Search Results - "LEY, Steven C."

ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation by Webb, Louise V., Ventura, Sonia, Ley, Steven C.

“…Mammalian TPL-2 kinase (MAP3K8) mediates Toll-like receptor activation of ERK1/2 and p38α MAP kinases and is critical for regulating immune responses to…”
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Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation by Howes, Ashleigh, O'Sullivan, Paul A, Breyer, Felix, Ghose, Ashavari, Cao, Li, Krappmann, Daniel, Bowcock, Anne M, Ley, Steven C

“…Inherited and de novo mutations in the CARD14 gene promote the development of psoriasis, an inflammatory disease of the skin. Caspase recruitment…”
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Expression, biological activities and mechanisms of action of A20 (TNFAIP3) by Verstrepen, Lynn, Verhelst, Kelly, van Loo, Geert, Carpentier, Isabelle, Ley, Steven C., Beyaert, Rudi

“…A20 (also known as TNFAIP3) is a cytoplasmic protein that plays a key role in the negative regulation of inflammation and immunity. Polymorphisms in the A20…”
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Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer by Bespalov, Daniil, Pino, Dayana, Vidal-Guirao, Sònia, Franquesa, Júlia, Lopez-Ramajo, Daniel, Filgaira, Ingrid, Wan, Li, O’Sullivan, Paul A., Ley, Steven C., Forcales, Sonia Vanina, Rojas, Juan José, Izquierdo-Serra, Mercè, Soler, Concepció, Manils, Joan

“…Aberrant caspase recruitment domain family member 14 (CARD14) signaling has been strongly associated with inflammatory skin conditions. CARD14 acts as a…”
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p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation by Risco, Ana, del Fresno, Carlos, Mambol, Agnes, Alsina-Beauchamp, Dayanira, MacKenzie, Kirsty F, Yang, Huei-Ting, Barber, Domingo F, Morcelle, Carmen, Arthur, J. Simon C, Ley, Steven C, Ardavin, Carlos, Cuenda, Ana

“…On the basis mainly of pharmacological experiments, the p38α MAP kinase isoform has been established as an important regulator of immune and inflammatory…”
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ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism by Nanda, Sambit K, Nagamori, Tsunehisa, Windheim, Mark, Amu, Sylvia, Aviello, Gabriella, Patterson-Kane, Janet, Arthur, J Simon C, Ley, Steven C, Fallon, Padraic, Cohen, Philip

“…The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2)…”
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NF-κB signaling mediates homeostatic maturation of new T cells by Silva, Ana, Cornish, Georgina, Ley, Steven C., Seddon, Benedict

“…Interleukin (IL)-7 is critical for the maintenance of the peripheral T-cell compartment of the adaptive immune system. IL-7 receptor α (IL-7Rα) expression is…”
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Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105 by Yang, Huei-Ting, Papoutsopoulou, Stamatia, Belich, Monica, Brender, Christine, Janzen, Julia, Gantke, Thorsten, Handley, Matt, Ley, Steven C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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p38γ and p38δ modulate innate immune response by regulating MEF2D activation by Escós, Alejandra, Diaz-Mora, Ester, Pattison, Michael, Fajardo, Pilar, González-Romero, Diego, Risco, Ana, Martín-Gómez, José, Bonneil, Éric, Sonenberg, Nahum, Jafarnejad, Seyed Mehdi, Sanz-Ezquerro, Juan José, Ley, Steven C, Cuenda, Ana

“…Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using -deficient (p38γ/δKO) mice, which show low levels of TPL2,…”
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IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases by Ben-Addi, Abduelhakem, Mambole-Dema, Agnes, Brender, Christine, Martin, Stephen R, Janzen, Julia, Kjaer, Sven, Smerdon, Stephen J, Ley, Steven C

“…The MEK-1/2 kinase TPL-2 is critical for Toll-like receptor activation of the ERK-1/2 MAP kinase pathway during inflammatory responses, but it can transform…”
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Posttranslational Hydroxylation of Ankyrin Repeats in IκB Proteins by the Hypoxia-Inducible Factor (HIF) Asparaginyl Hydroxylase, Factor Inhibiting HIF (FIH) by Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.

“…Studies on hypoxia-sensitive pathways have revealed a series of Fe(ll)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and…”
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IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400 by Roget, Karine, Ben-Addi, Abduelhakem, Mambole-Dema, Agnes, Gantke, Thorsten, Yang, Huei-Ting, Janzen, Julia, Morrice, Nick, Abbott, Derek, Ley, Steven C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mitogen-activated protein kinases in innate immunity by Arthur, J. Simon C., Ley, Steven C.

“…Key Points Mitogen-activated protein kinases (MAPKs) in innate immune cells are activated by a range of pattern recognition receptors, of which the best…”
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TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus by Kannan, Yashaswini, Entwistle, Lewis J, Pelly, Victoria S, Perez-Lloret, Jimena, Walker, Alan W, Ley, Steven C, Wilson, Mark S

“…TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2…”
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TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology by Kannan, Yashaswini, Perez-Lloret, Jimena, Li, Yanda, Entwistle, Lewis J, Khoury, Hania, Papoutsopoulou, Stamatia, Mahmood, Radma, Mansour, Nuha R, Ching-Cheng Huang, Stanley, Pearce, Edward J, Pedro S de Carvalho, Luiz, Ley, Steven C, Wilson, Mark S

“…Persistent TH2 cytokine responses following chronic helminth infections can often lead to the development of tissue pathology and fibrotic scarring. Despite a…”
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Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells by Kannan, Yashaswini, PhD, Li, Yanda, BS, Coomes, Stephanie M., PhD, Okoye, Isobel S., PhD, Pelly, Victoria S., PhD, Sriskantharajah, Srividya, PhD, Gückel, Eva, PhD, Webb, Lauren, PhD, Czieso, Stephanie, BS, Nikolov, Nikolay, PhD, MacDonald, Andrew S., PhD, Ley, Steven C., PhD, Wilson, Mark S., PhD

“…Background The molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. Tumor progression locus 2 (TPL-2) (COT, MAP3K8)…”
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Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells by Gantke, Thorsten, Boussouf, Sabrina, Janzen, Julia, Morrice, Nicholas A, Howell, Steven, Mühlberger, Elke, Ley, Steven C

“…Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced…”
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A20 inactivation in ocular adnexal MALT lymphoma by BI, Yingwen, NAIYAN ZENG, RONGJIA CHEN, XIONGZENG ZHU, DU, Ming-Qing, CHANUDET, Estelle, YUANXUE HUANG, HAMOUDI, Rifat A, HONGXIANG LIU, GEHONG DONG, JAMES WATKINS, A, LEY, Steven C, LIFEN ZOU

“…Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma. However,…”
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TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability by Mieulet, Virginie, Yan, Lijun, Choisy, Caroline, Sully, Katherine, Procter, Julia, Kouroumalis, Andreas, Krywawych, Steve, Pende, Mario, Ley, Steven C, Moinard, Christophe, Lamb, Richard F

“…The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated…”
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Identification of a Macrophage-Specific Chromatin Signature in the IL-10 Locus by Saraiva{paragraph}, Margarida, Christensen, Jillian R, Tsytsykova, Alla V, Goldfeld, Anne E, Ley, Steven C, Kioussis, Dimitris, O'Garra, Anne

“…The molecular mechanisms that regulate expression of the immunosuppressive cytokine IL-10 remain poorly understood. In this study, by measuring sensitivity to…”
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