Search Results - "LEVINE, Alan D"

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer by Zhang, Zhenfeng, Lee, Jae Cheol, Lin, Luping, Olivas, Victor, Au, Valerie, LaFramboise, Thomas, Abdel-Rahman, Mohamed, Wang, Xiaoqi, Levine, Alan D, Rho, Jin Kyung, Choi, Yun Jung, Choi, Chang-Min, Kim, Sang-We, Jang, Se Jin, Park, Young Soo, Kim, Woo Sung, Lee, Dae Ho, Lee, Jung-Shin, Miller, Vincent A, Arcila, Maria, Ladanyi, Marc, Moonsamy, Philicia, Sawyers, Charles, Boggon, Titus J, Ma, Patrick C, Costa, Carlota, Taron, Miquel, Rosell, Rafael, Halmos, Balazs, Bivona, Trever G

“…Trever Bivona and colleagues identify the upregulation of the AXL kinase in human non–small cell lung cancer with acquired resistance to erlotinib. Inhibition…”
Get full text

Transcription factor ISX mediates the cross talk between diet and immunity by Widjaja-Adhi, Made Airanthi K., Palczewski, Grzegorz, Dale, Kali, Knauss, Elizabeth A., Kelly, Mary E., Golczak, Marcin, Levine, Alan D., von Lintig, Johannes

“…The intestinal epithelium is a major site for the conversion of dietary β-carotene to retinaldehyde by the enzyme BCO1. The majority of retinaldehyde is…”
Get full text

Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity by Cruz-Lebrón, Angélica, Johnson, Ramona, Mazahery, Claire, Troyer, Zach, Joussef-Piña, Samira, Quiñones-Mateu, Miguel E., Strauch, Christopher M, Hazen, Stanley L., Levine, Alan D.

“…Over the past three decades the United States has experienced a devastating opioid epidemic. One of the many debilitating side effects of chronic opioid use is…”
Get full text

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells by Zhang, Zhenfeng, Kobayashi, Susumu, Borczuk, Alain C., Leidner, Rom S., LaFramboise, Thomas, Levine, Alan D., Halmos, Balazs

“…Mitogen-activated protein kinase (MAPK) pathway signaling plays an important role in the majority of non-small-cell lung cancers (NSCLCs). In a prior…”
Get full text

Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+ individuals by Chung, Charlotte Y, Alden, Stephanie L, Funderburg, Nicholas T, Fu, Pingfu, Levine, Alan D

“…Effective antiretroviral therapy (ART) dramatically reduces AIDS-related complications, yet the life expectancy of long-term ART-treated HIV-infected patients…”
Get full text

The role of CXCL12 and CCL7 chemokines in immune regulation, embryonic development, and tissue regeneration by Cheng, Julie W., Sadeghi, Zhina, Levine, Alan D., Penn, Marc S., von Recum, Horst A., Caplan, Arnold I., Hijaz, Adonis

“…•Chemokines CXCL12 and CCL7 direct chemotaxis.•CXCL12 contributes to embryonic development.•CXCL12 and CCL7 each influence stem cell recruitment following…”
Get full text

T Cell-, Interleukin-12-, and Gamma Interferon-Driven Viral Clearance in Measles Virus-Infected Brain Tissue by STUBBLEFIELD PARK, Samantha R, WIDNESS, Mi, LEVINE, Alan D, PATTERSON, Catherine E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Examining the positive effects of exercise in intubated adults in ICU: A prospective repeated measures clinical study by Winkelman, Chris, Johnson, Kimberly D., Hejal, Rana, Gordon, Nahida H., Rowbottom, James, Daly, Janis, Peereboom, Karen, Levine, Alan D.

“…Determining the optimal timing and progression of mobility exercise has the potential to affect functional recovery of critically ill adults. This study…”
Get full text

Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells by Meisch, Jeffrey P., Vogel, Ryan M., Schlatzer, Daniela M., Li, Xiaolin, Chance, Mark R., Levine, Alan D.

