Search Results - "LEVER, Colin"

Space in the brain: how the hippocampal formation supports spatial cognition by Hartley, Tom, Lever, Colin, Burgess, Neil, O'Keefe, John

“…Over the past four decades, research has revealed that cells in the hippocampal formation provide an exquisitely detailed representation of an animal's current…”
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Boundary Vector Cells in the Subiculum of the Hippocampal Formation by Lever, Colin, Burton, Stephen, Jeewajee, Ali, O'Keefe, John, Burgess, Neil

“…"Boundary vector cells" were predicted to exist by computational models of the environmental inputs underlying the spatial firing patterns of hippocampal place…”
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Vector trace cells in the subiculum of the hippocampal formation by Poulter, Steven, Lee, Sang Ah, Dachtler, James, Wills, Thomas J., Lever, Colin

“…Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals…”
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Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine by Douchamps, Vincent, Jeewajee, Ali, Blundell, Pam, Burgess, Neil, Lever, Colin

“…The formation of new memories requires new information to be encoded in the face of proactive interference from the past. Two solutions have been proposed for…”
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Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors by Korotkova, Tatiana, Ponomarenko, Alexey, Monaghan, Caitlin K., Poulter, Steven L., Cacucci, Francesca, Wills, Tom, Hasselmo, Michael E., Lever, Colin

“…•Theta rhythm is crucial for cognitive functions: memory, spatial and time coding.•Theta rhythm is crucial for anxiety-related behaviours.•Theta oscillation…”
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Boundary coding in the rat subiculum by Stewart, Sarah, Jeewajee, Ali, Wills, Thomas J., Burgess, Neil, Lever, Colin

“…The spatial mapping function of the hippocampal formation is likely derived from two sets of information: one based on the external environment and the other…”
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Attractor Dynamics in the Hippocampal Representation of the Local Environment by Wills, Tom J, Lever, Colin, Cacucci, Francesca, Burgess, Neil, O'Keefe, John

“…Memories are thought to be attractor states of neuronal representations, with the hippocampus a likely substrate for context-dependent episodic memories…”
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Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory by Hines, Miranda, Poulter, Steven, Douchamps, Vincent, Pibiri, Francesca, McGregor, Anthony, Lever, Colin

“…Hippocampal theta frequency is a somewhat neglected topic relative to theta power, phase, coherence, and cross-frequency coupling. Accordingly, here we review…”
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P8 Both good sleep quality and better psychological health predict reduced long-term forgetting of verbal episodic memory by Avery, Mark, Lever, Colin, Wiese, Holger

“…IntroductionGood sleep is thought to facilitate memory consolidation, yet its potential role in long-term memory (e.g., 2 weeks after the learning event) is…”
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En route to delineating hippocampal roles in spatial learning by Poulter, Steven, Austen, Joseph M., Kosaki, Yutaka, Dachtler, James, Lever, Colin, McGregor, Anthony

“…[Display omitted] The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One…”
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Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours by Pervolaraki, Eleftheria, Hall, Stephen P, Foresteire, Denise, Saito, Takashi, Saido, Takaomi C, Whittington, Miles A, Lever, Colin, Dachtler, James

“…We studied a new amyloid-beta precursor protein ( ) knock-in mouse model of Alzheimer's disease ( ), containing the Swedish KM670/671NL mutation, the Iberian…”
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Long-term plasticity in hippocampal place-cell representation of environmental geometry by Lever, Colin, O'Keefe, John, Wills, Tom, Cacucci, Francesca, Burgess, Neil

“…The hippocampus is widely believed to be involved in the storage or consolidation of long-term memories. Several reports have shown short-term changes in…”
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Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats by Pentkowski, Nathan S., Blanchard, D. Caroline, Lever, Colin, Litvin, Yoav, Blanchard, Robert J.

“…This study investigated the role of the hippocampus in both unconditioned and conditioned defensive behaviors by examining the effects of pretraining ibotenic…”
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Allocentric Spatial Memory Testing Predicts Conversion from Mild Cognitive Impairment to Dementia: An Initial Proof-of-Concept Study by Wood, Ruth A, Moodley, Kuven K, Lever, Colin, Minati, Ludovico, Chan, Dennis

“…The hippocampus is one of the first regions to exhibit neurodegeneration in Alzheimer's disease (AD), and knowledge of its role in allocentric spatial memory…”
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Theta-Modulated Place-by-Direction Cells in the Hippocampal Formation in the Rat by Cacucci, Francesca, Lever, Colin, Wills, Thomas J, Burgess, Neil, O'Keefe, John

“…We report the spatial and temporal properties of a class of cells termed theta-modulated place-by-direction (TPD) cells recorded from the presubicular and…”
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The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice by Pervolaraki, Eleftheria, Tyson, Adam L, Pibiri, Francesca, Poulter, Steven L, Reichelt, Amy C, Rodgers, R John, Clapcote, Steven J, Lever, Colin, Andreae, Laura C, Dachtler, James

“…Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of…”
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The Neurobiology of Mammalian Navigation by Poulter, Steven, Hartley, Tom, Lever, Colin

“…Mammals have evolved specialized brain systems to support efficient navigation within diverse habitats and over varied distances, but while navigational…”
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A specific role for septohippocampal acetylcholine in memory? by Easton, Alexander, Douchamps, Vincent, Eacott, Madeline, Lever, Colin

“…Acetylcholine has long been implicated in memory, including hippocampal-dependent memory, but the specific role for this neurotransmitter is difficult to…”
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Know your limits: the role of boundaries in the development of spatial representation by Hartley, Tom, Lever, Colin

“…In this issue of Neuron,Bjerknes et al. (2014) show that cells responding to environmental boundaries (border/boundary cells) are present as soon as rat pups…”
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Which memory task for my mouse? A systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse model by Stewart, Sarah, Cacucci, Francesca, Lever, Colin

“…We review studies testing performance on tasks putatively tapping spatial memory in the Tg2576 mouse model of Alzheimer's disease (AD). This model exhibits…”
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