Search Results - "LICEA, Monica"

Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer by Moore, Paul A, Shah, Kalpana, Yang, Yinhua, Alderson, Ralph, Roberts, Penny, Long, Vatana, Liu, Daorong, Li, Jonathan C, Burke, Steve, Ciccarone, Valentina, Li, Hua, Fieger, Claudia B, Hooley, Jeff, Easton, Ann, Licea, Monica, Gorlatov, Sergey, King, Kathy L, Young, Peter, Adami, Arash, Loo, Deryk, Chichili, Gurunadh R, Liu, Liqin, Smith, Douglas H, Brown, Jennifer G, Chen, Francine Z, Koenig, Scott, Mather, Jennie, Bonvini, Ezio, Johnson, Syd

“…We have developed MGD007 (anti-glycoprotein A33 x anti-CD3), a DART protein designed to redirect T cells to target gpA33 expressing colon cancer. The gpA33…”
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Development of an Fc-Enhanced Anti―B7-H3 Monoclonal Antibody with Potent Antitumor Activity by LOO, Deryk, ALDERSON, Ralph F, SON, Tom, YAN CHEN, EASTON, Ann N, LI, Jonathan C, RILLEMA, Jill R, LICEA, Monica, FIEGER, Claudia, LIANG, Tony W, MATHER, Jennie P, KOENIG, Scott, CHEN, Francine Z, STEWART, Stanford J, JOHNSON, Syd, BONVINI, Ezio, MOORE, Paul A, LING HUANG, WENJUN ZHANG, GORLATOV, Sergey, BURKE, Steve, CICCARONE, Valentina, HUA LI, YINHUA YANG

“…The goal of this research was to harness a monoclonal antibody (mAb) discovery platform to identify cell-surface antigens highly expressed on cancer and…”
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Abstract 1498: Development of an IL13Ralpha2 x CD3 bispecific DART® protein for redirected T-cell killing of solid tumors by Rillema, Jill, Licea, Monica, Saini-Lal, Shereen, Smith, Doug, Chen, Francine, Lam, Annie, Yang, Yinhua, Liu, Liqin, Tamura, James, Alderson, Ralph, Bonvini, Ezio, Johnson, Syd, Moore, Paul

“…Introduction. IL13Rα2 is a membrane-bound protein expressed on a number of malignant tumors, but not at significant levels in most normal tissues. Clinically…”
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Abstract 38: Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors by Scribner, Juniper A., Barat, Bhaswati, Hicks, Stuart W., Yoder, Nicholas C., Son, Thomas, Widjaja, Lusiana, Diedrich, Gundo, Gorlatov, Sergey, Hooley, Jeff, Easton, Ann, Lung, Peter, Costa, Anushka De, Chen, Francine, Chiechi, Michael, Li, Pam, Licea, Monica, Hotaling, Timothy E., Spliedt, Michael, Ciccarone, Valentina, Gantt, Nadia, Tamura, James, Fuller, Megan E., McShea, Molly, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk

“…Introduction: A target-unbiased approach based on intact cell immunizations with fetal progenitor cells and cancer stem cells, followed by an…”
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Abstract 3217: MGD013, a bispecific PD-1 x LAG-3 Dual-Affinity Re-Targeting (DART®) protein with T-cell immunomodulatory activity for cancer treatment by LaMotte-Mohs, Ross, Shah, Kalpana, Smith, Doug, Gorlatov, Sergey, Ciccarone, Valentina, Tamura, James, Li, Hua, Rillema, Jill, Licea, Monica, He, Leilei, Vasanwala, Farha, Chen, Wei, Yao, Xiao-Tao, Chen, Francine, Brown, Jennifer, Nordstrom, Jeffrey, Koenig, Scott, Bonvini, Ezio, Johnson, Syd, Moore, Paul

“…Introduction: The combination of monoclonal antibodies (mAbs) that targets the immune checkpoint molecules CTLA-4 and PD-1 has shown clinical benefit beyond…”
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Abstract 3763: Identification of gpA33 as a marker expressed on colon cancer stem cell lines by Li, Jonathan, Fieger, Claudia B., Roberts, Penny, Smith, Doug, Licea, Monica, Hooley, Jeff, Chen, Francine, King, Kathy, Mather, Jennie, Bonvini, Ezio, Loo, Deryk, Moore, Paul A.

“…Introduction: Recent studies have implied that solid tumors including colon cancer, can arise from tissue-specific stem cells. Defined serum-free culture…”
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Abstract 2725: Preclinical development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent anti-tumor activity by Loo, Deryk T., Alderson, Ralph, Chen, Francine, Huang, Ling, Zhang, Wenjun, Gorlatov, Sergey, Burke, Steve, Ciccarone, Valentina, Li, Hua, Yang, Yinhua, Son, Thomas, Chen, Yan, Li, Jonathan, Rillema, Jill, Licea, Monica, Liang, Tony, Mather, Jennie P., Koenig, Scott, Stewart, Stanford J., Johnson, Syd, Bonvini, Ezio, Moore, Paul

“…Antigens that are tumor-specific or over-expressed on cancer cells represent opportunities for developing target-specific antibody-based therapeutics…”
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