Search Results - "LIBRA, MASSIMO"

Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium by Falzone, Luca, Salomone, Salvatore, Libra, Massimo

“…The medical history of cancer began millennia ago. Historical findings of patients with cancer date back to ancient Egyptian and Greek civilizations, where…”
Get full text

Current and innovative methods for the diagnosis of COVID‑19 infection (Review) by Falzone, Luca, Gattuso, Giuseppe, Tsatsakis, Aristidis, Spandidos, Demetrios A, Libra, Massimo

“…The Coronavirus Disease 2019 (COVID‑19) pandemic has forced the scientific community to rapidly develop highly reliable diagnostic methods in order to…”
Get full text

Current Perspectives in Cancer Immunotherapy by Christofi, Theodoulakis, Baritaki, Stavroula, Falzone, Luca, Libra, Massimo, Zaravinos, Apostolos

“…Different immunotherapeutic approaches have proved to be of significant clinical value to many patients with different types of advanced cancer. However, we…”
Get full text

Gut Microbiota and Cancer: From Pathogenesis to Therapy by Vivarelli, Silvia, Salemi, Rossella, Candido, Saverio, Falzone, Luca, Santagati, Maria, Stefani, Stefania, Torino, Francesco, Banna, Giuseppe Luigi, Tonini, Giuseppe, Libra, Massimo

“…Cancer is a multifactorial pathology and it represents the second leading cause of death worldwide. In the recent years, numerous studies highlighted the dual…”
Get full text

Cutaneous melanoma and the immunotherapy revolution (Review) by Leonardi, Giulia C, Candido, Saverio, Falzone, Luca, Spandidos, Demetrios A, Libra, Massimo

“…In a relatively short period of time, treatment strategies for metastatic melanoma have radically changed leading to an unprecedented improvement in patient…”
Get full text

Ageing: from inflammation to cancer by Leonardi, Giulia C, Accardi, Giulia, Monastero, Roberto, Nicoletti, Ferdinando, Libra, Massimo

“…Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic…”
Get full text

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review) by NITULESCU, GEORGE MIHAI, MARGINA, DENISA, JUZENAS, PETRAS, PENG, QIAN, OLARU, OCTAVIAN TUDOREL, SALOUSTROS, EMMANOUIL, FENGA, CONCETTINA, SPANDIDOS, DEMETRIOS A, LIBRA, MASSIMO, TSATSAKIS, ARISTIDIS M

“…Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are…”
Get full text

Cancer-associated stroke: Pathophysiology, detection and management (Review) by Dardiotis, Efthimios, Aloizou, Athina-Maria, Markoula, Sofia, Siokas, Vasileios, Tsarouhas, Konstantinos, Tzanakakis, Georgios, Libra, Massimo, Kyritsis, Athanassios P, Brotis, Alexandros G, Aschner, Michael, Gozes, Illana, Bogdanos, Dimitrios P, Spandidos, Demetrios A, Mitsias, Panayiotis D, Tsatsakis, Aristidis

“…Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of…”
Get full text

Novel Insights into Epigenetic Regulation of IL6 Pathway: In Silico Perspective on Inflammation and Cancer Relationship by Candido, Saverio, Tomasello, Barbara Maria Rita, Lavoro, Alessandro, Falzone, Luca, Gattuso, Giuseppe, Libra, Massimo

“…IL-6 pathway is abnormally hyperactivated in several cancers triggering tumor cell growth and immune system inhibition. Along with genomic mutation, the IL6…”
Get full text

The S100A7 nuclear interactors in autoimmune diseases: a coevolutionary study in mammals by D’Amico, Fabio, Skarmoutsou, Evangelia, Libra, Massimo

“…S100A7, a member of the S100A family of Ca 2+ -binding proteins, is considered a key effector in immune response. In particular, S100A7 dysregulation has been…”
Get full text

YY1 Silencing Induces 5-Fluorouracil-Resistance and BCL2L15 Downregulation in Colorectal Cancer Cells: Diagnostic and Prognostic Relevance by Vivarelli, Silvia, Falzone, Luca, Candido, Saverio, Bonavida, Benjamin, Libra, Massimo

