Search Results - "LEVIN, MARK"

The Prevalence and Prognostic Value of Low Muscle Mass in Cancer Patients: A Review of the Literature by Rier, Hánah N., Jager, Agnes, Sleijfer, Stefan, Maier, Andrea B., Levin, Mark‐David

“…In several diseases, low muscle mass has been revealed as an unfavorable prognostic factor for outcome. Whether this holds true in patients with solid…”
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Carbon-to-nitrogen single-atom transmutation of azaarenes by Woo, Jisoo, Stein, Colin, Christian, Alec H., Levin, Mark D.

“…When searching for the ideal molecule to fill a particular functional role (for example, a medicine), the difference between success and failure can often come…”
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Scaffold hopping by net photochemical carbon deletion of azaarenes by Woo, Jisoo, Christian, Alec H, Burgess, Samantha A, Jiang, Yuan, Mansoor, Umar Faruk, Levin, Mark D

“…Discovery chemists routinely identify purpose-tailored molecules through an iterative structural optimization approach, but the preparation of each successive…”
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Skeletal editing through direct nitrogen deletion of secondary amines by Kennedy, Sean H., Dherange, Balu D., Berger, Kathleen J., Levin, Mark D.

“…Synthetic chemistry aims to build up molecular complexity from simple feedstocks 1 . However, the ability to exert precise changes that manipulate the…”
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A focus on 1-azahomocubane: the new kid on the block by Elgindy, Cecile, Levin, Mark D

“…Strained hydrocarbons have recently regained interest as potential drug candidates. However, the study of their heteroatom analogs has remained limited,…”
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Gold-Catalyzed Allylation of Aryl Boronic Acids: Accessing Cross-Coupling Reactivity with Gold by Levin, Mark D., Toste, F. Dean

“…A sp3–sp2 CC cross‐coupling reaction catalyzed by gold in the absence of a sacrificial oxidant is described. Vital to the success of this method is the…”
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A supramolecular microenvironment strategy for transition metal catalysis by Kaphan, David M., Levin, Mark D., Bergman, Robert G., Raymond, Kenneth N., Toste, F. Dean

“…A self-assembled supramolecular complex is reported to catalyze alkyl-alkyl reductive elimination from high-valent transition metal complexes [such as…”
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A Synthetic Cycle for Heteroarene Synthesis by Nitride Insertion by Kelly, Patrick Q., Filatov, Alexander S., Levin, Mark D.

“…Recent interest in skeletal editing necessitates the continued development of reagent classes with the ability to transfer single atoms. Terminal transition…”
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Unified Access to Pyrimidines and Quinazolines Enabled by N–N Cleaving Carbon Atom Insertion by Hyland, Ethan E., Kelly, Patrick Q., McKillop, Alexander M., Dherange, Balu D., Levin, Mark D.

“…Given the ubiquity of heterocycles in biologically active molecules, transformations with the capacity to modify such molecular skeletons with modularity…”
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Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines by Dherange, Balu D, Kelly, Patrick Q, Liles, Jordan P, Sigman, Matthew S, Levin, Mark D

“…Herein, we report a reaction that selectively generates 3-arylpyridine and quinoline motifs by inserting aryl carbynyl cation equivalents into pyrrole and…”
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Single-atom logic for heterocycle editing by Jurczyk, Justin, Woo, Jisoo, Kim, Sojung F, Dherange, Balu D, Sarpong, Richmond, Levin, Mark D

“…Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to…”
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Aromatic nitrogen scanning by ipso -selective nitrene internalization by Pearson, Tyler J, Shimazumi, Ryoma, Driscoll, Julia L, Dherange, Balu D, Park, Dong-Il, Levin, Mark D

“…Nitrogen scanning in aryl fragments is a valuable aspect of the drug discovery process, but current strategies require time-intensive, parallel, bottom-up…”
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Photoredox Catalysis Unlocks Single-Electron Elementary Steps in Transition Metal Catalyzed Cross-Coupling by Levin, Mark D, Kim, Suhong, Toste, F. Dean

“…Since initial reports, cross-coupling technologies employing photoredox catalysts to access novel reactivity have developed with increasing pace. In this…”
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Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides by Levin, Mark D, Ovian, John M, Read, Jacquelyne A, Sigman, Matthew S, Jacobsen, Eric N

