Search Results - "LEWIS, Jason S"

Radiotheranostics: a roadmap for future development by Herrmann, Ken, Schwaiger, Markus, Lewis, Jason S, Solomon, Stephen B, McNeil, Barbara J, Baumann, Michael, Gambhir, Sanjiv S, Hricak, Hedvig, Weissleder, Ralph

“…Radiotheranostics, injectable radiopharmaceuticals with antitumour effects, have seen rapid development over the past decade. Although some formulations are…”
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Click Chemistry and Radiochemistry: The First 10 Years by Meyer, Jan-Philip, Adumeau, Pierre, Lewis, Jason S, Zeglis, Brian M

“…The advent of click chemistry has had a profound influence on almost all branches of chemical science. This is particularly true of radiochemistry and the…”
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Standardized methods for the production of high specific-activity zirconium-89 by Holland, Jason P, Sheh, Yiauchung, Lewis, Jason S

“…Abstract Zirconium-89 is an attractive metallo-radionuclide for use in immuno-PET due to favorable decay characteristics. Standardized methods for the routine…”
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Targeted Brain Tumor Radiotherapy Using an Auger Emitter by Pirovano, Giacomo, Jannetti, Stephen A, Carter, Lukas M, Sadique, Ahmad, Kossatz, Susanne, Guru, Navjot, Demétrio De Souza França, Paula, Maeda, Masatomo, Zeglis, Brian M, Lewis, Jason S, Humm, John L, Reiner, Thomas

“…Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity…”
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Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy by Pereira, Patrícia M. R., Sharma, Sai Kiran, Carter, Lukas M., Edwards, Kimberly J., Pourat, Jacob, Ragupathi, Ashwin, Janjigian, Yelena Y., Durack, Jeremy C., Lewis, Jason S.

“…Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab…”
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Applications of pHLIP Technology for Cancer Imaging and Therapy by Wyatt, Linden C, Lewis, Jason S, Andreev, Oleg A, Reshetnyak, Yana K, Engelman, Donald M

“…Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as…”
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The Future of Nuclear Medicine, Molecular Imaging, and Theranostics by Weber, Wolfgang A, Czernin, Johannes, Anderson, Carolyn J, Badawi, Ramsey D, Barthel, Henryk, Bengel, Frank, Bodei, Lisa, Buvat, Irène, DiCarli, Marcelo, Graham, Michael M, Grimm, Jan, Herrmann, Ken, Kostakoglu, Lale, Lewis, Jason S, Mankoff, David A, Peterson, Todd E, Schelbert, Heinrich, Schöder, Heiko, Siegel, Barry A, Strauss, H William

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Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy by Pérez-Medina, Carlos, Abdel-Atti, Dalya, Tang, Jun, Zhao, Yiming, Fayad, Zahi A., Lewis, Jason S., Mulder, Willem J. M., Reiner, Thomas

“…The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite…”
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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer by Bosch, Ana, Li, Zhiqiang, Bergamaschi, Anna, Ellis, Haley, Toska, Eneda, Prat, Aleix, Tao, Jessica J, Spratt, Daniel E, Viola-Villegas, Nerissa T, Castel, Pau, Minuesa, Gerard, Morse, Natasha, Rodón, Jordi, Ibrahim, Yasir, Cortes, Javier, Perez-Garcia, Jose, Galvan, Patricia, Grueso, Judit, Guzman, Marta, Katzenellenbogen, John A, Kharas, Michael, Lewis, Jason S, Dickler, Maura, Serra, Violeta, Rosen, Neal, Chandarlapaty, Sarat, Scaltriti, Maurizio, Baselga, José

“…Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors, and selective phosphatidylinositol…”
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Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo by Venneti, Sriram, Dunphy, Mark P, Zhang, Hanwen, Pitter, Kenneth L, Zanzonico, Patrick, Campos, Carl, Carlin, Sean D, La Rocca, Gaspare, Lyashchenko, Serge, Ploessl, Karl, Rohle, Daniel, Omuro, Antonio M, Cross, Justin R, Brennan, Cameron W, Weber, Wolfgang A, Holland, Eric C, Mellinghoff, Ingo K, Kung, Hank F, Lewis, Jason S, Thompson, Craig B

“…Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and survive. Many cancers show altered glucose metabolism, which…”
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CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma by Huang, Chun-Hao, Lujambio, Amaia, Zuber, Johannes, Tschaharganeh, Darjus F, Doran, Michael G, Evans, Michael J, Kitzing, Thomas, Zhu, Nan, de Stanchina, Elisa, Sawyers, Charles L, Armstrong, Scott A, Lewis, Jason S, Sherr, Charles J, Lowe, Scott W

“…One-year survival rates for newly diagnosed hepatocellular carcinoma (HCC) are <50%, and unresectable HCC carries a dismal prognosis owing to its…”
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Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer by Houghton, Jacob L., Zeglis, Brian M., Abdel-Atti, Dalya, Aggeler, Robert, Sawada, Ritsuko, Agnew, Brian J., Scholz, Wolfgang W., Lewis, Jason S.

