Search Results - "LIEU, Christopher"

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection by Patel, Swati G, Karlitz, Jordan J, Yen, Timothy, Lieu, Christopher H, Boland, C Richard

“…The incidence of early-onset colorectal cnacer-ie, colorectal cancer diagnosed in patients under the age of 50 years- has been increasing around the world…”
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Podcast article: Biomarker testing in colorectal cancer by Lieu, Christopher H

“…Christopher Lieu, co-director of gastrointestinal medical oncology and the associate director for clinical research at the University of Colorado Cancer Center…”
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Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer by Lieu, Christopher H, Golemis, Erica A, Serebriiskii, Ilya G, Newberg, Justin, Hemmerich, Amanda, Connelly, Caitlin, Messersmith, Wells A, Eng, Cathy, Eckhardt, S Gail, Frampton, Garrett, Cooke, Matthew, Meyer, Joshua E

“…The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor…”
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Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis by LIEU, Christopher, HEYMACH, John, OVERMAN, Michael, TRAN, Hai, KOPETZ, Scott

“…Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival, angiogenesis, and wound healing. Compelling evidence for…”
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Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer by Tran, Ben, Kopetz, Scott, Tie, Jeanne, Gibbs, Peter, Jiang, Zhi‐Qin, Lieu, Christopher H., Agarwal, Atin, Maru, Dipen M., Sieber, Oliver, Desai, Jayesh

“…BACKGROUND: It is hypothesized that BRAF mutant cancers represent a discrete subset of metastatic colorectal cancer (CRC) defined by poorer survival. This…”
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A comprehensive framework for early-onset colorectal cancer research by Eng, Cathy, Jácome, Alexandre A, Agarwal, Rajiv, Hayat, Muhammad Hashim, Byndloss, Mariana X, Holowatyj, Andreana N, Bailey, Christina, Lieu, Christopher H

“…Sporadic colorectal cancer has traditionally been viewed as a malignancy of older individuals. However, as the global prevalence of the disease diagnosed in…”
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Gut instinct: a call to study the biology of early-onset colorectal cancer disparities by Holowatyj, Andreana N., Perea, Jose, Lieu, Christopher H.

“…Colorectal cancer (CRC) incidence among individuals age younger than 50 years continues to rise with etiologies unknown. Synchronously, early-onset CRC…”
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ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper by Dasari, Arvind, Morris, Van K., Allegra, Carmen J., Atreya, Chloe, Benson, Al B., Boland, Patrick, Chung, Ki, Copur, Mehmet S., Corcoran, Ryan B., Deming, Dustin A., Dwyer, Andrea, Diehn, Maximilian, Eng, Cathy, George, Thomas J., Gollub, Marc J., Goodwin, Rachel A., Hamilton, Stanley R., Hechtman, Jaclyn F., Hochster, Howard, Hong, Theodore S., Innocenti, Federico, Iqbal, Atif, Jacobs, Samuel A., Kennecke, Hagen F., Lee, James J., Lieu, Christopher H., Lenz, Heinz-Josef, Lindwasser, O. Wolf, Montagut, Clara, Odisio, Bruno, Ou, Fang-Shu, Porter, Laura, Raghav, Kanwal, Schrag, Deborah, Scott, Aaron J., Shi, Qian, Strickler, John H., Venook, Alan, Yaeger, Rona, Yothers, Greg, You, Y. Nancy, Zell, Jason A., Kopetz, Scott

“…An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this…”
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Treatment of Metastatic Colorectal Cancer: ASCO Guideline by Morris, Van K, Kennedy, Erin B, Baxter, Nancy N, Benson, 3rd, Al B, Cercek, Andrea, Cho, May, Ciombor, Kristen K, Cremolini, Chiara, Davis, Anjee, Deming, Dustin A, Fakih, Marwan G, Gholami, Sepideh, Hong, Theodore S, Jaiyesimi, Ishmael, Klute, Kelsey, Lieu, Christopher, Sanoff, Hanna, Strickler, John H, White, Sarah, Willis, Jason A, Eng, Cathy

“…To develop recommendations for treatment of patients with metastatic colorectal cancer (mCRC). ASCO convened an Expert Panel to conduct a systematic review of…”
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Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update by Baxter, Nancy N, Kennedy, Erin B, Bergsland, Emily, Berlin, Jordan, George, Thomas J, Gill, Sharlene, Gold, Philip J, Hantel, Alex, Jones, Lee, Lieu, Christopher, Mahmoud, Najjia, Morris, Arden M, Ruiz-Garcia, Erika, You, Y Nancy, Meyerhardt, Jeffrey A

“…To develop recommendations for adjuvant therapy for patients with resected stage II colon cancer. ASCO convened an Expert Panel to conduct a systematic review…”
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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients by Serebriiskii, Ilya G., Connelly, Caitlin, Frampton, Garrett, Newberg, Justin, Cooke, Matthew, Miller, Vince, Ali, Siraj, Ross, Jeffrey S., Handorf, Elizabeth, Arora, Sanjeevani, Lieu, Christopher, Golemis, Erica A., Meyer, Joshua E.

