Pharmacokinetics of tolfenamic acid in pediatric patients after single oral dose

Pharmacokinetics of tolfenamic acid in pediatric patients after single oral dose

The pharmacokinetics of tolfenamic acid, a non-steroidal anti-inflammatory drug, were determined following administration of a 1 mg/kg single oral dose of tolfenamic acid suspension to 6 feverish children. Their ages were from 2-14 years (mean 7.5 years) and their weights were from 12-50 kg (mean 29...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics Vol. 20; no. 4; pp. 293 - 296
Main Authors: NIOPAS, I, GEORGARAKIS, M, SIDI-FRANGANDREA, V, CHRISANTHOPOULOS, C, LIARA, E
Format: Journal Article
Language:English
Published: Genève Médecine et hygiène 01-10-1995
Subjects:
Administration, Oral
Adolescent
Analgesics
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - blood
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Biological and medical sciences
Child
Child, Preschool
Female
Fever - metabolism
Fever - therapy
Humans
Male
Medical sciences
Neuropharmacology
ortho-Aminobenzoates - administration & dosage
ortho-Aminobenzoates - blood
ortho-Aminobenzoates - pharmacokinetics
Pharmacology. Drug treatments
Human
Non steroidal antiinflammatory agent
Chemotherapy
Treatment
Single dose
Oral administration
Antipyretic
Pharmacokinetics
Child
Fever
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Summary:The pharmacokinetics of tolfenamic acid, a non-steroidal anti-inflammatory drug, were determined following administration of a 1 mg/kg single oral dose of tolfenamic acid suspension to 6 feverish children. Their ages were from 2-14 years (mean 7.5 years) and their weights were from 12-50 kg (mean 29.2 kg). Tolfenamic acid produced a significant fall in temperature (about 2 degrees C) compared to the initial value before oral intake of the drug and was well tolerated without adverse effects. Blood samples for determination of tolfenamic acid concentrations in plasma were obtained at timed intervals for up to 8 h post-dose. Plasma concentrations of tolfenamic acid were determined using a reversed phase HPLC method and pertinent pharmacokinetic parameters were estimated by model-independent standard methods and were the following: the mean peak plasma concentration (Cmax +/- SEM) was 1.09 +/- 0.44 micrograms/ml (range, 0.65-1.63 micrograms/ml) and the mean time (tmax +/- SEM) to reach peak plasma concentration was 1.4 +/- 0.4 h (range, 0.5-3.0 h). The mean area under the plasma concentration-time curve (AUC0-->infinity +/- SEM) was 4.61 +/- 0.40 micrograms.h/ml (range, 2.74-5.98 micrograms.h/ml), the mean elimination half-life (t1/2 +/- SEM) was 2.82 +/- 0.21 h (range, 2.19-3.40 h) and the mean apparent total clearance (CL/F +/- SEM) was 3.83 +/- 0.41 ml/min/kg (range, 2.79-6.08 ml/min/kg).
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ISSN:0378-7966
2107-0180
DOI:10.1007/BF03190247