Search Results - "LIENARD, Danielle"

Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy by Seremet, Teofila, Jansen, Yanina, Planken, Simon, Njimi, Hassan, Delaunoy, Mélanie, El Housni, Hakim, Awada, Gil, Schwarze, Julia Katharina, Keyaerts, Marleen, Everaert, Hendrik, Lienard, Danielle, Del Marmol, Véronique, Heimann, Pierre, Neyns, Bart

“…Treatment with anti-PD1 monoclonal antibodies improves the survival of metastatic melanoma patients but only a subgroup of patients benefits from durable…”
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Pretreatment Levels of Peripheral Neutrophils and Leukocytes As Independent Predictors of Overall Survival in Patients With American Joint Committee on Cancer Stage IV Melanoma: Results of the EORTC 18951 Biochemotherapy Trial by SCHMIDT, Henrik, SUCIU, Stefan, PUNT, Cornelis J. A, GORE, Martin, KRUIT, Wim, PATEL, Poulam, LIENARD, Danielle, VAN DER MAASE, Hans, EGGERMONT, Alexander M. M, KEILHOLZ, Ulrich

“…An elevated count of blood neutrophils and monocytes recently was shown independently to predict short survival in patients with stage IV melanoma undergoing…”
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Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients by Seremet, Teofila, Koch, Alexander, Jansen, Yanina, Schreuer, Max, Wilgenhof, Sofie, Del Marmol, Véronique, Liènard, Danielle, Thielemans, Kris, Schats, Kelly, Kockx, Mark, Van Criekinge, Wim, Coulie, Pierre G, De Meyer, Tim, van Baren, Nicolas, Neyns, Bart

“…Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10-15 % of patients. A tumor signature that…”
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Dacarbazine, Cisplatin, and Interferon-Alfa-2b With or Without Interleukin-2 in Metastatic Melanoma: A Randomized Phase III Trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group by KEILHOLZ, Ulrich, PUNT, Cornelis J. A, VELU, Thierry, NEGRIER, Sylvie, KLEEBERG, Ulrich, LEHMAN, Frederic, SUCIU, Stefan, EGGERMONT, Alexander M. M, GORE, Martin, KRUIT, Wim, PATEL, Poulam, LIENARD, Danielle, THOMAS, Jose, PROEBSTLE, Thomas M, SCHMITTEL, Alexander, SCHADENDORF, Dirk

“…Based on phase II trial results, chemoimmunotherapy combinations have become the preferred treatment for patients with metastatic melanoma in many…”
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Long-Term Protective Effect of Mature DC-LAMP+ Dendritic Cell Accumulation in Sentinel Lymph Nodes Containing Micrometastatic Melanoma by ELLIOTT, Bruce, SCOLYER, Richard A, TESTORI, Alessandro, EGGERMONT, Alexander, MACKIE, Rona, ROBERT, Caroline, COOK, Martin, THOMPSON, John F, ANGEVIN, Eric, SPATZ, Alain, SUCIU, Stefan, LEBECQUE, Serge, RIMOLDI, Donata, GUGERLI, Oliver, MUSAT, Elena, SHARMA, Raghwa N, LIENARD, Danielle, KEILHOLZ, Ulrich

“…Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph nodes (SLN) draining regressing melanomas, we found that the…”
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Discrepancy between ELISPOT IFN-γ Secretion and Binding of A2/peptide Multimers to TCR Reveals Interclonal Dissociation of CTL Effector Function from TCR-peptide/MHC Complexes Half-Life by Rubio-Godoy, Verena, Dutoit, Valerie, Rimoldi, Donata, Lienard, Danielle, Lejeune, Ferdy, Speiser, Daniel, Guillaume, Philippe, Cerottini, Jean-Charles, Romero, Pedro, Valmori, Danila

“…Activation of CD8+cytolytic T lymphocytes (CTLs) by antigen is triggered by the interaction of clonotypic αβ T cell receptors (TCRs) with antigenic peptides…”
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Pattern and clinical significance of cancer‐testis gene expression in head and neck squamous cell carcinoma by Cuffel, Cyril, Rivals, Jean‐Paul, Zaugg, Yannick, Salvi, Suzanne, Seelentag, Walter, Speiser, Daniel E., Liénard, Danielle, Monnier, Philippe, Romero, Pedro, Bron, Luc, Rimoldi, Donata

