Search Results - "LEVY, Ofer"

Innate immunity of the newborn: basic mechanisms and clinical correlates by Levy, Ofer

“…The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses…”
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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny by Kollmann, Tobias R., Kampmann, Beate, Mazmanian, Sarkis K., Marchant, Arnaud, Levy, Ofer

“…Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in…”
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Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly by Kollmann, Tobias R., Levy, Ofer, Montgomery, Ruth R., Goriely, Stanislas

“…Given the "inborn" nature of the innate immune system, it is surprising to find that innate immune function does in fact change with age. Similar patterns of…”
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Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review by Nanishi, Etsuro, Levy, Ofer, Ozonoff, Al

“…The U.S. Centers for Disease Control and Prevention (CDC) and other health agencies have recently recommended a booster dose of COVID-19 vaccines for specific…”
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Harnessing the beneficial heterologous effects of vaccination by Goodridge, Helen S., Ahmed, S. Sohail, Curtis, Nigel, Kollmann, Tobias R., Levy, Ofer, Netea, Mihai G., Pollard, Andrew J., van Crevel, Reinout, Wilson, Christopher B.

“…Clinical evidence, including results from randomized controlled clinical trials, strongly suggests that certain live vaccines can reduce all-cause mortality,…”
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Infection-induced inflammation and cerebral injury in preterm infants by Strunk, Tobias, Dr, Inder, Terrie, MD, Wang, Xiaoyang, PhD, Burgner, David, Prof, Mallard, Carina, Prof, Levy, Ofer, PhD

“…Summary Preterm birth and infectious diseases are the most common causes of neonatal and early childhood deaths worldwide. The rates of preterm birth have…”
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Developmental Biology of the Innate Immune Response: Implications for Neonatal and Infant Vaccine Development by Philbin, Victoria Jane, Levy, Ofer

“…Molecular characterization of mechanisms by which human pattern recognition receptors (PRRs) detect danger signals has greatly expanded our understanding of…”
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Neonatal Immunization: Rationale, Current State, and Future Prospects by Whittaker, Elizabeth, Goldblatt, David, McIntyre, Peter, Levy, Ofer

“…Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and…”
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The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity by Stanietsky, Noa, Simic, Hrvoje, Arapovic, Jurica, Toporik, Amir, Levy, Ofer, Novik, Amit, Levine, Zurit, Beiman, Meirav, Dassa, Liat, Achdout, Hagit, Stern-Ginossar, Noam, Tsukerman, Pinhas, Jonjic, Stipan, Mandelboim, Ofer

“…NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are…”
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Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes by Levy, Ofer

“…Phagocytic leukocytes are a central cellular element of innate‐immune defense in mammals. Over the past few decades, substantial progress has been made in…”
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Development of newborn and infant vaccines by Sanchez-Schmitz, Guzman, Levy, Ofer

“…Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been…”
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The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice by Sharma, Pankaj, Levy, Ofer, Dowling, David J

“…Intranasal mucosal vaccines are an attractive approach to induce protective mucosal immune responses. Activation of lung antigen presenting cells (APCs), a…”
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Safety and efficacy of neonatal vaccination by Demirjian, Alicia, Levy, Ofer

“…Newborns have an immature immune system that renders them at high risk for infection while simultaneously reducing responses to most vaccines, thereby posing…”
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Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses by Dowling, David J., PhD, Scott, Evan A., PhD, Scheid, Annette, MD, Bergelson, Ilana, BSc, Joshi, Sweta, PhD, Pietrasanta, Carlo, MD, Brightman, Spencer, BA, Sanchez-Schmitz, Guzman, MSc, PhD, Van Haren, Simon D., PhD, Ninković, Jana, PhD, Kats, Dina, BSc, Guiducci, Cristiana, PhD, de Titta, Alexandre, PhD, Bonner, Daniel K., PhD, Hirosue, Sachiko, PhD, Swartz, Melody A., PhD, Hubbell, Jeffrey A., PhD, Levy, Ofer, MD, PhD

“…Background Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells…”
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Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization by van Haren, Simon D, Dowling, David J, Foppen, Willemina, Christensen, Dennis, Andersen, Peter, Reed, Steven G, Hershberg, Robert M, Baden, Lindsey R, Levy, Ofer

“…Due to functionally distinct cell-mediated immunity, newborns and infants are highly susceptible to infection with intracellular pathogens. Indeed, neonatal…”
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Editorial: Precision vaccinology for infectious diseases by Rahman, Mahbuba, Adeli, Mehdi, Schellhorn, Herb E, Jithesh, Puthen Veettil, Levy, Ofer

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Bilateral reverse total shoulder arthroplasty—functional outcome and activities of daily living by Levy, Ofer, MD, MCh(Orth), FRCS, Walecka, Joanna, MD, Arealis, George, MD, Tsvieli, Oren, MD, Della Rotonda, Giuseppe, MD, Abraham, Ruben, FRCA, Polyzois, Ioannis, MD, Jurkowski, Zac, BSc, Atoun, Ehud, MD

“…Background Reverse total shoulder arthroplasty (rTSA) has gained popularity in recent years, providing good shoulder elevation, yet less predictable rotations…”
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity by Borriello, Francesco, Poli, Valentina, Shrock, Ellen, Spreafico, Roberto, Liu, Xin, Pishesha, Novalia, Carpenet, Claire, Chou, Janet, Di Gioia, Marco, McGrath, Marisa E., Dillen, Carly A., Barrett, Nora A., Lacanfora, Lucrezia, Franco, Marcella E., Marongiu, Laura, Iwakura, Yoichiro, Pucci, Ferdinando, Kruppa, Michael D., Ma, Zuchao, Lowman, Douglas W., Ensley, Harry E., Nanishi, Etsuro, Saito, Yoshine, O’Meara, Timothy R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Dowling, David J., Frieman, Matthew, Elledge, Stephen J., Levy, Ofer, Irvine, Darrell J., Ploegh, Hidde L., Williams, David L., Zanoni, Ivan

“…Activation of the innate immune system via pattern recognition receptors (PRRs) is key to generate lasting adaptive immunity. PRRs detect unique chemical…”
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BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny by Angelidou, Asimenia, Diray-Arce, Joann, Conti, Maria Giulia, Smolen, Kinga K, van Haren, Simon Daniël, Dowling, David J, Husson, Robert N, Levy, Ofer

“…Vaccines have been traditionally developed with the presumption that they exert identical immunogenicity regardless of target population and that they provide…”
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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways by Philbin, Victoria J., DPhil, Dowling, David J., PhD, Gallington, Leighanne C., BSc, Cortés, Guadalupe, PhD, Tan, Zhen, MD, Suter, Eugénie E., MA, Chi, Kevin W., BA, Shuckett, Ariel, MPH, Stoler-Barak, Liat, MSc, Tomai, Mark, PhD, Miller, Richard L., PhD, Mansfield, Keith, DVM, Levy, Ofer, MD, PhD

“…Background Newborns have frequent infections and manifest impaired vaccine responses, motivating a search for neonatal vaccine adjuvants. Alum is a neonatal…”
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