Search Results - "LEWIS, Lynley K"

Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals by Lassé, Moritz, Pilbrow, Anna P., Kleffmann, Torsten, Andersson Överström, Elin, von Zychlinski, Anne, Frampton, Christopher M. A., Poppe, Katrina K., Troughton, Richard W., Lewis, Lynley K., Prickett, Timothy C. R., Pemberton, Christopher J., Richards, Arthur M., Cameron, Vicky A.

“…To identify circulating proteins predictive of acute cardiovascular disease events in the general population, we performed a proteomic screen in plasma from…”
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Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations by Wu, Zhenqiang, Pilbrow, Anna P., Liew, Oi Wah, Chong, Jenny P.C., Sluyter, John, Lewis, Lynley K., Lasse, Moritz, Frampton, Chris M., Jackson, Rod, Poppe, Katrina, Camargo, Carlos Arturo, Cameron, Vicky A., Scragg, Robert, Richards, A. Mark

“…Plasma cardiac markers may assist in prediction of incident cardiovascular disease. The incremental value of cardiac Troponins (T and I) and NT-proBNP added to…”
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Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system by Ali, Mahmoud Alhaj, Adem, Abdu, Chandranath, Irwin S, Benedict, Sheela, Pathan, Javed Y, Nagelkerke, Nicolas, Nyberg, Fred, Lewis, Lynley K, Yandle, Tim G, Nicholls, Gary M, Frampton, Chris M, Kazzam, Elsadig

“…Our objectives were to compare the levels of circulating electrolytes, hormones, and renal function during 20 days of dehydration in camels versus the level in…”
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ANP and BNP responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system by Adem, Abdu, Al Haj, Mahmoud, Benedict, Sheela, Yasin, Javed, Nagelkerke, Nicolas, Nyberg, Fred, Yandle, Tim G, Frampton, Chris M, Lewis, Lynley K, Nicholls, M Gary, Kazzam, Elsadig

“…The objectives of this study were to investigate and compare the responses of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in the…”
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Assays Specific for BNP1-32 and NT-proBNP Exhibit a Similar Performance to Two Widely Used Assays in the Diagnosis of Heart Failure by Lewis, Lynley K, Raudsepp, Sara D, Whitlow, Joanna C, Appleby, Sarah, Pemberton, Christopher J, Yandle, Timothy G, Mark Richards, A

“…BACKGROUNDSecretion of cardioprotective B-type natriuretic peptide 1-32 (BNP1-32) is increased proportionately with cardiac dysfunction, but its measurement in…”
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ProBNP That Is Not Glycosylated at Threonine 71 Is Decreased with Obesity in Patients with Heart Failure by Lewis, Lynley K, Raudsepp, Sara D, Prickett, Timothy C R, Yandle, Timothy G, Doughty, Robert N, Frampton, Christopher M, Pemberton, Christopher J, Richards, A Mark

“…Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Plasma concentrations of B-type natriuretic peptide (BNP) or its amino terminal…”
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Development of a BNP1-32 Immunoassay That Does Not Cross-React with proBNP by Lewis, Lynley K, Raudsepp, Sara D, Yandle, Tim G, Prickett, Timothy C, Richards, A Mark

“…Plasma B-type natriuretic peptide (BNP) concentration reflects cardiac dysfunction and assists in determining the diagnosis and prognosis of heart failure…”
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Endogenous Ouabain Is Not Ouabain by Lewis, Lynley K, Yandle, Timothy G, Hilton, Philip J, Jensen, Berit P, Begg, Evan J, Nicholls, M Gary

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Hemodynamic, Hormone, and Urinary Effects of Adrenomedullin Infusion in Essential Hypertension by Troughton, Richard W, Lewis, Lynley K, Yandle, Timothy G, Richards, A Mark, Nicholls, M Gary

