Search Results - "LIENHARD, G. E"

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans by BJÖRNHOLM, M, HE, A. R, ATTERSAND, A, LAKE, S, LIU, S. C. H, LIENHARD, G. E, TAYLOR, S, ARNER, P, ZIERATH, J. R

“…Insulin receptor substrate (IRS) proteins play important roles in insulin action and pancreatic beta-cell function. At least four mammalian IRS molecules have…”
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The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp by Kuhné, M R, Pawson, T, Lienhard, G E, Feng, G S

“…The insulin receptor substrate 1 (IRS1) is a protein that is rapidly phosphorylated on tyrosine by the activated insulin receptor. Syp is a recently…”
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Immuno-Localization of the Insulin Regulatable Glucose Transporter in Brown Adipose Tissue of the Rat by Slot, Jan W., Geuze, Hans J., Gigengack, Sander, Lienhard, Gustav E., James, David E.

“…Antibodies specific for the insulin-regulatable glucose transporter (GLUT 4) were used to immunolocalize this protein in brown adipose tissue from basal- and…”
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Analysis of TBC1D4 in patients with severe insulin resistance by Dash, S, Langenberg, C, Fawcett, K. A, Semple, R. K, Romeo, S, Sharp, S, Sano, H, Lienhard, G. E, Rochford, J. J, Howlett, T, Massoud, A. F, Hindmarsh, P, Howell, S. J, Wilkinson, R. J, Lyssenko, V, Groop, L, Baroni, M. G, Barroso, I, Wareham, N. J, O' Rahilly, S, Savage, D. B

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Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes by CORLEY CAIN, C, TRIMBLE, W. S, LIENHARD, G. E

“…Existing data support the hypothesis that insulin triggers the exocytosis of small vesicles containing the GluT4 isoform of the glucose transporter. The data…”
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Translocation of the Glucose Transporter GLUT4 in Cardiac Myocytes of the Rat by SLOT, J. W, GEUZE, H. J, GIGENGACK, S, JAMES, D. E, LIENHARD, G. E

“…The insulin-regulated glucose transporter GLUT4 was immunolocalized in rat cardiac muscle under conditions of basal and stimulated glucose uptake, achieved by…”
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Insulin stimulates cell surface aminopeptidase activity toward vasopressin in adipocytes by Herbst, J J, Ross, S A, Scott, H M, Bobin, S A, Morris, N J, Lienhard, G E, Keller, S R

“…We previously discovered that insulin stimulates the marked translocation of a novel membrane aminopeptidase, designated vp165 for vesicle protein of 165 kDa,…”
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Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane by MASTICK, C. C, AEBERSOLD, R, LIENHARD, G. E

“…GLUT4-enriched vesicles from fat and muscle cells contain a major protein of 165 kDa. In the present study we have prepared GLUT4 vesicles from a large number…”
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The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase by Lavan, B.E, Lienhard, G.E

“…Insulin stimulates the tyrosine phosphorylation of a 60-kDa protein (pp60) in rat adipocytes. After insulin treatment of these cells, pp60, as well as the…”
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Common Elements in Interleukin 4 and Insulin Signaling Pathways in Factor- Dependent Hematopoietic Cells by Wang, Ling-Mei, Keegan, Achsah D., Li, Weiqun, Lienhard, Gustav E., Pacini, Stefania, Gutkind, J. Silvio, Myers, Martin G., Sun, Xiao-Jian, White, Morris F., Aaronson, Stuart A., Paul, William E., Pierce, Jacalyn H.

“…Interleukin 4 (IL-4), insulin, and insulin-like growth factor I (IGF-I) efficiently induced DNA synthesis in the IL-3-dependent murine myeloid cell lines…”
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Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes by CALDERHEAD, D. M, KITAGAWA, K, TANNER, L. I, HOLMAN, G. D, LIENHARD, G. E

“…The amounts of the brain type and muscle type glucose transporters (designated Glut 1 and 4, respectively) in 3T3-L1 adipocytes have been determined by…”
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Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization by Tanner, L I, Lienhard, G E

“…Incubation of 3T3-L1 adipocytes with insulin at 37 degrees C resulted in a 2-fold increase in specific binding of transferrin to cell-surface receptors, as…”
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The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains by LAVAN, B. E, KUHNE, M. R, GARNER, C. W, ANDERSON, D, REEDIJK, M, PAWSON, T, LIENHARD, G. E

“…The interactions of the phosphotyrosine (Tyr(P))-containing proteins in basal and insulin-stimulated 3T3-L1 adipocytes with src homology 2 (SH2) domains from…”
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Regulation of the expression of pp160, a putative insulin receptor signal protein, by insulin, dexamethasone, and 1-methyl-3-isobutylxanthine in 3T3-L1 adipocytes by RICE, K. M, LIENHARD, G. E, GARNER, C. W

“…pp160, a cytosolic protein with Mr of approximately 160,000, is phosphorylated on tyrosine in response to insulin and is considered to be involved in signaling…”
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Dexamethasone causes translocation of glucose transporters from the plasma membrane to an intracellular site in human fibroblasts by Horner, H C, Munck, A, Lienhard, G E

“…To investigate the mechanism by which glucocorticoids inhibit glucose transport in peripheral tissues, we have used a monoclonal antibody directed against the…”
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Sequence and Structure of a Human Glucose Transporter by Mueckler, Mike, Caruso, Carla, Baldwin, Stephen A., Panico, Maria, Blench, Ian, Morris, Howard R., Allard, W. Jeffrey, Lienhard, Gustav E., Lodish, Harvey F.

“…The amino acid sequence of the glucose transport protein from human HepG2 hepatoma cells was deduced from analysis of a complementary DNA clone. Structural…”
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Labeling of glucose transporters at the cell surface in 3T3-L1 adipocytes. Evidence for both translocation and a second mechanism in the insulin stimulation of transport by Calderhead, D M, Lienhard, G E

“…In order to determine whether translocation of intracellular glucose transporters to the plasma membrane upon insulin stimulation accounts entirely for the…”
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Localization of Transferrin Receptors and Insulin-like Growth Factor II Receptors in Vesicles from 3T3-L1 Adipocytes That Contain Intracellular Glucose Transporters by Tanner, Laura I., Lienhard, Gustav E.

“…Transferrin receptors in detergent extracts of subcellular membrane fractions prepared from 3T3-L1 adipocytes were measured by a binding assay. There was a…”
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The glucose transporter GluT4 and secretory carrier membrane proteins (SCAMPs) colocalize in rat adipocytes and partially segregate during insulin stimulation by Laurie, S.M., Cain, C.C., Lienhard, G.E., Castle, J.D.

“…Secretory carrier membrane proteins (SCAMPs) mark the recycling system for the insulin-responsive glucose transporter, GluT4, in rat adipocytes. Anti-GluT4 and…”
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Insulin-Induced Translocation of Glucose Transporters from Post-Golgi Compartments to the Plasma Membrane of 3T3-L1 Adipocytes by Blok, John, Gibbs, E. Michael, Lienhard, Gustav E., Slot, J. W., Geuze, Hans J.

“…A semiquantitative method using immunocytochemistry on ultrathin cryosections and the protein A-gold technique was performed to study the effect of insulin on…”
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