Search Results - "LEVI, A."

Genomics-Driven Oncology: Framework for an Emerging Paradigm by Garraway, Levi A

“…A majority of cancers are driven by genomic alterations that dysregulate key oncogenic pathways influencing cell growth and survival. However, the ability to…”
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Synthetic lethality as an engine for cancer drug target discovery by Huang, Alan, Garraway, Levi A., Ashworth, Alan, Weber, Barbara

“…The first wave of genetically targeted therapies for cancer focused on drugging gene products that are recurrently mutated in specific cancer types. However,…”
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Lessons from the Cancer Genome by Garraway, Levi A., Lander, Eric S.

“…Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not…”
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Graphene-Silicon Schottky Diodes by Chen, Chun-Chung, Aykol, Mehmet, Chang, Chia-Chi, Levi, A. F. J, Cronin, Stephen B

“…We have fabricated graphene-silicon Schottky diodes by depositing mechanically exfoliated graphene on top of silicon substrates. The resulting current–voltage…”
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Melanoma: from mutations to medicine by Tsao, Hensin, Chin, Lynda, Garraway, Levi A, Fisher, David E

“…Melanoma is often considered one of the most aggressive and treatment-resistant human cancers. It is a disease that, due to the presence of melanin pigment,…”
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A Convergence-Based Framework for Cancer Drug Resistance by Konieczkowski, David J., Johannessen, Cory M., Garraway, Levi A.

“…Despite advances in cancer biology and therapeutics, drug resistance remains problematic. Resistance is often multifactorial, heterogeneous, and prone to…”
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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing by Imielinski, Marcin, Berger, Alice H., Hammerman, Peter S., Hernandez, Bryan, Pugh, Trevor J., Hodis, Eran, Cho, Jeonghee, Suh, James, Capelletti, Marzia, Sivachenko, Andrey, Sougnez, Carrie, Auclair, Daniel, Lawrence, Michael S., Stojanov, Petar, Cibulskis, Kristian, Choi, Kyusam, de Waal, Luc, Sharifnia, Tanaz, Brooks, Angela, Greulich, Heidi, Banerji, Shantanu, Zander, Thomas, Seidel, Danila, Leenders, Frauke, Ansén, Sascha, Ludwig, Corinna, Engel-Riedel, Walburga, Stoelben, Erich, Wolf, Jürgen, Goparju, Chandra, Thompson, Kristin, Winckler, Wendy, Kwiatkowski, David, Johnson, Bruce E., Jänne, Pasi A., Miller, Vincent A., Pao, William, Travis, William D., Pass, Harvey I., Gabriel, Stacey B., Lander, Eric S., Thomas, Roman K., Garraway, Levi A., Getz, Gad, Meyerson, Matthew

“…Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report…”
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Precision oncology: an overview by Garraway, Levi A, Verweij, Jaap, Ballman, Karla V

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Quantitative Proteomics of the Cancer Cell Line Encyclopedia by Nusinow, David P., Szpyt, John, Ghandi, Mahmoud, Rose, Christopher M., McDonald, E. Robert, Kalocsay, Marian, Jané-Valbuena, Judit, Gelfand, Ellen, Schweppe, Devin K., Jedrychowski, Mark, Golji, Javad, Porter, Dale A., Rejtar, Tomas, Wang, Y. Karen, Kryukov, Gregory V., Stegmeier, Frank, Erickson, Brian K., Garraway, Levi A., Sellers, William R., Gygi, Steven P.

“…Proteins are essential agents of biological processes. To date, large-scale profiling of cell line collections including the Cancer Cell Line Encyclopedia…”
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Circumventing cancer drug resistance in the era of personalized medicine by Garraway, Levi A, Jänne, Pasi A

“…All successful cancer therapies are limited by the development of drug resistance. The increase in the understanding of the molecular and biochemical bases of…”
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Long-term neurocognitive effects of antipsychotics in schizophrenia: a network meta-analysis by Désaméricq, G., Schurhoff, F., Meary, A., Szöke, A., Macquin-Mavier, I., Bachoud-Lévi, A. C., Maison, P.

“…Purpose Most schizophrenic patients have mild to moderate cognitive impairment in the early stages of schizophrenia. The aim was to compare the long-term…”
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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma by Giannakis, Marios, Mu, Xinmeng Jasmine, Shukla, Sachet A., Qian, Zhi Rong, Cohen, Ofir, Nishihara, Reiko, Bahl, Samira, Cao, Yin, Amin-Mansour, Ali, Yamauchi, Mai, Sukawa, Yasutaka, Stewart, Chip, Rosenberg, Mara, Mima, Kosuke, Inamura, Kentaro, Nosho, Katsuhiko, Nowak, Jonathan A., Lawrence, Michael S., Giovannucci, Edward L., Chan, Andrew T., Ng, Kimmie, Meyerhardt, Jeffrey A., Van Allen, Eliezer M., Getz, Gad, Gabriel, Stacey B., Lander, Eric S., Wu, Catherine J., Fuchs, Charles S., Ogino, Shuji, Garraway, Levi A.

