Search Results - "LIGHTMAN, S"

The Neuroendocrinology of Stress: A Never Ending Story by Lightman, S. L.

“…Evolutionary success depends on our ability to adapt to changing circumstances. The neuroendocrine response to stress is an excellent example of a plastic…”
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Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man by Kalafatakis, K., Russell, G. M., Harmer, C. J., Munafo, M. R., Marchant, N., Wilson, A., Brooks, J. C., Durant, C., Thakrar, J., Murphy, P., Thai, N. J., Lightman, S. L.

“…Glucocorticoids (GCs) are secreted in an ultradian, pulsatile pattern that emerges from delays in the feedforward-feedback interaction between the anterior…”
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The Importance of Biological Oscillators for Hypothalamic-Pituitary-Adrenal Activity and Tissue Glucocorticoid Response: Coordinating Stress and Neurobehavioural Adaptation by Russell, G. M., Kalafatakis, K., Lightman, S. L.

“…The hypothalamic‐pituitary‐adrenal (HPA) axis is critical for life. It has a circadian rhythm that anticipates the metabolic, immunoregulatory and cognitive…”
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New insights into corticosteroid-binding globulin and glucocorticoid delivery by Henley, D.E, Lightman, S.L

“…Abstract Corticosteroid-binding globulin (CBG) binds cortisol with high affinity and facilitates its transport in the blood. A recent discovery suggests that…”
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Continuous Free Cortisol Profiles – Circadian Rhythms in Healthy Men by Bhake, R, Kluckner, V, Stassen, H, Russell, G M, Leendertz, J, Stevens, K, Linthorst, A C E, Lightman, S L

“…The pituitary-adrenal axis had historically been considered a representative model for circadian rhythms. A recently developed portable collection device has…”
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Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice by Adekunbi, D. A., Li, X. F., Lass, G., Shetty, K., Adegoke, O. A., Yeo, S. H., Colledge, W. H., Lightman, S. L., O'Byrne, K. T.

“…The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is, however,…”
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Relative Importance of the Arcuate and Anteroventral Periventricular Kisspeptin Neurons in Control of Puberty and Reproductive Function in Female Rats by Hu, M. H, Li, X. F, McCausland, B, Li, S. Y, Gresham, R, Kinsey-Jones, J. S, Gardiner, J. V, Sam, A. H, Bloom, S. R, Poston, L, Lightman, S. L, Murphy, K. G, O'Byrne, K. T

“…Kisspeptin plays a critical role in pubertal timing and reproductive function. In rodents, kisspeptin perikarya within the hypothalamic arcuate (ARC) and…”
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Normalizing Eating Behavior Reduces Body Weight and Improves Gastrointestinal Hormonal Secretion in Obese Adolescents by Galhardo, J, Hunt, L. P, Lightman, S. L, Sabin, M. A, Bergh, C, Sodersten, P, Shield, J. P. H

“…Hypothesis: Retraining obese adolescents to eat more slowly will lead to beneficial changes in circulating concentrations of gastrointestinal satiety hormones…”
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Emotional sensitivity for motherhood: Late pregnancy is associated with enhanced accuracy to encode emotional faces by Pearson, R.M., Lightman, S.L., Evans, J.

“…Previous research suggests that female sex hormones can increase the sensitivity of women's emotion processing systems. The largest rises in sex hormone levels…”
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Syphilis and HIV: a dangerous combination by Lynn, W A, Lightman, S

“…HIV and syphilis affect similar patient groups and co-infection is common. All patients presenting with syphilis should be offered HIV testing and all…”
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Do Corticosteroids Damage the Brain? by Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., De Kloet, E. R., Lightman, S. L., Lupien, S. J., Roozendaal, B., Seckl, J. R.

“…Corticosteroids are an essential component of the body's homeostatic system. In common with other such systems, this implies that corticosteroid levels in…”
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Glucocorticoid Ultradian Rhythmicity Directs Cyclical Gene Pulsing of the Clock Gene Period 1 in Rat Hippocampus by Conway-Campbell, B. L ., Sarabdjitsingh, R. A., McKenna, M. A., Pooley, J. R., Kershaw, Y. M., Meijer, O. C., De Kloet, E. R., Lightman, S. L .

“…In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the…”
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The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats by Li, X. F, Hu, M. H, Hanley, B. P, Lin, Y. S, Poston, L, Lightman, S. L, O'Byrne, K. T

“…Obesity is the major risk factor for early puberty, but emerging evidence indicates other factors including psychosocial stress. One key brain region notable…”
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Suppression of the GnRH Pulse Generator by Neurokinin B Involves a κ-Opioid Receptor-Dependent Mechanism by Grachev, P, Li, X. F, Kinsey-Jones, J. S, di Domenico, A. L, Millar, R. P, Lightman, S. L, O'Byrne, K. T

“…Neurokinin B (NKB) and its receptor (NK3R) are coexpressed with kisspeptin, Dynorphin A (Dyn), and their receptors [G-protein-coupled receptor-54 (GPR54)] and…”
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Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery by Gibbison, B, Angelini, G.D., Lightman, S.L.

“…The hypothalamic-pituitary-adrenal (HPA) axis is a neuro-endocrine system that regulates circulating levels of glucocorticoid hormones. These hormones are…”
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Feasibility of salivary cortisol collection in patients and companions attending dementia diagnostic meetings in memory clinics by Pavlickova, H, Russell, A E, Lightman, S, McCabe, R

“…Receiving a diagnosis of dementia is life-changing for the individual and their companion. The aim of the study was to explore the feasibility of collecting…”
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Growth hormone secretion, fatigue and quality of life after childhood traumatic brain injury by Daskas, N, Sharples, P, Likeman, M, Lightman, S, Crowne, E C

“…Context Traumatic brain injury (TBI) is a recognised cause of hypopituitarism in adults but the prevalence after childhood TBI remains controversial. Objective…”
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Depressive symptoms in early pregnancy disrupt attentional processing of infant emotion by Pearson, R M, Cooper, R M, Penton-Voak, I S, Lightman, S L, Evans, J

“…Growing evidence suggests that perinatal depression is associated with disrupted mother-infant interactions and poor infant outcomes. Antenatal depression may…”
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Gonadal Steroid Replacement Reverses Gonadectomy-Induced Changes in the Corticosterone Pulse Profile and Stress-Induced Hypothalamic-Pituitary-Adrenal Axis Activity of Male and Female Rats by Seale, J. V., Wood, S. A., Atkinson, H. C., Harbuz, M. S., Lightman, S. L.

“…We investigated the effects of gonadal hormone replacement on the pulsatile parameters underlying basal circadian corticosterone secretion in castrated male…”
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Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17 by Lightman, S, Taylor, S R J, Bunce, C, Longhurst, H, Lynn, W, Moots, R, Stanford, M, Tomkins-Netzer, O, Yang, D, Calder, V L, Haskard, D O

“…To determine whether the addition of 26 weeks of subcutaneous peginterferon-α-2b could reduce the requirement for systemic corticosteroids and conventional…”
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