Search Results - "LEWINTER, Martin M"

Tachycardia-Induced Diastolic Dysfunction and Resting Tone in Myocardium From Patients With a Normal Ejection Fraction by Selby, Donald E., PhD, Palmer, Bradley M., PhD, LeWinter, Martin M., MD, Meyer, Markus, MD

“…Objectives The purpose of this study is to evaluate tachycardia-induced relaxation abnormalities in myocardium from patients with a normal ejection fraction…”
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Sustained Pericarditis Recurrence Risk Reduction With Long-Term Rilonacept by Imazio, Massimo, Klein, Allan L, Brucato, Antonio, Abbate, Antonio, Arad, Michael, Cremer, Paul C, Insalaco, Antonella, LeWinter, Martin M, Lewis, Basil S, Lin, David, Luis, Sushil A, Nicholls, Stephen J, Sutej, Paul, Wasserstrum, Yishay, Clair, JoAnn, Agarwal, Indra, Wang, Sheldon, Paolini, John F

“…Rilonacept, a once-weekly interleukin-1 alpha and beta cytokine trap, reduced pericarditis recurrence in the phase 3 study, RHAPSODY (Rilonacept Inhibition of…”
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Pro‐Inflammatory Biomarkers in Stable Versus Acutely Decompensated Heart Failure With Preserved Ejection Fraction by Abernethy, Abraham, Raza, Sadi, Sun, Jie‐Lena, Anstrom, Kevin J., Tracy, Russell, Steiner, Johannes, VanBuren, Peter, LeWinter, Martin M.

“…Background Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction (HFpEF). In this study we tested the…”
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Acute Pericarditis by LeWinter, Martin M

“…Acute pericarditis in the United States is usually idiopathic and presumed to be viral. A history and laboratory tests, a chest radiograph, and an…”
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Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction by Bishu, Kalkidan, MD, Deswal, Anita, MD, MPH, Chen, Horng H., MD, LeWinter, Martin M., MD, Lewis, Gregory D., MD, Semigran, Marc J., MD, Borlaug, Barry A., MD, McNulty, Steven, MS, Hernandez, Adrian F., MD, Braunwald, Eugene, MD, Redfield, Margaret M., MD

“…Background Acute decompensated heart failure (ADHF) occurs with preserved (heart failure with preserved ejection fraction [HFpEF] ≥50%) or reduced (heart…”
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Relationship of exercise capacity and left ventricular dimensions in patients with a normal ejection fraction. An exploratory study by Meyer, Markus, McEntee, Rachel K, Nyotowidjojo, Iwan, Chu, Guoxiang, LeWinter, Martin M

“…Extreme endurance exercise is known to be associated with an enlargement of the left ventricular (LV) chamber, whereas inactivity results in inverse changes…”
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Effect of Resistance Training on Physical Disability in Chronic Heart Failure by SAVAGE, Patrick A, SHAW, Anthony O, MILLER, Mark S, VANBUREN, Peter, LEWINTER, Martin M, ADES, Philip A, TOTH, Michael J

“…Patients with chronic heart failure (CHF) report difficulty performing activities of daily living. To our knowledge, however, no study has directly measured…”
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Health-related quality of life in patients with recurrent pericarditis: results from a phase 2 study of rilonacept by Lin, David, Klein, Allan, Cella, David, Beutler, Anna, Fang, Fang, Magestro, Matt, Cremer, Paul, LeWinter, Martin M, Luis, Sushil Allen, Abbate, Antonio, Ertel, Andrew, Litcher-Kelly, Leighann, Klooster, Brittany, Paolini, John F