“…Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome…”
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Highly Recurrent TERT Promoter Mutations in Human Melanoma by Huang, Franklin W., Hodis, Eran, Xu, Mary Jue, Kryukov, Gregory V., Chin, Lynda, Garraway, Levi A.

“…Systematic sequencing of human cancer genomes has identified many recurrent mutations in the protein-coding regions of genes but rarely in gene regulatory…”
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines by Yu, Channing, Mannan, Aristotle M, Yvone, Griselda Metta, Ross, Kenneth N, Zhang, Yan-Ling, Marton, Melissa A, Taylor, Bradley R, Crenshaw, Andrew, Gould, Joshua Z, Tamayo, Pablo, Weir, Barbara A, Tsherniak, Aviad, Wong, Bang, Garraway, Levi A, Shamji, Alykhan F, Palmer, Michelle A, Foley, Michael A, Winckler, Wendy, Schreiber, Stuart L, Kung, Andrew L, Golub, Todd R

“…A method called PRISM rapidly identifies drug candidates that are effective against specific cancer cell lines. Hundreds of genetically characterized cell…”
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma by Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Shukla, Sachet A., Blank, Christian, Zimmer, Lisa, Sucker, Antje, Hillen, Uwe, Foppen, Marnix H. Geukes, Goldinger, Simone M., Utikal, Jochen, Hassel, Jessica C., Weide, Benjamin, Kaehler, Katharina C., Loquai, Carmen, Mohr, Peter, Gutzmer, Ralf, Dummer, Reinhard, Gabriel, Stacey, Wu, Catherine J., Schadendorf, Dirk, Garraway, Levi A.

“…Monoclonal antibodies directed against cytotoxic T lymphocyte–associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for…”
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The landscape of cancer cell line metabolism by Li, Haoxin, Ning, Shaoyang, Ghandi, Mahmoud, Kryukov, Gregory V., Gopal, Shuba, Deik, Amy, Souza, Amanda, Pierce, Kerry, Keskula, Paula, Hernandez, Desiree, Ann, Julie, Shkoza, Dojna, Apfel, Verena, Zou, Yilong, Vazquez, Francisca, Barretina, Jordi, Pagliarini, Raymond A., Galli, Giorgio G., Root, David E., Hahn, William C., Tsherniak, Aviad, Giannakis, Marios, Schreiber, Stuart L., Clish, Clary B., Garraway, Levi A., Sellers, William R.

“…Despite considerable efforts to identify cancer metabolic alterations that might unveil druggable vulnerabilities, systematic characterizations of metabolism…”
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Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer by Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V S K, Varambally, Sooryanarayana, Tomlins, Scott A, Nanus, David M, Tagawa, Scott T, Van Allen, Eliezer M, Elemento, Olivier, Sboner, Andrea, Garraway, Levi A, Rubin, Mark A, Demichelis, Francesca

“…Genome-wide DNA methylation analysis of metastatic biopsies from patients with castration-resistant prostate cancer reveals marked epigenetic differences…”
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Clinical Implications of the Cancer Genome by MACCONAILL, Laura E, GARRAWAY, Levi A

“…Cancer is a disease of the genome. Most tumors harbor a constellation of structural genomic alterations that may dictate their clinical behavior and treatment…”
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Chemical Antibody Mimics Inhibit Cadherin‐Mediated Cell–Cell Adhesion: A Promising Strategy for Cancer Therapy by Medina Rangel, Paulina X., Moroni, Elena, Merlier, Franck, Gheber, Levi A., Vago, Razi, Tse Sum Bui, Bernadette, Haupt, Karsten

“…One of the most promising strategies to treat cancer is the use of therapeutic antibodies that disrupt cell–cell adhesion mediated by dysregulated cadherins…”
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A High-pressure Filled Ice in the H2O–CO2–CH4 System, with Possible Consequences for the CO2–CH4 Biosignature Pair by Levi, A., Bansal, A., Sasselov, D.

“…Here we constrain the speciation of carbon that may outgas in ocean exoplanets. Ocean exoplanets likely have at least a few percent by mass of water, which is…”
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