“…Cancer‐testis (CT) antigens comprise families of tumor‐associated antigens that are immunogenic in patients with various cancers. Their restricted expression…”
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Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance by ZIPPELIUS, Alfred, BATARD, Pascal, RUFER, Nathalie, LUBENOW, Norbert, SPEISER, Daniel, CEROTTINI, Jean-Charles, ROMERO, Pedro, PITTET, Mikaël J, RUBIO-GODOY, Verena, BIOLEY, Gilles, LIENARD, Danielle, LEJEUNE, Ferdy, RIMOLDI, Donata, GUILLAUME, Philippe, MEIDENBAUER, Norbert, MACKENSEN, Andreas

“…Although tumor-specific CD8 T-cell responses often develop in cancer patients, they rarely result in tumor eradication. We aimed at studying directly the…”
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Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma by Wilgenhof, Sofie, Du Four, Stephanie, Vandenbroucke, Frederik, Everaert, Hendrik, Salmon, Isabelle, Liénard, Danielle, Marmol, Véronique Del, Neyns, Bart

“…Ipilimumab, a CTLA-4-blocking monoclonal antibody, improved the overall survival (OS) of advanced melanoma patients treated in prospective clinical trials. We…”
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Efficient Simultaneous Presentation of NY-ESO-1/LAGE-1 Primary and Nonprimary Open Reading Frame-Derived CTL Epitopes in Melanoma by Rimoldi, Donata, Rubio-Godoy, Verena, Dutoit, Valerie, Lienard, Danielle, Salvi, Suzanne, Guillaume, Philippe, Speiser, Daniel, Stockert, Elisabeth, Spagnoli, Giulio, Servis, Catherine, Cerottini, Jean-Charles, Lejeune, Ferdy, Romero, Pedro, Valmori, Danila

“…Recent studies have shown that CTL epitopes derived from tumor-associated Ags can be encoded by both primary and nonprimary open reading frames (ORF). In this…”
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The Role of Line-Field Confocal Optical Coherence Tomography in Detecting Extramammary Paget Disease Recurrences: A Pilot Diagnostic Study by Diet, Gwendoline, Lenoir, Clément, Fontaine, Margot, Boussingault, Lucas, Orte Cano, Carmen, Mtimet, Lyna, Liénard, Danielle, Sanak, Dilara, Moulart, Florine, Bernardi, Dana, Trepant, Anne-Laure, Perez-Anker, Javiera, Puig, Susana, Malvehy, Josep, Cinotti, Elisa, Tognetti, Linda, Rubegni, Pietro, Perrot, Jean-Luc, Marmol, Véronique Del, Suppa, Mariano

“…Extramammary Paget disease (EMPD) is an uncommon adenocarcinoma of apocrine gland-rich areas, presenting significant diagnostic challenges due to its…”
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Tumoral and Immunologic Response After Vaccination of Melanoma Patients With an ALVAC Virus Encoding MAGE Antigens Recognized by T Cells by VAN BAREN, Nicolas, BONNET, Marie-Claude, ESCUDIER, Bernard, NEGRIER, Sylvie, DIETRICH, Pierre-Yves, MARANINCHI, Dominique, OSANTO, Susanne, MEYER, Ralf G, RITTER, Gerd, MOINGEON, Philippe, TARTAGLIA, Jim, VAN DER BRUGGEN, Pierre, DRENO, Brigitte, COULIE, Pierre G, BOON, Thierry, KHAMMARI, Amir, DORVAL, Thierry, PIPERNO-NEUMANN, Sophie, LIENARD, Danielle, SPEISER, Daniel, MARCHAND, Marie, BRICHARD, Vincent G

