Search Results - "LIGEIRO, Dario"

HLA frequency distribution of the Portuguese bone marrow donor registry by Espada, Eduardo, Ligeiro, Dário, Trindade, Hélder, Lacerda, João F

“…The Portuguese donor Registry of CEDACE was the fifth largest bone marrow donor Registry of the WMDA as of 2019 and has yet to be thoroughly analyzed. We aimed…”
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The rare DRB104:08-DQ8 haplotype is the main HLA class II genetic driver and discriminative factor of Early-onset Type 1 diabetes in the Portuguese population by Caramalho, Iris, Matoso, Paula, Ligeiro, Dário, Paixão, Tiago, Sobral, Daniel, Fitas, Ana Laura, Limbert, Catarina, Demengeot, Jocelyne, Penha-Gonçalves, Carlos

“…Early-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen…”
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Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity by Ribeiro, Andreia Fiúza, Fitas, Ana Laura, Pires, Marcela Oliveira, Matoso, Paula, Ligeiro, Dário, Sobral, Daniel, Penha-Gonçalves, Carlos, Demengeot, Jocelyne, Caramalho, Íris, Limbert, Catarina

“…This study is aimed at comparing whole exome sequencing (WES) data with the clinical presentation in children with type 1 diabetes onset ≤ 5 years of age…”
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A case of fulminant Type 1 diabetes following anti-PD1 immunotherapy in a genetically susceptible patient by Araújo, Manuel, Ligeiro, Dário, Costa, Luís, Marques, Filipa, Trindade, Helder, Correia, José Manuel, Fonseca, Candida

“…Programmed cell death-1 protein (PD-1) is an immune checkpoint that has gained popularity in the treatment of several advanced cancers. Inhibiting this…”
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ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines by Videira, Paula A, Correia, Manuela, Malagolini, Nadia, Crespo, Hélio J, Ligeiro, Dário, Calais, Fernando M, Trindade, Helder, Dall'Olio, Fabio

“…The T antigen is a tumor-associated structure whose sialylated form (the sialyl-T antigen) involves the altered expression of sialyltransferases and has been…”
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IL-10 Overexpression Predisposes to Invasive Aspergillosis by Suppressing Antifungal Immunity by Cunha, Cristina, PhD, Gonçalves, Samuel M., BSc, Duarte-Oliveira, Cláudio, BSc, Leite, Luís, MD, Lagrou, Katrien, MD, PhD, Marques, António, MD, Lupiañez, Carmen B., MSc, Mesquita, Inês, MSc, Gaifem, Joana, MSc, Barbosa, Ana Margarida, MSc, Pinho Vaz, Carlos, MD, Branca, Rosa, MD, Campilho, Fernando, MD, Freitas, Fátima, MD, Ligeiro, Dário, BSc, Lass-Flörl, Cornelia, MD, Löffler, Jürgen, PhD, Jurado, Manuel, MD, Saraiva, Margarida, PhD, Kurzai, Oliver, MD, PhD, Rodrigues, Fernando, PhD, Castro, António G., PhD, Silvestre, Ricardo, PhD, Sainz, Juan, PhD, Maertens, Johan A., MD, PhD, Torrado, Egídio, PhD, Jacobsen, Ilse D., PhD, Lacerda, João F., MD, PhD, Campos, António, MD, Carvalho, Agostinho, PhD

“…We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results…”
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Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites by Rodrigues, Armanda Viana, Valerio-Bolas, Ana, Pires de Melo, Graça, Aires Pereira, Maria, Landeiro Raposo Pina Nunes, Telmo Renato, Ligeiro, Dario, Soares Pereira da Fonseca de Sampaio, Isabel Maria, Santos-Gomes, Gabriela

“…Research Areas: Life Sciences & Biomedicine L. infantum is the aetiological agent of zoonotic visceral leishmaniasis (ZVL), a disease that affects humans and…”
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B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer: Opportunities for Precision Medicine? by Ligeiro, Dário, Rao, Martin, Maia, Andreia, Castillo, Mireia, Beltran, Antonio, Maeurer, Markus

“…We review state-of-the-art in translational and clinical studies focusing on the tumor microenvironment (TME) with a focus on tumor-infiltrating B cells…”
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Understanding the Inguinal Sinus in Sheep (Ovis aries)-Morphology, Secretion, and Expression of Progesterone, Estrogens, and Prolactin Receptors by Alexandre-Pires, Graça, Martins, Catarina, Galvão, António M, Miranda, Margarida, Silva, Olga, Ligeiro, Dário, Nunes, Telmo, Ferreira-Dias, Graça

“…Post-parturient behavior of mammalian females is essential for early parent-offspring contact. After delivery, lambs need to ingest colostrum for obtaining the…”
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IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity by Silva, Susana L, Albuquerque, Adriana S, Matoso, Paula, Charmeteau-de-Muylder, Bénédicte, Cheynier, Rémi, Ligeiro, Dário, Abecasis, Miguel, Anjos, Rui, Barata, João T, Victorino, Rui M M, Sousa, Ana E