“…In T cells, human β‐defensin 3 induces STAT1 tyrosine phosphorylation, tyrosine phosphatase activity, and SHP‐2 nuclear accumulation, which inhibits IFN‐γ…”
Get full text

Interleukin-10 Controls the Onset of Irreversible Septic Shock by Latifi, Samir Q., O'Riordan, Mary Ann, Levine, Alan D.

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Distinct inflammatory mechanisms mediate early versus late colitis in mice by Spencer, David M., Veldman, Geertruidam M., Banerjee, Subhashis, Willis, Joseph, Levine, Alan D.

“…Progression from the acute to chronic phase of inflammatory bowel disease cannot be easily evaluated in patients and has not been characterized in animal…”
Get full text

Impact of Caveolin-Mediated Endocytosis on the Trafficking of HIV within the Colonic Barrier by Anwar, Alex, Helou, Michelle, Hervol, Jessica, Levine, Alan D

“…In the United States, most new cases of human immunodeficiency virus (HIV) belong to the at-risk group of gay and bisexual men. Developing therapies to reverse…”
Get full text

Mitochondria-derived Hydrogen Peroxide Selectively Enhances T Cell Receptor-initiated Signal Transduction by Gill, Tejpal, Levine, Alan D.

“…T cell receptor (TCR)-initiated signal transduction is reported to increase production of intracellular reactive oxygen species, such as superoxide (O2⨪) and…”
Get full text

RETRACTED: REDOX regulation of IL-13 signaling in intestinal epithelial cells: Usage of alternate pathways mediates distinct gene expression patterns by Mandal, Debasmita, Fu, Pingfu, Levine, Alan D.

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy. This article has been…”
Get full text

Chronic Methadone Use Alters the CD8 + T Cell Phenotype In Vivo and Modulates Its Responsiveness Ex Vivo to Opioid Receptor and TCR Stimuli by Mazahery, Claire, Benson, Bryan L, Cruz-Lebrón, Angélica, Levine, Alan D

“…Endogenous opioid peptides are released at sites of injury, and their cognate G protein-coupled opioid receptors (ORs) are expressed on immune cells. Although…”
Get full text

Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner by Franko, Jennifer L., Levine, Alan D.

“…Engagement of the costimulatory protein ICOS activates effector/memory T cells in tissue by enhancing TCR‐mediated proliferation and cytokine production. We…”
Get full text

Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium by Swedik, Stephanie M, Madola, Abson, Cruz, Michelle A, Llorens-Bonilla, Braulio J, Levine, Alan D

“…Tightly regulated communication between the gastrointestinal epithelium and immune cells in the underlying lamina propria is critical for immune homeostasis…”
Get full text

Impairment of regulatory T-cell function in autoimmune thyroid disease by Glick, Abigail B, Wodzinski, Alaina, Fu, Pingfu, Levine, Alan D, Wald, David N

“…Autoimmune thyroid disease (AITD) pathogenesis may result from a loss of immune tolerance to thyroid antigens. Regulatory T cells (Tregs) control immune…”
Get more information

Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers by Shukla, Sourabh, Myers, Jay T, Woods, Sarah E, Gong, Xingjian, Czapar, Anna E, Commandeur, Ulrich, Huang, Alex Y, Levine, Alan, Steinmetz, Nicole F

“…Abstract Cancer vaccines are designed to elicit an endogenous adaptive immune response that can successfully recognize and eliminate residual or recurring…”
Get full text

IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells by Goodman, Wendy A, Levine, Alan D, Massari, Jessica V, Sugiyama, Hideaki, McCormick, Thomas S, Cooper, Kevin D

“…T memory/effector cells (Tmem/eff) isolated from psoriatic patients are chronically activated and poorly suppressed by regulatory T cells (Treg). The…”
Get full text