Search Results - "LIEN, Egil"

Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity by Orning, Pontus, Lien, Egil

“…Caspase‐8 is an apical caspase involved in the programmed form of cell death called apoptosis that is critically important for mammalian development and…”
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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death by Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A, Berger, Scott B, Gough, Peter J, Bertin, John, Proulx, Megan M, Goguen, Jon D, Kayagaki, Nobuhiko, Fitzgerald, Katherine A, Lien, Egil

“…Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via…”
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RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages by Tao, Liang, Yi, Yuguo, Chen, Yuxin, Zhang, Haibing, Orning, Pontus, Lien, Egil, Jie, Jiapeng, Zhang, Weigao, Xu, Qian, Li, Yang, Ding, Zhao, Wu, Chao, Ding, Qiurong, Wang, Junsong, Zhang, Jianfa, Weng, Dan

“…Hepatocyte cell death and liver inflammation have been well recognized as central characteristics of nonalcoholic steatohepatitis (NASH), however, the…”
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Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants by Marty-Roix, Robyn, Vladimer, Gregory I., Pouliot, Kimberly, Weng, Dan, Buglione-Corbett, Rachel, West, Kim, MacMicking, John D., Chee, Jonathan D., Wang, Shixia, Lu, Shan, Lien, Egil

“…Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules…”
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Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol‐Associated Liver Injury by Choudhury, Asmita, Bullock, Daniel, Lim, Arlene, Argemi, Josepmaria, Orning, Pontus, Lien, Egil, Bataller, Ramon, Mandrekar, Pranoti

“…Background Activation of NLRP3 in liver macrophages contributes to alcohol‐associated liver disease (ALD). Molecular chaperone heat shock protein (HSP) 90…”
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MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection by Lei, Xuqiu, Chen, Yongzhi, Lien, Egil, Fitzgerald, Katherine A

“…Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and…”
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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury by Sandanger, Øystein, Ranheim, Trine, Vinge, Leif Erik, Bliksøen, Marte, Alfsnes, Katrine, Finsen, Alexandra V, Dahl, Christen P, Askevold, Erik T, Florholmen, Geir, Christensen, Geir, Fitzgerald, Katherine A, Lien, Egil, Valen, Guro, Espevik, Terje, Aukrust, Pål, Yndestad, Arne

“…Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory…”
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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death by Weng, Dan, Marty-Roix, Robyn, Ganesan, Sandhya, Proulx, Megan K., Vladimer, Gregory I., Kaiser, William J., Mocarski, Edward S., Pouliot, Kimberly, Chan, Francis Ka-Ming, Kelliher, Michelle A., Harris, Phillip A., Bertin, John, Gough, Peter J., Shayakhmetov, Dmitry M., Goguen, Jon D., Fitzgerald, Katherine A., Silverman, Neal, Lien, Egil

“…A number of pathogens cause host cell death upon infection, and Yersinia pestis , infamous for its role in large pandemics such as the “Black Death” in…”
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The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation by Ratner, Dmitry, Orning, M Pontus A, Proulx, Megan K, Wang, Donghai, Gavrilin, Mikhail A, Wewers, Mark D, Alnemri, Emad S, Johnson, Peter F, Lee, Bettina, Mecsas, Joan, Kayagaki, Nobuhiko, Goguen, Jon D, Lien, Egil

“…Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects…”
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NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction by Sokolova, Marina, Sahraoui, Afaf, Høyem, Merete, Øgaard, Jonas, Lien, Egil, Aukrust, Pål, Yndestad, Arne, Ranheim, Trine, Scholz, Hanne

“…Inflammasomes are multiprotein inflammatory platforms that induce caspase-1 activation and subsequently interleukin (IL)-1β and IL-18 processing. The NLRP3…”
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Caspase-8 mediates inflammation and disease in rodent malaria by Pereira, Larissa M. N., Assis, Patrícia A., de Araújo, Natalia M., Durso, Danielle F., Junqueira, Caroline, Ataíde, Marco Antônio, Pereira, Dhelio B., Lien, Egil, Fitzgerald, Katherine A., Zamboni, Dario S., Golenbock, Douglas T., Gazzinelli, Ricardo T.