“…Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within…”
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The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer by Lieu, Christopher H, Tran, Hai, Jiang, Zhi-Qin, Mao, Muling, Overman, Michael J, Lin, E, Eng, Cathy, Morris, Jeffrey, Ellis, Lee, Heymach, John V, Kopetz, Scott

“…Circulating angiogenic factors are altered in patients with mCRC receiving bevacizumab. Evaluation of alterations in levels of VEGF ligands may provide…”
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Targeting the WNT Signaling Pathway in Cancer Therapeutics by Tai, David, Wells, Keith, Arcaroli, John, Vanderbilt, Chad, Aisner, Dara L., Messersmith, Wells A., Lieu, Christopher H.

“…The WNT signaling cascade is integral in numerous biological processes including embryonic development, cell cycle regulation, inflammation, and cancer…”
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Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406) by Kopetz, Scott, Guthrie, Katherine A, Morris, Van K, Lenz, Heinz-Josef, Magliocco, Anthony M, Maru, Dipen, Yan, Yibing, Lanman, Richard, Manyam, Ganiraju, Hong, David S, Sorokin, Alexey, Atreya, Chloe E, Diaz, Luis A, Allegra, Carmen, Raghav, Kanwal P, Wang, Stephen E, Lieu, Christopher H, McDonough, Shannon L, Philip, Philip A, Hochster, Howard S

“…mutations are rarely associated with objective responses to the BRAF inhibitor vemurafenib in patients with metastatic colorectal cancer (CRC). Blockade of by…”
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Association of age with survival in patients with metastatic colorectal cancer: analysis from the ARCAD Clinical Trials Program by Lieu, Christopher H, Renfro, Lindsay A, de Gramont, Aimery, Meyers, Jeffrey P, Maughan, Timothy S, Seymour, Matthew T, Saltz, Leonard, Goldberg, Richard M, Sargent, Daniel J, Eckhardt, S Gail, Eng, Cathy

“…This study addressed whether age is prognostic for overall survival (OS) or progression-free survival (PFS) in patients with metastatic colorectal cancer…”
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Biomarker Testing Trends in Patients With Metastatic Colorectal Cancer Who Live in Rural Areas and Urban Clusters in the US by Lewis, Mark A, Stansfield, Lindsay, Kelton, John M, Lieu, Christopher H

“…Abstract Background There is a paucity of data on biomarker testing rates in rural populations with metastatic colorectal cancer (mCRC). To assess biomarker…”
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Current status and future of targeted peptide receptor radionuclide positron emission tomography imaging and therapy of gastroenteropancreatic-neuroendocrine tumors by Grey, Neil, Silosky, Michael, Lieu, Christopher H, Chin, Bennett B

“…Theranostics is the highly targeted molecular imaging and therapy of tumors. Targeted peptide receptor radionuclide therapy has taken the lead in demonstrating…”
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Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin by Siddiqui, Almas, Bhaumik, Dipa, Chinta, Shankar J, Rane, Anand, Rajagopalan, Subramanian, Lieu, Christopher A, Lithgow, Gordon J, Andersen, Julie K

“…Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial membrane proteins, initiating…”
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Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology by Sepulveda, Antonia R, Hamilton, Stanley R, Allegra, Carmen J, Grody, Wayne, Cushman-Vokoun, Allison M, Funkhouser, William K, Kopetz, Scott E, Lieu, Christopher, Lindor, Noralane M, Minsky, Bruce D, Monzon, Federico A, Sargent, Daniel J, Singh, Veena M, Willis, Joseph, Clark, Jennifer, Colasacco, Carol, Rumble, R Bryan, Temple-Smolkin, Robyn, Ventura, Christina B, Nowak, Jan A

“…Purpose Molecular testing of colorectal cancers (CRCs) to improve patient care and outcomes of targeted and conventional therapies has been the center of many…”
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Age-related behavioral phenotype of an astrocytic monoamine oxidase-B transgenic mouse model of Parkinson's disease by Lieu, Christopher A, Chinta, Shankar J, Rane, Anand, Andersen, Julie K

“…We have previously shown that increases in astrocytic monoamine oxidase-B (MAO-B) expression, mimicking that which occurs with aging and in neurodegenerative…”
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