“…Colorectal cancer (CRC) is characterized by genetic heterogeneity and is often diagnosed at an advanced stage. Therefore, there is a need to identify novel…”
Get full text

Novel insights on gut microbiota manipulation and immune checkpoint inhibition in cancer (Review) by Vivarelli, Silvia, Falzone, Luca, Leonardi, Giulia Costanza, Salmeri, Mario, Libra, Massimo

“…Cancer affects millions of individuals worldwide. Thus, there is an increased need for the development of novel effective therapeutic approaches. Tumorigenesis…”
Get full text

Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant by Salemi, Rossella, Vivarelli, Silvia, Ricci, Daria, Scillato, Marina, Santagati, Maria, Gattuso, Giuseppe, Falzone, Luca, Libra, Massimo

“…Gut microbiota modulation has been demonstrated to be effective in protecting patients against detrimental effects of anti-cancer therapies, as well as to…”
Get full text

The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action by Grosso, Giuseppe, Godos, Justyna, Currenti, Walter, Micek, Agnieszka, Falzone, Luca, Libra, Massimo, Giampieri, Francesca, Forbes-Hernández, Tamara Y, Quiles, José L, Battino, Maurizio, La Vignera, Sandro, Galvano, Fabio

“…The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on…”
Get full text

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer by Duda, Przemysław, Akula, Shaw M, Abrams, Stephen L, Steelman, Linda S, Martelli, Alberto M, Cocco, Lucio, Ratti, Stefano, Candido, Saverio, Libra, Massimo, Montalto, Giuseppe, Cervello, Melchiorre, Gizak, Agnieszka, Rakus, Dariusz, McCubrey, James A

“…Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of…”
Get full text

Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma by Napoli, Salvatore, Scuderi, Chiara, Gattuso, Giuseppe, Bella, Virginia Di, Candido, Saverio, Basile, Maria Sofia, Libra, Massimo, Falzone, Luca

“…The extracellular matrix (ECM) plays an important role in the regulation of the tissue microenvironment and in the maintenance of cellular homeostasis. Several…”
Get full text

Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme by Stella, Michele, Falzone, Luca, Caponnetto, Angela, Gattuso, Giuseppe, Barbagallo, Cristina, Battaglia, Rosalia, Mirabella, Federica, Broggi, Giuseppe, Altieri, Roberto, Certo, Francesco, Caltabiano, Rosario, Barbagallo, Giuseppe Maria Vincenzo, Musumeci, Paolo, Ragusa, Marco, Pietro, Cinzia Di, Libra, Massimo, Purrello, Michele, Barbagallo, Davide

“…Glioblastoma multiforme (GBM) is the most frequent and deadly human brain cancer. Early diagnosis through non-invasive biomarkers may render GBM more easily…”
Get full text

Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain by Falzone, Luca, Lavoro, Alessandro, Candido, Saverio, Salmeri, Mario, Zanghì, Antonino, Libra, Massimo

“…Recently, the mounting integration of probiotics into human health strategies has gathered considerable attention. Although the benefits of probiotics have…”
Get full text

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance by McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Chang, Fumin, Lehmann, Brian, Terrian, David M., Milella, Michele, Tafuri, Agostino, Stivala, Franca, Libra, Massimo, Basecke, Jorg, Evangelisti, Camilla, Martelli, Alberto M., Franklin, Richard A.

“…Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent…”
Get full text

Ketogenic Diet and Breast Cancer: Recent Findings and Therapeutic Approaches by Urzì, Alfio Giuseppe, Tropea, Emanuela, Gattuso, Giuseppe, Spoto, Graziana, Marsala, Gabriella, Calina, Daniela, Libra, Massimo, Falzone, Luca

“…Breast cancer (BC), a complex disease with several influencing factors, is significantly impacted by dietary habits. The ketogenic diet (KD), characterized by…”
Get full text