Search Results - "LIANGYOU RUI"

Brain regulation of energy balance and body weight by Rui, Liangyou

“…Body weight is determined by a balance between food intake and energy expenditure. Multiple neural circuits in the brain have evolved to process information…”
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SH2B1 regulation of energy balance, body weight, and glucose metabolism by Rui, Liangyou

“…The Src homology 2B(SH2B)family members(SH2B1,SH2B2 and SH2B3)are adaptor signaling proteins containing characteristic SH2 and PH domains.SH2B1(also called…”
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Recent advances in understanding leptin signaling and leptin resistance by Morris, David L, Rui, Liangyou

“…The brain controls energy homeostasis and body weight by integrating various metabolic signals. Leptin, an adipose-derived hormone, conveys critical…”
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Brown and Beige Adipose Tissues in Health and Disease by Rui, Liangyou

“…Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue (BAT) develops embryonically from precursors that also give to…”
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Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease by Jiang, Lin, Su, Haoran, Wu, Xiaoyin, Shen, Hong, Kim, Min-Hyun, Li, Yuan, Myers, Martin G., Owyang, Chung, Rui, Liangyou

“…Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here,…”
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Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity by Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng

“…Cullin-RING E3 ligases (CRLs) regulate the turnover of approximately 20% of mammalian cellular proteins. Neddylation of individual cullin proteins is essential…”
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Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity by Liu, Yan, Sheng, Liang, Xiong, Yi, Shen, Hong, Liu, Yong, Rui, Liangyou

“…Obesity is associated with chronic inflammation and liver steatoses. Numerous proinflammatory cytokines have been reported to regulate liver glucose and lipid…”
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Intestinal non-canonical NFκB signaling shapes the local and systemic immune response by Ramakrishnan, Sadeesh K., Zhang, Huabing, Ma, Xiaoya, Jung, Inkyung, Schwartz, Andrew J., Triner, Daniel, Devenport, Samantha N., Das, Nupur K., Xue, Xiang, Zeng, Melody Y., Hu, Yinling, Mortensen, Richard M., Greenson, Joel K, Cascalho, Marilia, Wobus, Christiane E., Colacino, Justin A., Nunez, Gabriel, Rui, Liangyou, Shah, Yatrik M.

“…Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the…”
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A small‐molecule inhibitor of NF‐κB‐inducing kinase (NIK) protects liver from toxin‐induced inflammation, oxidative stress, and injury by Ren, Xiaomeng, Li, Xinzhi, Jia, Linna, Chen, Deheng, Hou, Hai, Rui, Liangyou, Zhao, Yujun, Chen, Zheng

“…ABSTRACT Potent and selective chemical probes are valuable tools for discovery of novel treatments for human diseases. NF‐κβ‐inducing kinase (NIK) is a key…”
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Dual role for inositol‐requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet‐induced obesity in mice by Wu, Ying, Shan, Bo, Dai, Jianli, Xia, Zhixiong, Cai, Jie, Chen, Tianwei, Lv, Songya, Feng, Yuxiong, Zheng, Ling, Wang, Yan, Liu, Jianfeng, Fang, Jing, Xie, Dong, Rui, Liangyou, Liu, Jianmiao, Liu, Yong

“…Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic inflammation. ER stress activates the unfolded protein response (UPR)…”
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Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice by Zhou, Yingjiang, Jiang, Lin, Rui, Liangyou

“…Major urinary protein (MUP) 1 is a lipocalin family member abundantly secreted into the circulation by the liver. MUP1 binds to lipophilic pheromones and is…”
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Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice by Shen, Hong, Jiang, Lin, Lin, Jiandie D, Omary, M Bishr, Rui, Liangyou

“…Chronic alcohol consumption causes liver injury, inflammation and fibrosis, thereby increasing morbidity and mortality. Paradoxically, modest drinking is…”
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Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity by Zhang, Deqiang, Tong, Xin, VanDommelen, Kyle, Gupta, Neil, Stamper, Kenneth, Brady, Graham F, Meng, Zhuoxian, Lin, Jiandie, Rui, Liangyou, Omary, M Bishr, Yin, Lei

“…Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms…”
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Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis by Liu, Yan, Jiang, Lin, Sun, Chengxin, Ireland, Nicole, Shah, Yatrik M., Liu, Yong, Rui, Liangyou

“…Insulin stimulates lipogenesis but insulin resistance is also associated with increased hepatic lipogenesis in obesity. However, the underlying mechanism…”
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Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling by Zhang, Deqiang, Tong, Xin, Arthurs, Blake, Guha, Anirvan, Rui, Liangyou, Kamath, Avani, Inoki, Ken, Yin, Lei

“…The clock protein BMAL1 (brain and muscle Arnt-like protein 1) participates in circadian regulation of lipid metabolism, but its contribution to insulin…”
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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice by Wang, Pingping, Kang, Qianqian, Wu, Wen-Shu, Rui, Liangyou

“…Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces…”
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Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice by Zhang, Zhiguo, Zhong, Xiao, Shen, Hong, Sheng, Liang, Liangpunsakul, Suthat, Lok, Anna S., Omary, M. Bishr, Wang, Shaomeng, Rui, Liangyou

“…Excessive cholangiocyte expansion (ductular reaction) promotes liver disease progression, but the underlying mechanism is poorly understood. Here we identify…”
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Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes by Liu, Yan, Lin, Haiyan, Jiang, Lin, Shang, Qingsen, Yin, Lei, Lin, Jiandie D, Wu, Wen-Shu, Rui, Liangyou

“…De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity,…”
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LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice by Kim, Min-Hyun, Li, Yuan, Zheng, Qiantao, Jiang, Lin, Myers, Jr, Martin G, Wu, Wen-Shu, Rui, Liangyou

“…Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to…”
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Major Urinary Protein Regulation of Chemical Communication and Nutrient Metabolism by Zhou, Yingjiang, Rui, Liangyou

“…The major urinary protein (MUP) family members contain a conserved β-barrel structure with a characteristic central hydrophobic pocket. They are secreted by…”
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