“…To evaluate the toxicity, antitumoral effectiveness, and immunogenicity of repeated vaccinations with ALVAC miniMAGE-1/3, a recombinant canarypox virus…”
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A Novel Approach to Characterize Clonality and Differentiation of Human Melanoma-Specific T Cell Responses: Spontaneous Priming and Efficient Boosting by Vaccination by Speiser, Daniel E, Baumgaertner, Petra, Barbey, Catherine, Rubio-Godoy, Verena, Moulin, Alexandre, Corthesy, Patricia, Devevre, Estelle, Dietrich, Pierre-Yves, Rimoldi, Donata, Lienard, Danielle, Cerottini, Jean-Charles, Romero, Pedro, Rufer, Nathalie

“…Despite major progress in T lymphocyte analysis in melanoma patients, TCR repertoire selection and kinetics in response to tumor Ags remain largely unexplored…”
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Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues by Valmori, Danila, Fonteneau, Jean-Francois, Lizana, Concepcion Maranon, Gervois, Nadine, Lienard, Danielle, Rimoldi, Donata, Jongeneel, Victor, Jotereau, Francine, Cerottini, Jean-Charles, Romero, Pedro

“…The Melan-A/MART-1 gene, which is expressed by normal melanocytes as well as by most fresh melanoma samples and melanoma cell lines, codes for Ags recognized…”
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Objective responses can be obtained by CTLA-4 inhibition in metastatic melanoma after BRAF inhibitor failure by Schreuer, Max S, Chevolet, Ines L, Jansen, Yanina J, Seremet, Teofila C, Wilgenhof, Sofie, Liénard, Danielle, Del Marmol, Veronique, Neyns, Bart

“…The aim of this study was to determine the activity of ipilimumab (ipi)-based therapy after treatment failure with a BRAF inhibitor (BRAFi). Sixty-four…”
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Lack of BRAF mutations in uveal melanoma by RIMOLDI, Donata, SALVI, Suzanne, LIENARD, Danielle, LEJEUNE, Ferdy J, SPEISER, Daniel, ZOGRAFOS, Leonidas, CEROTTINI, Jean-Charles

“…RAF proteins are serine/threonine kinases that mediate cellular responses to growth signals by activating the mitogen-activated protein kinase pathway…”
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Monoclonal Anti-MAGE-3 CTL Responses in Melanoma Patients Displaying Tumor Regression after Vaccination with a Recombinant Canarypox Virus by Karanikas, Vaios, Lurquin, Christophe, Colau, Didier, van Baren, Nicolas, De Smet, Charles, Lethe, Bernard, Connerotte, Thierry, Corbiere, Veronique, Demoitie, Marie-Ange, Lienard, Danielle, Dreno, Brigitte, Velu, Thierry, Boon, Thierry, Coulie, Pierre G

“…We have analyzed the T cell responses of HLA-A1 metastatic melanoma patients with detectable disease, following vaccination with a recombinant ALVAC virus,…”
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Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma by Romero, Pedro, Valmori, Danila, Pittet, Mikael J., Zippelius, Alfred, Rimoldi, Donata, Lévy, Frederic, Dutoit, Valérie, Ayyoub, Maha, Rubio-Godoy, Verena, Michielin, Olivier, Guillaume, Philippe, Batard, Pascal, Luescher, Immanuel F., Lejeune, Ferdy, Liénard, Danielle, Rufer, Nathalie, Dietrich, Pierre-Yves, Speiser, Daniel E., Cerottini, Jean-Charles

“…Some cancer patients mount spontaneous T‐ and B‐cell responses against their tumor cells. Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4…”
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Ex vivo detectable human CD8 T-Cell responses to cancer-testis antigens by BAUMGAERTNER, Petra, RUFER, Nathalie, DEVEVRE, Estelle, DERRE, Laurent, RIMOLDI, Donata, GELDHOF, C Hristine, VOELTER, Verena, LIENARD, Danielle, ROMERO, Pedro, SPEISER, Daniel E

“…Clinical trials have shown that strong tumor antigen-specific CD8 T-cell responses are difficult to induce but can be achieved for T-cells specific for…”
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Anaphylaxis-like reaction to anti-BRAF inhibitor dabrafenib confirmed by drug provocation test by Seremet, Teofila, Haccuria, Amaryllis, Lienard, Danielle, Del Marmol, Véronique, Neyns, Bart

“…The combination of BRAF and MEK inhibitors is a standard therapeutic option for patients with metastatic melanoma with BRAF-mutated tumors. This type of…”
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