“…Naive CD4 T-cell maintenance is critical for immune competence. We investigated here the fine-tuning of homeostatic mechanisms of the naive compartment to…”
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Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects by Pimentel-Santos, Fernando M, Ligeiro, Dário, Matos, Mafalda, Mourão, Ana F, Costa, José, Santos, Helena, Barcelos, Anabela, Godinho, Fátima, Pinto, Patricia, Cruz, Margarida, Fonseca, João E, Guedes-Pinto, Henrique, Branco, Jaime C, Brown, Matthew A, Thomas, Gethin P

“…A number of genetic-association studies have identified genes contributing to ankylosing spondylitis (AS) susceptibility but such approaches provide little…”
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Efficacy of Bacille Calmette-Guérin Immunotherapy Predicted by Expression of Antigen-presenting Molecules and Chemokines by Videira, Paula A, Calais, Fernando M, Correia, Manuela, Ligeiro, Dário, Crespo, Hélio J, Calais, Fernando, Trindade, Hélder

“…Objectives To ascertain the role and prognostic value of antigen-presenting molecules and chemokines in the prophylactic effect of intravesical bacille…”
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Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran by M Xavier, Joana, Davatchi, Fereydoun, Abade, Olga, Shahram, Farhad, Francisco, Vânia, Abdollahi, Bahar Sadeghi, Trindade, Hélder, Nadji, Abdolhadi, Shafiee, Niloofar Mojarad, Ghaderibarmi, Fahmida, Ligeiro, Dário, Oliveira, Sofia A

“…© 2015 Xavier et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License…”
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Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment by Badura, Robert, Foxall, Russell B, Ligeiro, Dario, Rocha, Miguel, Godinho-Santos, Ana, Trombetta, Amelia C, Sousa, Ana E

“…HIV-1 infection induces B cell defects, not fully recovered upon antiretroviral therapy (ART). Acute infection and the early start of ART provide unique…”
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Naive and stem cell memory T cell subset recovery reveals opposing reconstitution patterns in CD4 and CD8 T cells in chronic graft vs. host disease by Godinho A.V. D. Soares, Maria, Azevedo, Rita, Ferreira, Ines, Bucar, Sara, Ribeiro, Ana C., Vieira, Ana, Pereira, Paulo N G, Ribeiro, Ruy Miguel, Ligeiro, Dario, Alho, Ana Cristina, Sampaio Soares, António, Camacho, Nádia, Martins, Carlos, Lourenço, Fernanda, Moreno, Raul, Ritz, Jerome, Lacerda, João

“…Copyright © 2019 Soares, Azevedo, Ferreira, Bucar, Ribeiro, Vieira, Pereira, Ribeiro, Ligeiro, Alho, Soares, Camacho, Martins, Lourenço, Moreno, Ritz and…”
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The phagocytic capacity and immunological potency of human dendritic cells is improved by [alpha]2,6-sialic acid deficiency by Cabral, M Guadalupe, Silva, Zélia, Ligeiro, Dário, Seixas, Elsa, Crespo, Hélio, Carrascal, Mylène A, Silva, Mariana, Piteira, Ana R, Paixao, Paulo, Lau, Joseph T, Videira, Paula A

“…Summary Dendritic cells (DCs) play an essential role in immunity against bacteria by phagocytosis and by eliciting adaptive immune responses. Previously, we…”
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Screening of congenital cytomegalovirus infection by real-time PCR in urine pools by Paixão, Paulo, Almeida, Sofia, Videira, Paula A., Ligeiro, Dário, Marques, Teresa

“…Human cytomegalovirus (HCMV) is the most frequent cause of congenital infection. Despite the fact that 5–17% of asymptomatic infected babies will develop late…”
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Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation by Albuquerque, Adriana S, Marques, José G, Silva, Susana L, Ligeiro, Dario, Devlin, Blythe H, Dutrieux, Jacques, Cheynier, Rémi, Pignata, Claudio, Victorino, Rui M M, Markert, M Louise, Sousa, Ana E

“…Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a…”
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Morphological aspects and expression of estrogen and progesterone receptors in the interdigital sinus in cyclic ewes by Alexandre-Pires, Graça, Martins, Catarina, Miguel Galvão, António, Correia, Miguel, Ramilo, David, Quaresma, Mário, Ligeiro, Dário, Nunes, Telmo, Manuel Caldeira, Rui, Ferreira-Dias, Graça

“…ABSTRACT Many species that belong to Artiodactyls order show an interdigital sinus (IS), as it occurs in sheep, in all four extremities. These are considered…”
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Human dendritic cells contain cell surface sialyltransferase activity by Cabral, M. Guadalupe, Piteira, A. Rita, Silva, Zélia, Ligeiro, Dário, Brossmer, Reinhard, Videira, Paula A

“…Abstract Human monocyte-derived dendritic cells (mo-DCs) express highly sialylated structures, with recognized but poorly understood function in maturation,…”
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