Search Results - "LEVINE, A. Joan"

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships by Cortessis, Victoria K., Thomas, Duncan C., Levine, A. Joan, Breton, Carrie V., Mack, Thomas M., Siegmund, Kimberly D., Haile, Robert W., Laird, Peter W.

“…Changes in epigenetic marks such as DNA methylation and histone acetylation are associated with a broad range of disease traits, including cancer, asthma,…”
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Risks of Primary Extracolonic Cancers Following Colorectal Cancer in Lynch Syndrome by KOWIN, Aung, LINDOR, Noralane M, LEGGETT, Barbara, TUCKER, Katherine M, GILES, Graham G, BUCHANAN, Daniel D, CLENDENNING, Mark, ROSTY, Christophe, ARNOLD, Julie, JOAN LEVINE, A, HAILE, Robert W, GALLINGER, Steven, PYOUNG, Joanne, LE MARCHAND, Loïc, NEWCOMB, Polly A, HOPPER, John L, JENKINS, Mark A, MACRAE, Finlay A, PYOUNG, Graeme, WILLIAMSON, Elizabeth, PARRY, Susan, GOLDBLATT, Jack, LIPTON, Lara, WINSHIP, Ingrid

“…Lynch syndrome is a highly penetrant cancer predisposition syndrome caused by germline mutations in DNA mismatch repair (MMR) genes. We estimated the risks of…”
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Genome‐wide association study of circulating folate one‐carbon metabolites by Wang, Jun, Asante, Isaac, Baron, John A., Figueiredo, Jane C., Haile, Robert, Joan Levine, A., Newcomb, Polly A., Templeton, Allyson S., Schumacher, Fredrick R., Louie, Stan G., Casey, Graham, Conti, David V.

“…Experimental, observational, and clinical trials support a critical role of folate one‐carbon metabolism (FOCM) in colorectal cancer (CRC) development. In this…”
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Rare Variants in the DNA Repair Pathway and the Risk of Colorectal Cancer by Matejcic, Marco, Shaban, Hiba A, Quintana, Melanie W, Schumacher, Fredrick R, Edlund, Christopher K, Naghi, Leah, Pai, Rish K, Haile, Robert W, Levine, A Joan, Buchanan, Daniel D, Jenkins, Mark A, Figueiredo, Jane C, Rennert, Gad, Gruber, Stephen B, Li, Li, Casey, Graham, Conti, David V, Schmit, Stephanie L

“…Inherited susceptibility is an important contributor to colorectal cancer risk, and rare variants in key genes or pathways could account in part for the…”
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Molecular Characterization of MSI-H Colorectal Cancer by MLHI Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening by Poynter, Jenny N, Siegmund, Kimberly D, Weisenberger, Daniel J, Long, Tiffany I, Thibodeau, Stephen N, Lindor, Noralane, Young, Joanne, Jenkins, Mark A, Hopper, John L, Baron, John A, Buchanan, Dan, Casey, Graham, Levine, A Joan, Le Marchand, Loïc, Gallinger, Steven, Bapat, Bharati, Potter, John D, Newcomb, Polly A, Haile, Robert W, Laird, Peter W

“…Microsatellite instability (MSI) occurs in 10% to 20% of colorectal cancers (CRC) and has been attributed to both MLH1 promoter hypermethylation and germline…”
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Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa by Wallace, Kristin, Grau, Maria V, Levine, A Joan, Shen, Lanlan, Hamdan, Randala, Chen, Xinli, Gui, Jiang, Haile, Robert W, Barry, Elizabeth L, Ahnen, Dennis, McKeown-Eyssen, Gail, Baron, John A, Issa, Jean Pierre J

