omae, Tsuneaki, Tanano, Ichiro, Kamiya, Takayuki, Ono, Shinji, Hein, Travis W, Kuo, Lih, Yoshida, Akitoshi

“…Although endothelium-dependent nitric oxide (NO)-mediated dilation of retinal arterioles has been well described, the role of endothelium-derived…”
Get full text

Selective Activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Mediates C-Reactive Protein–Evoked Endothelial Vasodilator Dysfunction in Coronary Arterioles by Hein, Travis W, Qamirani, Erion, Ren, Yi, Xu, Xin, Thengchaisri, Naris, Kuo, Lih

“…RATIONALE:Studies in cultured endothelium implicate that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) or Fcγ receptor II (CD32) contributes…”
Get full text

Resveratrol, a Component of Red Wine, Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Potassium Channels by Nagaoka, Taiji, Hein, Travis W, Yoshida, Akitoshi, Kuo, Lih

“…Resveratrol, a polyphenolic phytoalexin found in grapes and red wine, has been shown to exert cardiovascular benefits, but its action in the retinal…”
Get full text

Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes by Hein, Travis W, Potts, Luke B, Xu, Wenjuan, Yuen, Josh Z, Kuo, Lih

“…Although hyperglycemia is implicated in retinal vascular dysfunction associated with the development of diabetic retinopathy, the temporal influence of…”
Get full text

Divergent Roles of Nitric Oxide and Rho Kinase in Vasomotor Regulation of Human Retinal Arterioles by Hein, Travis W, Rosa, Robert H., Jr, Yuan, Zhaoxu, Roberts, Elizabeth, Kuo, Lih

“…Although the arteriolar segment contributes to flow regulation, there is sparse information at the single microvessel level on how vasomotor function is…”
Get full text

Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase by Kuo, Lih, Hein, Travis W

“…Overproduction of reactive oxygen species, i.e., oxidative stress, is associated with the activation of redox signaling pathways linking to inflammatory…”
Get full text

Dilation of Retinal Arterioles in Response to Lactate: Role of Nitric Oxide, Guanylyl Cyclase, and ATP-Sensitive Potassium Channels by Hein, Travis W, Xu, Wenjuan, Kuo, Lih

“…Lactate, a key metabolite in the retinal tissue, has been implicated in regulating retinal blood flow to match retinal metabolic demand. However, the direct…”
Get full text

Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels by Potts, Luke B, Ren, Yi, Lu, Guangrong, Kuo, Enoch, Ngo, Ellen, Kuo, Lih, Hein, Travis W

“…Although endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in several retinal pathologies, the underlying mechanism of vasoconstriction is…”
Get full text