Search Results - "LEWIS, DAVID L."

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities by Gish, Robert G., Given, Bruce D., Lai, Ching-Lung, Locarnini, Stephen A., Lau, Johnson Y.N., Lewis, David L., Schluep, Thomas

“…•Advances in understanding the natural history of hepatitis B have led to new definitions of the major phases of infection.•New phases are high replicative,…”
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Stochasticity in natural forage production affects use of urban areas by black bears: implications to management of human-bear conflicts by Baruch-Mordo, Sharon, Wilson, Kenneth R, Lewis, David L, Broderick, John, Mao, Julie S, Breck, Stewart W

“…The rapid expansion of global urban development is increasing opportunities for wildlife to forage and become dependent on anthropogenic resources. Wildlife…”
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Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection by Wooddell, Christine I, Rozema, David B, Hossbach, Markus, John, Matthias, Hamilton, Holly L, Chu, Qili, Hegge, Julia O, Klein, Jason J, Wakefield, Darren H, Oropeza, Claudia E, Deckert, Jochen, Roehl, Ingo, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Vornlocher, Hans-Peter, McLachlan, Alan, Lewis, David L

“…RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than…”
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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes by Rozema, David B, Lewis, David L, Wakefield, Darren H, Wong, So C, Klein, Jason J, Roesch, Paula L, Bertin, Stephanie L, Reppen, Tom W, Chu, Qili, Blokhin, Andrei V, Hagstrom, James E, Wolff, Jon A

“…Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a…”
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Individual and population fitness consequences associated with large carnivore use of residential development by Johnson, Heather E., Lewis, David L., Breck, Stewart W.

“…Large carnivores are negotiating increasingly developed landscapes, but little is known about how such behavioral plasticity influences their demographic rates…”
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Targeted in vivo delivery of siRNA and an endosome-releasing agent to hepatocytes by Sebestyén, Magdolna G, Wong, So C, Trubetskoy, Vladimir, Lewis, David L, Wooddell, Christine I

“…The discoveries of RNA interference (RNAi) and short interfering RNAs (siRNAs) have provided the opportunity to treat diseases in a fundamentally new way: by…”
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Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers by Schluep, Thomas, Lickliter, Jason, Hamilton, James, Lewis, David L., Lai, Ching‐Lung, Lau, Johnson YN, Locarnini, Stephen A., Gish, Robert G., Given, Bruce D.

“…ARC‐520 Injection, an RNA interference drug for the treatment of hepatitis B that targets cccDNA‐derived viral mRNA transcripts with high specificity,…”
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A Facile Nonviral Method for Delivering Genes and siRNAs to Skeletal Muscle of Mammalian Limbs by Hagstrom, James E, Hegge, Julia, Zhang, Guofeng, Noble, Mark, Budker, Vladimir, Lewis, David L, Herweijer, Hans, Wolff, Jon A

“…Delivery is increasingly being recognized as the critical hurdle holding back the tremendous promise of nucleic acid-based therapies that include gene therapy…”
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Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice by De Souza, Angus T, Dai, Xudong, Spencer, Andrew G, Reppen, Tom, Menzie, Ann, Roesch, Paula L, He, Yudong, Caguyong, Michelle J, Bloomer, Sherri, Herweijer, Hans, Wolff, Jon A, Hagstrom, James E, Lewis, David L, Linsley, Peter S, Ulrich, Roger G

“…RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to…”
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Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules by Rozema, David B, Ekena, Kirk, Lewis, David L, Loomis, Aaron G, Wolff, Jon A

“…Endosomolysis, a critical barrier to efficient delivery of macromolecules such as nucleic acids, has been breached using a novel approach:  endosomolysis by…”
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RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg by Wooddell, Christine I, Yuen, Man-Fung, Chan, Henry Lik-Yuen, Gish, Robert G, Locarnini, Stephen A, Chavez, Deborah, Ferrari, Carlo, Given, Bruce D, Hamilton, James, Kanner, Steven B, Lai, Ching-Lung, Lau, Johnson Y N, Schluep, Thomas, Xu, Zhao, Lanford, Robert E, Lewis, David L

“…Chronic hepatitis B virus (HBV) infection is a major health concern worldwide, frequently leading to liver cirrhosis, liver failure, and hepatocellular…”
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King: A Biography by Lewis, David Levering

“…Acclaimed by leading historians and critics when it appeared shortly after the death of Dr. Martin Luther King Jr., this foundational biography wends through…”
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Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules by Sebestyén, Magdolna G., Budker, Vladimir G., Budker, Tatiana, Subbotin, Vladimir M., Zhang, Guofeng, Monahan, Sean D., Lewis, David L., Wong, So C., Hagstrom, James E., Wolff, Jon A.

“…Background The hydrodynamic tail vein (HTV) injection of naked plasmid DNA is a simple yet effective in vivo gene delivery method into hepatocytes. It is…”
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Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent by Gish, Robert G., Yuen, Man-Fung, Chan, Henry Lik Yuen, Given, Bruce D., Lai, Ching-Lung, Locarnini, Stephen A., Lau, Johnson Y.N., Wooddell, Christine I., Schluep, Thomas, Lewis, David L.

“…•New therapies for chronic hepatitis B are needed to achieve functional cure defined by sustained seroclearance of HBsAg.•Current drugs such as NUCs and IFN…”
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Assessing Ecological and Social Outcomes of a Bear-Proofing Experiment by JOHNSON, HEATHER E., LEWIS, DAVID L., LISCHKA, STACY A., BRECK, STEWART W.

“…Human-black bear conflicts within urban environments have been increasing throughout North America, becoming a high priority management issue. The main factor…”
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Prospective study of cross-infection from upper-GI endoscopy in a hepatitis C–prevalent population by Mikhail, Nabiel N., MD, Lewis, David L., PhD, Omar, Nabiel, MD, Taha, Hossam, MD, El-Badawy, Amal, PhD, Abdel-Mawgoud, Naglaa, PhD, Abdel-Hamid, Mohamed, MD, PhD, Strickland, George T., MD, PhD, DCMT

“…Background A high prevalence of hepatitis C (HCV) in the Egyptian Nile Delta increases the demand for upper-GI endoscopy (UGIE) and the risk of cross-infection…”
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Human development and climate affect hibernation in a large carnivore with implications for human-carnivore conflicts by Johnson, Heather E., Lewis, David L., Verzuh, Tana L., Wallace, Cody F., Much, Rebecca M., Willmarth, Lyle K., Breck, Stewart W.

“…1. Expanding human development and climate change are dramatically altering habitat conditions for wildlife. While the initial response of wildlife to changing…”
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Body Dysmorphic Disorder by Ende, Kevin H., MD, Lewis, David L., MD, Kabaker, Sheldon S., MD

“…Body dysmorphic disorder occurs in 1% of the general population, rising to 6 to 16 times higher in patients presenting to plastic surgery clinics. This article…”
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Monopoly on Wheels: Henry Ford and the Selden Automobile Patent by Greenleaf, William, Lewis, David L

“…Examines the eight-year legal fight to overturn the Selden automobile patent in the early days of the American auto industry…”
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Long-term RNA interference from optimized siRNA expression constructs in adult mice by Wooddell, Christine I., Van Hout, Cristopher V., Reppen, Thomas, Lewis, David L., Herweijer, Hans

“…DNA constructs for small interfering RNA (siRNA) expression in mammalian cells have the potential for longer-term target gene knockdown than synthetic siRNAs…”
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