“…Gene-specific promoter methylation of several genes occurs in aging normal tissues and may predispose to tumorigenesis. In the present study, we investigate…”
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Global DNA Hypomethylation (LINE-1) in the Normal Colon and Lifestyle Characteristics and Dietary and Genetic Factors by FIGUEIREDO, Jane C, GRAU, Maria V, BARON, John A, ISSA, Jean-Pierre J, WALLACE, Kristin, LEVINE, A. Joan, LANLAN SHEN, HAMDAN, Randala, XINLI CHEN, BRESALIER, Robert S, MCKEOWN-EYSSEN, Gail, HAILE, Robert W

“…Background: Global loss of methylated cytosines in DNA, thought to predispose to chromosomal instability and aneuploidy, has been associated with an increased…”
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A systematic review of studies of DNA methylation in the context of a weight loss intervention by Aronica, Lucia, Levine, A Joan, Brennan, Kevin, Mi, Jeffrey, Gardner, Christopher, Haile, Robert W, Hitchins, Megan P

“…Obesity results from the interaction of genetic and environmental factors, which may involve epigenetic mechanisms such as DNA methylation (DNAm). We have…”
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Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors by Levine, A Joan, Phipps, Amanda I, Baron, John A, Buchanan, Daniel D, Ahnen, Dennis J, Cohen, Stacey A, Lindor, Noralane M, Newcomb, Polly A, Rosty, Christophe, Haile, Robert W, Laird, Peter W, Weisenberger, Daniel J

“…The CpG island methylator phenotype (CIMP) is a major molecular pathway in colorectal cancer. Approximately 25% to 60% of CIMP tumors are microsatellite…”
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Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk by Corral, Roman, Lewinger, Juan Pablo, Joshi, Amit D, Levine, A Joan, Vandenberg, David J, Haile, Robert W, Stern, Mariana C

“…Cigarette smoking, high alcohol intake, and low dietary folate levels are risk factors for colorectal adenomas. Oxidative damage caused by these three factors…”
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Genetic Variability in the MTHFR Gene and Colorectal Cancer Risk Using the Colorectal Cancer Family Registry by JOAN LEVINE, A, FIGUEIREDO, Jane C, LE MARCHAND, Loic, BARON, John A, LIMBURG, Paul J, ULRICH, Cornelia M, HAILE, Robert W, LEE, Won, POYNTER, Jenny N, CONTI, David, DUGGAN, David J, CAMPBELL, Peter T, NEWCOMB, Polly, MARTINEZ, Maria Elena, HOPPER, John L

“…Background: The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene…”
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Genetic Variation in the Vitamin D Receptor (VDR) and the Vitamin D―Binding Protein (GC) and Risk for Colorectal Cancer: Results from the Colon Cancer Family Registry by POYNTER, Jenny N, JACOBS, Elizabeth T, NEWCOMB, Polly A, POTTER, John D, JENKINS, Mark A, HOPPER, John L, DUGGAN, David J, BARON, John A, HAILE, Robert W, FIGUEIREDO, Jane C, LEE, Won H, CONTI, David V, CAMPBELL, Peter T, LEVINE, A. Joan, LIMBURG, Paul, LE MARCHAND, Loic, COTTERCHIO, Michelle

“…Epidemiologic evidence supports a role for vitamin D in colorectal cancer (CRC) risk. Variants in vitamin D-related genes might modify the association between…”
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BRCA1 and BRCA2 Mutation Carriers, Oral Contraceptive Use, and Breast Cancer Before Age 50 by HAILE, Robert W, THOMAS, Duncan C, BUYS, Saundra S, SENIE, Ruby T, ANDRULIS, Irene L, KNIGHT, Julia A, GODWIN, Andrew K, SOUTHEY, Melissa, MCCREDIE, Margaret R. E, GILES, Graham G, ANDREWS, Lesley, TUCKER, Katherine, MCGUIRE, Valerie, MIRON, Alexander, APICELLA, Carmel, TESORIERO, Andrea, BANE, Anita, PIKE, Malcolm C, INVESTIGATORS, Kconfab, FELBERG, Anna, JOHN, Esther M, MILNE, Roger L, HOPPER, John L, JENKINS, Mark A, LEVINE, A. Joan, DALY, Mary M