“…Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we…”
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MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation by Meng, Jianmin, Lien, Egil, Golenbock, Douglas T.

“…Lipopolysaccharide (LPS) activates innate immune responses through TLR4·MD-2. LPS binds to the MD-2 hydrophobic pocket and bridges the dimerization of two…”
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The NLRP12 Inflammasome Recognizes Yersinia pestis by Vladimer, Gregory I., Weng, Dan, Paquette, Sara W. Montminy, Vanaja, Sivapriya Kailasan, Rathinam, Vijay A.K., Aune, Marie Hjelmseth, Conlon, Joseph E., Burbage, Joseph J., Proulx, Megan K., Liu, Qin, Reed, George, Mecsas, Joan C., Iwakura, Yoichiro, Bertin, John, Goguen, Jon D., Fitzgerald, Katherine A., Lien, Egil

“…Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through…”
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Bacterial secretion systems and regulation of inflammasome activation by Ratner, Dmitry, Orning, M. Pontus A., Lien, Egil

“…Innate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they…”
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A Role for the Adaptor Proteins TRAM and TRIF in Toll-like Receptor 2 Signaling by Nilsen, Nadra J., Vladimer, Gregory I., Stenvik, Jørgen, Orning, M. Pontus A., Zeid-Kilani, Maria V., Bugge, Marit, Bergstroem, Bjarte, Conlon, Joseph, Husebye, Harald, Hise, Amy G., Fitzgerald, Katherine A., Espevik, Terje, Lien, Egil

“…Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and…”
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The role of Toll-like receptor pathways in the mechanism of type 1 diabetes by Lien, Egil, Zipris, Danny

“…Toll-like receptors (TLRs) and the innate immune system play a key role in sensing and eliminating microbial infections. Interactions between TLRs and their…”
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Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria by Pereira, Larissa M. N., Assis, Patrícia A., de Araújo, Natalia M., Durso, Danielle F., Junqueira, Caroline, Ataíde, Marco Antônio, Pereira, Dhelio B., Lien, Egil, Fitzgerald, Katherine A., Zamboni, Dario S., Golenbock, Douglas T., Gazzinelli, Ricardo T.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes by Husebye, Harald, Aune, Marie Hjelmseth, Stenvik, Jørgen, Samstad, Eivind, Skjeldal, Frode, Halaas, Øyvind, Nilsen, Nadra J., Stenmark, Harald, Latz, Eicke, Lien, Egil, Mollnes, Tom Eirik, Bakke, Oddmund, Espevik, Terje

“…Toll-like receptor 4 (TLR4) is indispensable for recognition of Gram-negative bacteria. We described a trafficking pathway for TLR4 from the endocytic…”
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Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice by Cero, Fadila Telarevic, Hillestad, Vigdis, Sjaastad, Ivar, Yndestad, Arne, Aukrust, Pål, Ranheim, Trine, Lunde, Ida Gjervold, Olsen, Maria Belland, Lien, Egil, Zhang, Lili, Haugstad, Solveig Bjærum, Løberg, Else Marit, Christensen, Geir, Larsen, Karl-Otto, Skjønsberg, Ole Henning

“…Pulmonary hypertension is a serious condition that can lead to premature death. The mechanisms involved are incompletely understood although a role for the…”
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Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response by Lien, Egil, Montminy, Sara W, Khan, Naseema, McGrath, Sara, Walkowicz, Mitchell J, Sharp, Fiona, Conlon, Joseph E, Fukase, Koichi, Kusumoto, Shoichi, Sweet, Charles, Miyake, Kensuke, Akira, Shizuo, Cotter, Robert J, Goguen, Jon D

“…At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)-lipid A with poor Toll-like receptor 4…”
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