“…Molecular imaging agents for preoperative positron emission tomography (PET) and near-infrared fluorescent (NIRF)-guided delineation of surgical margins could…”
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Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses by Houghton, Jacob L, Zeglis, Brian M, Abdel-Atti, Dalya, Sawada, Ritsuko, Scholz, Wolfgang W, Lewis, Jason S

“…5B1 is a fully human, monoclonal antibody that has shown promise for the PET imaging of cancers expressing carbohydrate antigen 19.9 (CA19.9)--a carbohydrate…”
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Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers by Rao, Yi, Samuels, Zachary, Carter, Lukas M, Monette, Sebastien, Panikar, Sandeep Surendra, Pereira, Patricia M R, Lewis, Jason S

“…Human epidermal growth factor receptor 2 (HER2) is overexpressed in various cancer types. HER2-targeting trastuzumab plus chemotherapy is used as first-line…”
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Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation by Spratt, Daniel E, Evans, Michael J, Davis, Brian J, Doran, Michael G, Lee, Man Xia, Shah, Neel, Wongvipat, John, Carnazza, Kathryn E, Klee, George G, Polkinghorn, William, Tindall, Donald J, Lewis, Jason S, Sawyers, Charles L

“…Clinical trials have established the benefit of androgen deprivation therapy (ADT) combined with radiotherapy in prostate cancer. ADT sensitizes prostate…”
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Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry by Zeglis, Brian M, Davis, Charles B, Aggeler, Robert, Kang, Hee Chol, Chen, Aimei, Agnew, Brian J, Lewis, Jason S

“…An enzyme- and click chemistry-mediated methodology for the site-selective radiolabeling of antibodies on the heavy chain glycans has been developed and…”
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Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer by Sharma, Sai Kiran, Pourat, Jacob, Abdel-Atti, Dalya, Carlin, Sean D, Piersigilli, Alessandra, Bankovich, Alexander J, Gardner, Eric E, Hamdy, Omar, Isse, Kumiko, Bheddah, Sheila, Sandoval, Joseph, Cunanan, Kristen M, Johansen, Eric B, Allaj, Viola, Sisodiya, Vikram, Liu, David, Zeglis, Brian M, Rudin, Charles M, Dylla, Scott J, Poirier, John T, Lewis, Jason S

“…The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell lung cancer (SCLC) and high-grade neuroendocrine carcinomas…”
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Bioorthogonal Masking of Circulating Antibody–TCO Groups Using Tetrazine-Functionalized Dextran Polymers by Meyer, Jan-Philip, Tully, Kathryn M, Jackson, James, Dilling, Thomas R, Reiner, Thomas, Lewis, Jason S

“…Pretargeting strategies have gained popularity for the in vivo imaging and therapy of cancer by combining antibodies with small molecule radioligands. In vivo…”
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Paradigms for Precision Medicine in Epichaperome Cancer Therapy by Pillarsetty, Nagavarakishore, Jhaveri, Komal, Taldone, Tony, Caldas-Lopes, Eloisi, Punzalan, Blesida, Joshi, Suhasini, Bolaender, Alexander, Uddin, Mohammad M., Rodina, Anna, Yan, Pengrong, Ku, Anson, Ku, Thomas, Shah, Smit K., Lyashchenko, Serge, Burnazi, Eva, Wang, Tai, Lecomte, Nicolas, Janjigian, Yelena, Younes, Anas, Batlevi, Connie W., Guzman, Monica L., Roboz, Gail J., Koziorowski, Jacek, Zanzonico, Pat, Alpaugh, Mary L., Corben, Adriana, Modi, Shanu, Norton, Larry, Larson, Steven M., Lewis, Jason S., Chiosis, Gabriela, Gerecitano, John F., Dunphy, Mark P.S.

“…Alterations in protein-protein interaction networks are at the core of malignant transformation but have yet to be translated into appropriate diagnostic…”
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pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery by Crawford, Troy, Moshnikova, Anna, Roles, Sean, Weerakkody, Dhammika, DuPont, Michael, Carter, Lukas M., Shen, John, Engelman, Donald M., Lewis, Jason S., Andreev, Oleg A., Reshetnyak, Yana K.

“…Fluorescence imaging has seen enduring use in blood flow visualization and is now finding a new range of applications in image-guided surgery. In this paper,…”
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