“…Background: Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral…”
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Vitamins B2, B6, and B12 and Risk of New Colorectal Adenomas in a Randomized Trial of Aspirin Use and Folic Acid Supplementation by Figueiredo, Jane C, Levine, A Joan, Grau, Maria V, Midttun, Oivind, Ueland, Per M, Ahnen, Dennis J, Barry, Elizabeth L, Tsang, Shirley, Munroe, David, Ali, Iqbal, Haile, Robert W, Sandler, Robert S, Baron, John A

“…Background: Folate, other vitamin B cofactors, and genes involved in folate-mediated one-carbon metabolism all may play important roles in colorectal…”
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Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome by Chau, Rowena, Dashti, Seyedeh Ghazaleh, Ait Ouakrim, Driss, Buchanan, Daniel D, Clendenning, Mark, Rosty, Christophe, Winship, Ingrid M, Young, Joanne P, Giles, Graham G, Macrae, Finlay A, Boussioutas, Alex, Parry, Susan, Figueiredo, Jane C, Levine, A Joan, Ahnen, Dennis J, Casey, Graham, Haile, Robert W, Gallinger, Steven, Le Marchand, Loïc, Thibodeau, Stephen N, Lindor, Noralane M, Newcomb, Polly A, Potter, John D, Baron, John A, Hopper, John L, Jenkins, Mark A, Win, Aung Ko

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Colorectal Adenomas in a Randomized Folate Trial: The Role of Baseline Dietary and Circulating Folate Levels by FIGUEIREDO, Jane C, LEVINE, A. Joan, MCKEOWN-EYSSEN, Gail E, SANDIER, Robert S, HAILE, Robert W, BARON, John A, GRAU, Maria V, BARRY, Elizabeth L, UELAND, Per M, AHNEN, Dennis J, BYERS, Tim, BRESALIER, Robert S, SUMMERS, Robert W, BOND, John

“…The Aspirin/Folate Polyp Prevention Study is a randomized, placebo-controlled trial of aspirin use and folic acid supplementation and incidence of colorectal…”
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Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history by Weisenberger, Daniel J, Levine, A Joan, Long, Tiffany I, Buchanan, Daniel D, Walters, Rhiannon, Clendenning, Mark, Rosty, Christophe, Joshi, Amit D, Stern, Mariana C, LeMarchand, Loic, Lindor, Noralane M, Daftary, Darshana, Gallinger, Steven, Selander, Teresa, Bapat, Bharati, Newcomb, Polly A, Campbell, Peter T, Casey, Graham, Ahnen, Dennis J, Baron, John A, Haile, Robert W, Hopper, John L, Young, Joanne P, Laird, Peter W, Siegmund, Kimberly D

“…The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG…”
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MTHFR Genotype and Colorectal Adenoma Recurrence: Data from a Double-blind Placebo-controlled Clinical Trial by LEVINE, A. Joan, WALLACE, Kristin, UELAND, Per, BARON, John A, TSANG, Shirley, HAILE, Robert W, SAIBIL, Fred, AHNEN, Dennis, COLE, Bernard F, BARRY, Elizabeth L, MUNROE, David J, ALI, Iqbal U

“…Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. We assessed the association between two common MTHFR variants, 677C>T and…”
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Folate-genetics and colorectal neoplasia: What we know and need to know next by Figueiredo, Jane C., Levine, A. Joan, Crott, Jimmy W., Baurley, James, Haile, Robert W.

“…Scope The metabolism of folate involves a complex network of polymorphic enzymes that may explain a proportion of the risk associated with colorectal…”
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Modeling Exposures for DNA Methylation Profiles by SIEGMUND, Kimberly D, LEVINE, A. Joan, JING CHANG, LAIRD, Peter W

“…We extend the finite mixture model to estimate the association between exposure and latent disease subtype measured by DNA methylation profiles. Estimates from…”
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