“…Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an…”
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Interleukin‐1 Trap Rilonacept Improved Health‐Related Quality of Life and Sleep in Patients With Recurrent Pericarditis: Results From the Phase 3 Clinical Trial RHAPSODY by Brucato, Antonio, Lim‐Watson, Michelle Z., Klein, Allan, Imazio, Massimo, Cella, David, Cremer, Paul, LeWinter, Martin M., Luis, Sushil Allen, Lin, David, Lotan, Dor, Pancrazi, Massimo, Trotta, Lucia, Klooster, Brittany, Litcher‐Kelly, Leighann, Zou, Liangxing, Magestro, Matt, Wheeler, Alistair, Paolini, John F., Abbate, Antonio, Abo‐Auda, Wael, Akhtar, Asif, Arad, Michael, Atar, Shaul, Baibhav, Bipul, Bhalla, Karan, Brucato, Antonio, Collins, Sean, Colquhoun, David, Cremer, Paul, Cross, David, Dwivedi, Girish, Eisen, Alon, Freedberg, Nahum, Fuchs, Shmuel, Gaddam, Eliyazar, Gattorno, Marco, Gelfand, Eli, Grena, Paul, Halabi, Majdi, Harris, David, Imazio, Massimo, Insalaco, Antonella, Karim, Amin, Klein, Allan, Knowlton, Kirk, Kontzias, Apostolos, Kornberg, Robert, Latif, Faisal, Leibowitz, David, LeWinter, Martin, Lin, David, Lotan, Dor

“…Background Recurrent pericarditis is characterized by painful flares and inflammation, which negatively impact health‐related quality of life. RHAPSODY…”
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Cardiorenal Rescue Study in Acute Decompensated Heart Failure: Rationale and Design of CARRESS-HF, for the Heart Failure Clinical Research Network by Bart, Bradley A., MD, Goldsmith, Steven R., MD, Lee, Kerry L., PhD, Redfield, Margaret M., MD, Felker, G. Michael, MD, O’Connor, Christopher M., MD, Chen, Horng H., MD, Rouleau, Jean L., MD, Givertz, Michael M., MD, Semigran, Marc j., MD, Mann, Douglas, MD, Deswal, Anita, MD, Bull, David A., MD, Lewinter, Martin M., MD, Braunwald, Eugene, MD

“…Abstract Background Worsening renal function is common among patients hospitalized for acute decompensated heart failure (ADHF). When this occurs, subsequent…”
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Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use? by Meyer, Markus, LeWinter, Martin M

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Colchicine and beyond: New options for the treatment of pericarditis by LeWinter, Martin M., MD

“…[...]about 10-30% of patients suffer recurrences [2-4,6], which can be debilitating despite re-treatment with a NSAID and/or addition of a corticosteroid…”
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MY APPROACH to patients with acute pericarditis by LeWinter, Martin M., MD, FACC, FAHA

“…[...]determine if there are significant complications. [...]begin treatment. In a recently published randomized clinical trial, colchicine improved symptomatic…”
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Determinants of Passive Myocardial Stiffness Along the Spectrum of Aortic Stenosis by LeWinter, Martin M., MD

“…Corresponding Author…”
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Cardiac Titin: A Multifunctional Giant by LEWINTER, Martin M, GRANZIER, Henk

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Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity by Wang, Yuan, Tanner, Bertrand C.W, Lombardo, Andrew T, Tremble, Sarah M, Maughan, David W, VanBuren, Peter, LeWinter, Martin M, Robbins, Jeffrey, Palmer, Bradley M

“…Abstract We measured myosin crossbridge detachment rate and the rates of MgADP release and MgATP binding in mouse and rat myocardial strips bearing one of the…”
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Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function by TOTH, Michael J, WARD, Kimberly, VAN DER VELDEN, Jos, MILLER, Mark S, VANBUREN, Peter, LEWINTER, Martin M, ADES, Philip A

“…Patients with chronic heart failure (HF) frequently lose muscle mass and function during the course of the disease. A reduction in anabolic stimuli to the…”
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Heart Rate-Induced Myocardial Ca2+ Retention and Left Ventricular Volume Loss in Patients With Heart Failure With Preserved Ejection Fraction by Silverman, Daniel N, Rambod, Mehdi, Lustgarten, Daniel L, Lobel, Robert, LeWinter, Martin M, Meyer, Markus

“…Background Increases in heart rate are thought to result in incomplete left ventricular (LV) relaxation and elevated filling pressures in patients with heart…”
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Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation by Toth, Michael J, LeWinter, Martin M, Ades, Philip A, Matthews, Dwight E

“…Patients with chronic HF (heart failure) experience muscle atrophy during the course of the disease. The mechanisms underlying muscle atrophy in HF, however,…”
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Pericardial Effusion by Azarbal, Amir, LeWinter, Martin M.

“…The normal pericardial sac contains up to 50 mL of fluid, which consists of a plasma ultrafiltrate. Anything greater constitutes a pathologic effusion. The…”
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