Inhibition of Nitric Oxide Synthase Blocks Osteoclastic Bone Resorption in Adaptive Bone Modeling

In this study, the auditory bulla of the gerbil was pressurized, leading to active modeling of the bone of the bulla wall with a significant increase in osteoclast surface and mineral apposition rate. Systemic infusion of L-NG-nitro-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide syntha...

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Bibliographic Details
Published in:	Acta oto-laryngologica Vol. 118; no. 5; pp. 705 - 711
Main Authors:	CHOLE, R. A, TINLING, S. P, LEVERENTZ, E, MCGINN, M. D
Format:	Journal Article
Language:	English
Published:	Stockholm Informa UK Ltd 1998 Taylor & Francis Taylor and Francis
Subjects:	Adaptation, Physiological - drug effects Animals Biological and medical sciences Bone Remodeling - drug effects Bone Remodeling - physiology Bone Resorption - enzymology Bone Resorption - physiopathology Bulla Depression, Chemical Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Middle - drug effects Ear, Middle - enzymology Ear, Middle - physiology Enzyme Inhibitors - pharmacology Gerbillinae Male Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Non tumoral diseases Otorhinolaryngology. Stomatology Pressure Space life sciences Temporal bone Pathophysiology Enzyme Induction Rodentia Resorption Osteoclast Synthase Experimental study Vertebrata Mammalia Animal Nitric oxide ENT disease Inhibition Gerbil
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Summary:	In this study, the auditory bulla of the gerbil was pressurized, leading to active modeling of the bone of the bulla wall with a significant increase in osteoclast surface and mineral apposition rate. Systemic infusion of L-NG-nitro-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), inhibited this modeling process. The percentage osteoclast surface (Oc.S/BS) on the inner surface bulla wall was significantly reduced in the L-NAME-treated animals when compared with pressurized saline-treated bullae. Fluorescent bone surface (BSf) mineral apposition rates (MAR) and bone formation rate (BFR) were not significantly different in the pressurized bullae when the L-NAME group was compared with the control (vehicle only) group. However, L-NAME significantly suppressed BSf in the unpressurized bullae. Therefore, it is likely that nitric oxide is a mediator of osteoclastic resorption due to adaptive bone modeling through one or more of the isoforms of NOS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0001-6489 1651-2251
DOI:	10.1080/00016489850183223