“…We examined the effects of the vasodilator peptide adrenomedullin (AM) infused intravenously into subjects with essential hypertension. Eight men 39 to 58…”
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Adrenomedullin(1–52) measured in human plasma by radioimmunoassay: plasma concentration, adsorption, and storage by Lewis, Lynley K, Smith, Mary W, Yandle, Timothy G, Richards, A. Mark, Nicholls, M. Gary

“…We describe a specific and sensitive RIA for human adrenomedullin (AM)(1-52). The detection limit and the concentration required for 50% inhibition of binding…”
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Prolonged Urocortin 2 Administration in Experimental Heart Failure: Sustained Hemodynamic, Endocrine, and Renal Effects by Rademaker, Miriam T, Charles, Christopher J, Ellmers, Leigh J, Lewis, Lynley K, Nicholls, M Gary, Richards, A Mark

“…Although acute administration of urocortin 2 has beneficial actions in heart failure, the integrated hemodynamic, hormonal, and renal effects of sustained…”
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Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? by NICHOLLS, M. Gary, LEWIS, Lynley K, YANDLE, Tim G, LORD, Gwyn, MCKINNON, William, HILTON, Philip J

“…Substantial evidence points to the presence in human plasma of an inhibitor of the sodium/potassium pump which plays a central role in the pathophysiology of…”
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ProBNP processing is decreased by obesity in patients with heart failure by Lewis, Lynley K, Raudsepp, Sara D, Prickett, Tim C R, Yandle, Tim G, Pemberton, Chris J, Richards, A Mark

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B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: evidence for degradation before secretion by Mahagamasekera, Patalee G, Ruygrok, Peter N, Palmer, Suetonia C, Richards, A Mark, Ansell, Gareth S, Nicholls, M Gary, Pemberton, Christopher J, Lewis, Lynley K, Yandle, Timothy G

“…The B-type natriuretic peptides (BNP and N-terminal pro-BNP) are secreted by the heart and, in the case of BNP, serve to maintain circulatory homeostasis…”
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Generation and characterization of a mouse model of the metabolic syndrome: apolipoprotein E and aromatase double knockout mice by Scott, Nicola J A, Cameron, Vicky A, Raudsepp, Sara, Lewis, Lynley K, Simpson, Evan R, Richards, A Mark, Ellmers, Leigh J

“…The aim of this study was to create a comprehensive mouse model of the metabolic syndrome by crossing aromatase-deficient (ArKO) mice with apolipoprotein…”
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Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure by Rademaker, Miriam T, Charles, Chris J, Cooper, Garth J S, Coy, David H, Espiner, Eric A, Lewis, Lynley K, Nicholls, M Gary, Richards, A Mark

“…Advances in the treatment of heart failure may require manipulation of neurohumoral responses to cardiac impairment in addition to the established strategy of…”
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Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in man by Nicholls, M.Gary, Lainchbury, John G, Lewis, Lynley K, McGregor, David O, Richards, A.Mark, Troughton, Richard W, Yandle, Timothy G

“…Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively…”
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Adrenomedullin in Heart Failure by NICHOLLS, M. Gary, CHARLES, Christopher J., LAINCHBURY, John G., LEWIS, Lynley K., RADEMAKER, Miriam T., RICHARDS, A. Mark, YANDLE, Timothy G.

“…Patients with heart failure have frequently been reported to show elevated levels of plasma adrenomedullin. These levels generally correlate with severity of…”
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Interference by o-phenanthroline in the radioimmunoassay of angiotensin II in small volume blood samples by Braithwaite, Joy E., Yandle, Tim G., Nicholls, M. Gary, Lewis, Lynley K.

“…To investigate the ratio of enzyme inhibitor volume to blood volume in angiotensin II (Ang II) blood collection tubes. Whole blood was mixed with known volumes…”
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Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA by Lewis, Lynley K., Raudsepp, Sara D., Yandle, Timothy G., Frampton, Christopher M., Palmer, Suetonia C., Troughton, Richard W., Richards, A. Mark

“…The aim of this study was to evaluate a Milliplex NTproBNP immunoassay and to compare its performance with the Roche Elecsys assay and an in house NTproBNP…”
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