“…We report an iodoarene-catalyzed enantioselective synthesis of β,β-difluoroalkyl bromide building blocks. The transformation involves an oxidative…”
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Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of CASTOR by Spencer, Andrew, Lentzsch, Suzanne, Weisel, Katja, Avet-Loiseau, Hervé, Mark, Tomer M, Spicka, Ivan, Masszi, Tamas, Lauri, Birgitta, Levin, Mark-David, Bosi, Alberto, Hungria, Vania, Cavo, Michele, Lee, Je-Jung, Nooka, Ajay K, Quach, Hang, Lee, Cindy, Barreto, Wolney, Corradini, Paolo, Min, Chang-Ki, Scott, Emma C, Chanan-Khan, Asher A, Horvath, Noemi, Capra, Marcelo, Beksac, Meral, Ovilla, Roberto, Jo, Jae-Cheol, Shin, Ho-Jin, Sonneveld, Pieter, Soong, David, Casneuf, Tineke, Chiu, Christopher, Amin, Himal, Qi, Ming, Thiyagarajah, Piruntha, Sasser, A Kate, Schecter, Jordan M, Mateos, Maria-Victoria

“…Daratumumab, a CD38 human monoclonal antibody, demonstrated significant clinical activity in combination with bortezomib and dexamethasone versus bortezomib…”
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Fixed-duration ibrutinib–venetoclax versus chlorambucil–obinutuzumab in previously untreated chronic lymphocytic leukaemia (GLOW): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial by Niemann, Carsten U, Munir, Talha, Moreno, Carol, Owen, Carolyn, Follows, George A, Benjamini, Ohad, Janssens, Ann, Levin, Mark-David, Robak, Tadeusz, Simkovic, Martin, Voloshin, Sergey, Vorobyev, Vladimir, Yagci, Munci, Ysebaert, Loic, Qi, Keqin, Qi, Qianya, Sinet, Pierre, Parisi, Lori, Srinivasan, Srimathi, Schuier, Natasha, Baeten, Kurt, Howes, Angela, Caces, Donne Bennett, Kater, Arnon P

“…In the GLOW study, fixed-duration ibrutinib–venetoclax showed superior progression-free survival versus chlorambucil–obinutuzumab in patients with previously…”
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Direct Deamination of Primary Amines via Isodiazene Intermediates by Berger, Kathleen J, Driscoll, Julia L, Yuan, Mingbin, Dherange, Balu D, Gutierrez, Osvaldo, Levin, Mark D

“…We report here a reaction that selectively deaminates primary amines and anilines under mild conditions and with remarkable functional group tolerance…”
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Overall Survival With Daratumumab, Bortezomib, and Dexamethasone in Previously Treated Multiple Myeloma (CASTOR): A Randomized, Open-Label, Phase III Trial by Sonneveld, Pieter, Chanan-Khan, Asher, Weisel, Katja, Nooka, Ajay K, Masszi, Tamas, Beksac, Meral, Spicka, Ivan, Hungria, Vania, Munder, Markus, Mateos, Maria-Victoria, Mark, Tomer M, Levin, Mark-David, Ahmadi, Tahamtan, Qin, Xiang, Garvin Mayo, Wendy, Gai, Xue, Carey, Jodi, Carson, Robin, Spencer, Andrew

“…At the primary analysis of CASTOR (median follow-up, 7.4 months), daratumumab plus bortezomib and dexamethasone (D-Vd) significantly prolonged progression-free…”
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Direct Deaminative Functionalization by Dherange, Balu D., Yuan, Mingbin, Kelly, Christopher B., Reiher, Christopher A., Grosanu, Cristina, Berger, Kathleen J., Gutierrez, Osvaldo, Levin, Mark D.

“…Selective functional group interconversions in complex molecular settings underpin many of the challenges facing modern organic synthesis. Currently, a…”
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Survival continues to increase in chronic lymphocytic leukaemia: a population‐based analysis among 20 468 patients diagnosed in the Netherlands between 1989 and 2016 by Straten, Lina, Levin, Mark‐David, Visser, Otto, Posthuma, Eduardus F. M., Doorduijn, Jeanette K., Kater, Arnon P., Dinmohamed, Avinash G.

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