Search Results - "LEWIS, J. G"

The role of high‐field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward by Lehericy, Stéphane, Vaillancourt, David E., Seppi, Klaus, Monchi, Oury, Rektorova, Irena, Antonini, Angelo, McKeown, Martin J., Masellis, Mario, Berg, Daniela, Rowe, James B., Lewis, Simon J. G., Williams‐Gray, Caroline H., Tessitore, Alessandro, Siebner, Hartwig R.

“…Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several…”
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The major impact of freezing of gait on quality of life in Parkinson’s disease by Walton, Courtney C., Shine, James M., Hall, Julie M., O’Callaghan, Claire, Mowszowski, Loren, Gilat, Moran, Szeto, Jennifer Y. Y., Naismith, Sharon L., Lewis, Simon J. G.

“…Freezing of gait (FOG) is a disabling motor symptom experienced by a large proportion of patients with Parkinson’s disease (PD). While it is known that FOG…”
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Circadian rhythm and sleep alterations in older people with lifetime depression: a case-control study by Hoyos, Camilla M, Gordon, Christopher, Terpening, Zoe, Norrie, Louisa, Lewis, Simon J G, Hickie, Ian B, Naismith, Sharon L

“…Depression is common in older people and is associated with underlying brain change increasing the risk of dementia. Sleep disturbance is frequently reported…”
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Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting by Youssef, Priscilla, Hughes, Laura, Kim, Woojin S., Halliday, Glenda M., Lewis, Simon J. G., Cooper, Antony, Dzamko, Nicolas

“…Objective biomarkers for Parkinson’s Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and…”
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Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load by Shine, James M, Matar, Elie, Ward, Philip B, Bolitho, Samuel J, Pearson, Mark, Naismith, Sharon L, Lewis, Simon J G

“…Freezing of gait is a devastating symptom of Parkinson's disease (PD) that is exacerbated by the processing of cognitive information whilst walking. To date,…”
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Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α‑Synuclein Autoantibodies in Human Plasma by Ge, Peng, Yang, Mu, Bouchard, Jacob L, Dzamko, Nicolas, Lewis, Simon J. G, Halliday, Glenda M, Doran, Todd M

“…The misfolding and subsequent aggregation of amyloidogenic proteins is a classic pathological hallmark of neurodegenerative diseases. Aggregates of the…”
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Facial width-to-height ratio predicts achievement drive in US presidents by Lewis, G.J., Lefevre, C.E., Bates, T.C.

“…► We examined facial width-to-height ratio (fWHR) and character traits in US presidents. ► We found a significant association between achievement drive and…”
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Dopamine Release in Dissociable Striatal Subregions Predicts the Different Effects of Oral Methylphenidate on Reversal Learning and Spatial Working Memory by Clatworthy, Philip L, Lewis, Simon J. G, Brichard, Laurent, Hong, Young T, Izquierdo, David, Clark, Luke, Cools, Roshan, Aigbirhio, Franklin I, Baron, Jean-Claude, Fryer, Timothy D, Robbins, Trevor W

“…Previous data suggest that methylphenidate can have variable effects on different cognitive tasks both within and between individuals. This is thought to be…”
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L-DOPA disrupts activity in the nucleus accumbens during reversal learning in parkinson's disease by COOLS, Roshan, LEWIS, Simon J. G, CLARK, Luke, BARKER, Roger A, ROBBINS, Trevor W

“…Evidence indicates that dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used…”
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Freezing of gait: understanding the complexity of an enigmatic phenomenon by Weiss, Daniel, Schoellmann, Anna, Fox, Michael D, Bohnen, Nicolaas I, Factor, Stewart A, Nieuwboer, Alice, Hallett, Mark, Lewis, Simon J G

“…Diverse but complementary methodologies are required to uncover the complex determinants and pathophysiology of freezing of gait. To develop future therapeutic…”
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Septic Shock and Sepsis: A Comparison of Total and Free Plasma Cortisol Levels by Ho, J. T., Al-Musalhi, H., Chapman, M. J., Quach, T., Thomas, P. D., Bagley, C. J., Lewis, J. G., Torpy, D. J.

“…Context: Severe systemic infection leads to hypercortisolism. Reduced cortisol binding proteins may accentuate the free cortisol elevations seen in systemic…”
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The role of dysfunctional attentional control networks in visual misperceptions in Parkinson's disease by Shine, James M., Halliday, Glenda M., Gilat, Moran, Matar, Elie, Bolitho, Samuel J., Carlos, Maria, Naismith, Sharon L., Lewis, Simon J.G.

“…Visual misperceptions and hallucinations represent a problematic symptom of Parkinson's disease. The pathophysiological mechanisms underlying these symptoms…”
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Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework by Matar, Elie, Shine, James M, Halliday, Glenda M, Lewis, Simon J G

“…Fluctuating cognition is a complex and disabling symptom that is seen most frequently in the context of Lewy body dementias encompassing dementia with Lewy…”
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Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry by Lewis, Simon J. G, Dove, Anja, Robbins, Trevor W, Barker, Roger A, Owen, Adrian M

“…Studies in patients with Parkinson's disease (PD) suggest that the characteristic motor symptoms of the disorder are frequently accompanied by impairments in…”
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The functional network signature of heterogeneity in freezing of gait by Ehgoetz Martens, Kaylena A, Hall, Julie M, Georgiades, Matthew J, Gilat, Moran, Walton, Courtney C, Matar, Elie, Lewis, Simon J G, Shine, James M

“…Freezing of gait in Parkinson's disease is a complex, heterogeneous and highly variable phenomenon. Using task-based fMRI, Ehgoetz Martens et al. show that…”
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Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease by Bolitho, Samuel J, Naismith, Sharon L, Salahuddin, Pierre, Terpening, Zoe, Grunstein, Ron R, Lewis, Simon J G

“…Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD) contribute significantly to morbidity in patients and their carers…”
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Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study by Galper, Jasmin, Mori, Giorgia, McDonald, Gordon, Ahmadi Rastegar, Diba, Pickford, Russell, Lewis, Simon J. G., Halliday, Glenda M., Kim, Woojin S., Dzamko, Nicolas

“…Identifying biological factors which contribute to the clinical progression of heterogeneous motor and non-motor phenotypes in Parkinson’s disease may help to…”
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Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations by Rodriguez-Porcel, Federico, Wyman-Chick, Kathryn A, Abdelnour Ruiz, Carla, Toledo, Jon B, Ferreira, Daniel, Urwyler, Prabitha, Weil, Rimona S, Kane, Joseph, Pilotto, Andrea, Rongve, Arvid, Boeve, Bradley, Taylor, John-Paul, McKeith, Ian, Aarsland, Dag, Lewis, Simon J G

“…The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of…”
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Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease by Cui, Cathy K., Lewis, Simon J. G.

“…Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson’s disease. In this review, we summarise the recent insights into freezing of…”
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Antisaccade errors reveal cognitive control deficits in Parkinson’s disease with freezing of gait by Walton, Courtney C., O’Callaghan, Claire, Hall, Julie M., Gilat, Moran, Mowszowski, Loren, Naismith, Sharon L., Burrell, James R., Shine, James M., Lewis, Simon J. G.

“…Freezing of gait is a poorly understood symptom of Parkinson’s disease (PD) that is commonly accompanied by executive dysfunction. This study employed an…”
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