Search Results - "LIEBER, Andre"

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival by Cieslewicz, Maryelise, Tang, Jingjing, Yu, Jonathan L., Cao, Hua, Zavaljevski, Maja, Motoyama, Koka, Lieber, Andre, Raines, Elaine W., Pun, Suzie H.

“…Most current cancer therapies focus on killing malignant cells, but these cells are often genetically unstable and can become resistant to chemotherapy…”
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An Engineered Virus Library as a Resource for the Spectrum-wide Exploration of Virus and Vector Diversity by Zhang, Wenli, Fu, Jun, Liu, Jing, Wang, Hailong, Schiwon, Maren, Janz, Sebastian, Schaffarczyk, Lukas, von der Goltz, Lukas, Ehrke-Schulz, Eric, Dörner, Johannes, Solanki, Manish, Boehme, Philip, Bergmann, Thorsten, Lieber, Andre, Lauber, Chris, Dahl, Andreas, Petzold, Andreas, Zhang, Youming, Stewart, A. Francis, Ehrhardt, Anja

“…Adenoviruses (Ads) are large human-pathogenic double-stranded DNA (dsDNA) viruses presenting an enormous natural diversity associated with a broad variety of…”
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Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 by Benlahrech, Adel, Harris, Julian, Meiser, Andrea, Papagatsias, Timos, Hornig, Julia, Hayes, Peter, Lieber, Andre, Athanasopoulos, Takis, Bachy, Veronique, Csomor, Eszter, Daniels, Rod, Fisher, Kerry, Gotch, Frances, Seymour, Len, Logan, Karen, Barbagallo, Romina, Klavinskis, Linda, Dickson, George, Patterson, Steven

“…In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of…”
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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes by Parker, Alan L., Waddington, Simon N., Nicol, Campbell G., Shayakhmetov, Dmitry M., Buckley, Suzanne M., Denby, Laura, Kemball-Cook, Geoffrey, Ni, Shaoheng, Lieber, Andre, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. When…”
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Adenovirus vectors in hematopoietic stem cell genome editing by Li, Chang, Lieber, André

“…Genome editing of hematopoietic stem cells (HSCs) represents a therapeutic option for a number of hematological genetic diseases, as HSCs have the potential…”
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CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy by Zafar, Sadia, Sorsa, Suvi, Siurala, Mikko, Hemminki, Otto, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, João Manuel, Wang, Hongjie, Lieber, Andre, De Gruijl, Tanja, Kanerva, Anna, Hemminki, Akseli

“…Dendritic cells (DCs) are crucial players in promoting immune responses. Logically, adoptive DC therapy is a promising approach in cancer immunotherapy. One of…”
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P317: Gene therapy base editors reshape single-molecule chromatin architecture of γ-globin promoters by Bohaczuk, Stephanie, Li, Chang, Dubocanin, Danilo, Mallory, Ben, Vollger, Mitchell, Lieber, Andre, Stergachis, Andrew

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Directed evolution generates a novel oncolytic virus for the treatment of colon cancer by Kuhn, Irene, Harden, Paul, Bauzon, Maxine, Chartier, Cecile, Nye, Julie, Thorne, Steve, Reid, Tony, Ni, Shaoheng, Lieber, Andre, Fisher, Kerry, Seymour, Len, Rubanyi, Gabor M, Harkins, Richard N, Hermiston, Terry W

“…Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents…”
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Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors by Alba, Raul, Bradshaw, Angela C., Coughlan, Lynda, Denby, Laura, McDonald, Robert A., Waddington, Simon N., Buckley, Suzanne M.K., Greig, Jenny A., Parker, Alan L., Miller, Ashley M., Wang, Hongjie, Lieber, Andre, van Rooijen, Nico, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.

