Search Results - "LEWIS, Michael C"

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
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Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors by Fernandez, Stephanie M, Lewis, Michael C, Pechenino, Angela S, Harburger, Lauren L, Orr, Patrick T, Gresack, Jodi E, Schafe, Glenn E, Frick, Karyn M

“…The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning and memory, and is activated by the potent estrogen…”
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A fractionation of the physiological burden of the personal protective equipment worn by firefighters by Taylor, Nigel A. S., Lewis, Michael C., Notley, Sean R., Peoples, Gregory E.

“…Load carriage increases physiological strain, reduces work capacity and elevates the risk of work-related injury. In this project, the separate and combined…”
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Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation by Fan, Lu, Zhao, Zaorui, Orr, Patrick T, Chambers, Cassie H, Lewis, Michael C, Frick, Karyn M

“…We previously demonstrated that dorsal hippocampal extracellular signal-regulated kinase (ERK) activation is necessary for 17beta-estradiol (E(2)) to enhance…”
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Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases by Wagner, Florence F., Weїwer, Michel, Lewis, Michael C., Holson, Edward B.

“…Lysine acetylation is an ancient, evolutionarily conserved, reversible post-translational modification. A multitude of diverse cellular functions are regulated…”
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AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice by PAN, Jen Q, LEWIS, Michael C, NEVE, Rachael L, BIECHELE, Travis L, MOON, Randall T, SCOLNICK, Edward M, PETRYSHEN, Tracey L, HAGGARTY, Stephen J, KETTERMAN, Josh K, CLORE, Elizabeth L, RILEY, Misha, RICHARDS, Keenan R, BERRY-SCOTT, Erin, XIULIN LIU, WAGNER, Florence F, HOLSON, Edward B

“…Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting ∼2% of the worldwide population, for which the etiological basis, pathogenesis, and…”
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The Ethics of Surgery at End of Life by Lewis, Michael C., MD, Yeldo, Nicholas S., MD

“…The role of the anesthesiologist cannot be understated when it comes to ethical decision making, especially at end of life. To best serve patients within the…”
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Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain by Mawhinney, Lana J, de Rivero Vaccari, Juan Pablo, Alonso, Ofelia F, Jimenez, Christopher A, Furones, Concepción, Moreno, W. Javier, Lewis, Michael C, Dietrich, W. Dalton, Bramlett, Helen M

“…Abstract Postoperative cognitive dysfunction, POCD, afflicts a large number of elderly surgical patients following surgery with general anesthesia. Mechanisms…”
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Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines by Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M

“…A potent, selective, orally active LXR agonist was identified from focused libraries of tertiary amines. GW3965 (12) recruits the steroid receptor coactivator…”
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Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR by Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M

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Reversible inactivation of the entorhinal cortex disrupts the establishment and expression of latent inhibition of cued fear conditioning in C57BL/6 mice by Lewis, Michael C., Gould, Thomas J.

“…For latent inhibition, preexposure to a conditioned stimulus (CS) prior to training with an unconditioned stimulus (US) results in decreased conditioned…”
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A review of four case studies assessing the potential for hydrogen penetration of the future energy system by Chapman, Andrew, Itaoka, Kenshi, Hirose, Katsuhiko, Davidson, F. Todd, Nagasawa, Kazunori, Lloyd, Alan C., Webber, Michael E., Kurban, Zeynep, Managi, Shunsuke, Tamaki, Tetsuya, Lewis, Michael C., Hebner, Robert E., Fujii, Yasumasa

“…Hydrogen as an energy carrier allows the decarbonization of transport, industry, and space heating as well as storage for intermittent renewable energy. The…”
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Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features by Madison, Jon M., Duong, Karen, Vieux, Ellen F., Udeshi, Namrata D., Iqbal, Sumaiya, Requadt, Elise, Fereshetian, Shaunt, Lewis, Michael C., Gomes, Antonio S., Pierce, Kerry A., Platt, Randall J., Zhang, Feng, Campbell, Arthur J., Lal, Dennis, Wagner, Florence F., Clish, Clary B., Carr, Steven A., Sheng, Morgan, Scolnick, Edward M., Cottrell, Jeffrey R.

“…Genetic variation of the 16p11.2 deletion locus containing the KCTD13 gene and of CUL3 is linked with autism. This genetic connection suggested that substrates…”
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Geriatrics and the Perioperative Surgical Home by Mello, Matthew T., MD, Azocar, Ruben J., MD, Lewis, Michael C., MBBS

“…An ever-changing health care system with a constantly increasing aging surgical population creates both opportunities for providing improved health care as…”
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Expanded spatial extent of the Medieval Climate Anomaly revealed in lake‐sediment records across the boreal region in northwest Ontario by Laird, Kathleen R, Haig, Heather A, Ma, Susan, Kingsbury, Melanie V, Brown, Thomas A, Lewis, C. F. Michael, Oglesby, Robert J, Cumming, Brian F

“…Multi‐decadal to centennial‐scale shifts in effective moisture over the past two millennia are inferred from sedimentary records from six lakes spanning a ~250…”
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Atomoxetine and nicotine enhance prepulse inhibition of acoustic startle in C57BL/6 mice by Gould, Thomas J., Rukstalis, Margaret, Lewis, Michael C.

“…Deficits in sensory-gating, often measured as deficits in prepulse inhibition of acoustic startle (PPI), are associated multiple with disorders including…”
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Introduction to “Holocene water levels and paleo-hydrology of the Laurentian Great Lakes” by Michael Lewis, C. F., King, John W.

“…Issue Title: Special issue: Holocene water levels and paleo-hydrology of the Laurentian Great Lakes…”
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Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐d‐aspartate receptors by Beckley, Jacob T., Aman, Teresa K., Ackley, Michael A., Kazdoba, Tatiana M., Lewis, Michael C., Smith, Anne C., Farley, Brandon J., Dai, Jing, Deats, Wayne, Hoffmann, Ethan, Robichaud, Albert J., Doherty, James J., Quirk, Michael C.

“…Background and Purpose Select neuroactive steroids tune neural activity by modulating excitatory and inhibitory neurotransmission, including the endogenous…”
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Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome by McCamphill, Patrick K, Stoppel, Laura J, Senter, Rebecca K, Lewis, Michael C, Heynen, Arnold J, Stoppel, David C, Sridhar, Vinay, Collins, Katie A, Shi, Xi, Pan, Jen Q, Madison, Jon, Cottrell, Jeffrey R, Huber, Kimberly M, Scolnick, Edward M, Holson, Edward B, Wagner, Florence F, Bear, Mark F

“…Fragile X syndrome is caused by gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates…”
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Eccentric cycling emphasising a low cardiopulmonary demand increases leg strength equivalent to workload matched concentric cycling in middle age sedentary males by Lewis, Michael C., Peoples, Gregory E., Groeller, Herbert, Brown, Marc A.

“…This study determined if eccentric endurance cycling, eliciting a low cardiovascular demand, could stimulate muscle strength adaptations in sedentary…”
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