“…A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation…”
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Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy by Zafar, Sadia, Parviainen, Suvi, Siurala, Mikko, Hemminki, Otto, Havunen, Riikka, Tähtinen, Siri, Bramante, Simona, Vassilev, Lotta, Wang, Hongjie, Lieber, Andre, Hemmi, Silvio, de Gruijl, Tanja, Kanerva, Anna, Hemminki, Akseli

“…Vaccination with dendritic cells (DCs), the most potent professional antigen-presenting cells in the body, is a promising approach in cancer immunotherapy…”
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Discovery of Novel Methylation Biomarkers in Cervical Carcinoma by Global Demethylation and Microarray Analysis by SOVA, Pavel, QINGHUA FENG, GEISS, Gary, WOOD, Troy, STRAUSS, Robert, RUDOLF, Vania, LIEBER, Andre, KIVIAT, Nancy

“…A genome-wide screening study for identification of hypermethylated genes in invasive cervical cancer (ICC) was carried out to augment our previously…”
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In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model by Li, Chang, Wang, Hongjie, Georgakopoulou, Aphrodite, Gil, Sucheol, Yannaki, Evangelia, Lieber, André

“…We have recently reported that, after in vivo hematopoietic stem cell/progenitor (HSPC) transduction with HDAd5/35++ vectors, SB100x transposase-mediated…”
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Two types of functionally distinct fiber containing structural protein complexes are produced during infection of adenovirus serotype 5 by Zhang, Bo, Yan, Yuhua, Jin, Jie, Lin, Hongyu, Li, Zongyi, Zhang, Xiaoyan, Liu, Jin, Xi, Chao, Lieber, Andre, Fan, Xiaolong, Ran, Liang

“…Adenoviruses are common pathogens. The localization of their receptors coxsackievirus and adenovirus receptor, and desmoglein-2 in cell-cell junction complexes…”
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Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy by Ulasov, Ilya V, Shah, Nameeta, Kaverina, Natalya V, Lee, Hwahyang, Lin, Biaoyang, Lieber, Andre, Kadagidze, Zaira G, Yoon, Jae-Guen, Schroeder, Brett, Hothi, Parvinder, Ghosh, Dhimankrishna, Baryshnikov, Anatoly Y, Cobbs, Charles S

“…Oncolytic gene therapy using viral vectors may provide an attractive therapeutic option for malignant gliomas. These viral vectors are designed in a way to…”
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Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity by SHAYAKHMETOV, Dmitry M, GAGGAR, Anuj, SHAOHENG NI, LI, Zong-Yi, LIEBER, André

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement by Vassal-Stermann, Emilie, Effantin, Gregory, Zubieta, Chloe, Burmeister, Wim, Iseni, Frédéric, Wang, Hongjie, Lieber, André, Schoehn, Guy, Fender, Pascal

“…Attachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a…”
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Prospects and challenges of in vivo hematopoietic stem cell genome editing for hemoglobinopathies by Lieber, André, Kiem, Hans-Peter

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Quantification of designer nuclease induced mutation rates: a direct comparison of different methods by Ehrke-Schulz, Eric, Bergmann, Thorsten, Schiwon, Maren, Doerner, Johannes, Saydaminova, Kamola, Lieber, Andre, Ehrhardt, Anja

“…Designer nucleases are broadly applied to induce site-specific DNA double-strand breaks (DSB) in genomic DNA. These are repaired by nonhomologous end joining…”
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Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing by Li, Chang, Psatha, Nikoletta, Sova, Pavel, Gil, Sucheol, Wang, Hongjie, Kim, Jiho, Kulkarni, Chandana, Valensisi, Cristina, Hawkins, R. David, Stamatoyannopoulos, George, Lieber, André

“…Disorders involving β-globin gene mutations, primarily β-thalassemia and sickle cell disease, represent a major target for hematopoietic stem/progenitor cell…”
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CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells by Wang, Hongjie, Koob, Theo, Fromm, Jonathan R, Gopal, Ajay, Carter, Darrick, Lieber, André

“…Multiple myeloma (MM) is an incurable malignancy of the B-cell lineage. Remarkable progress has been made in the treatment of MM with anti-CD38 monoclonal…”
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