Search Results - "LEVENBOOK, I"

Safety and Efficacy of Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine Formulations in Nonhuman Primates by GUIRAKHOO, F, PUGACHEV, K, BROWN, N, BRANDLER, S, FOURNIER, C, BARRERE, B, RIZVI, F, TRAVASSOS, A, NICHOLS, R, TRENT, D, MONATH, T, ZHANG, Z, MYERS, G, LEVENBOOK, I, DRAPER, K, LANG, J, OCRAN, S, MITCHELL, F, PARSONS, M

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Chimeric Yellow Fever Virus 17D-Japanese Encephalitis Virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing in Rhesus Monkeys by Monath, T P, Levenbook, I, Soike, K, Zhang, Z X, Ratterree, M, Draper, K, Barrett, A D, Nichols, R, Weltzin, R, Arroyo, J, Guirakhoo, F

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A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys by GUIRAKHOO, F, ZHANG, Z, LANG, J, FOURNIER, C, BARRERE, B, DELAGRAVE, S, MONATH, T. P, MYERS, G, JOHNSON, B. W, PUGACHEV, K, NICHOLS, R, BROWN, N, LEVENBOOK, I, DRAPER, K, CYREK, S

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Recombinant, chimaeric live, attenuated vaccine (ChimeriVax™) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates by Monath, T.P, Soike, K, Levenbook, I, Zhang, Z.-X, Arroyo, J, Delagrave, S, Myers, G, Barrett, A.D.T, Shope, R.E, Ratterree, M, Chambers, T.J, Guirakhoo, F

“…Yellow fever 17D virus, a safe and effective live, attenuated vaccine, was used as a vector for genes encoding the protective antigenic determinants of a…”
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Correlation Between Amount of Virus with Altered Nucleotide Sequence and the Monkey Test for Acceptability of Oral Poliovirus Vaccine by Chumakov, Konstantin M., Powers, Laurie B., Noonan, Kevin E., Roninson, Igor B., Levenbook, Inessa S.

“…Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in…”
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Safety testing for neurovirulence of novel live, attenuated flavivirus vaccines: Infant mice provide an accurate surrogate for the test in monkeys by Monath, Thomas P., Myers, Gwendolyn A., Beck, Robert A., Knauber, Michael, Scappaticci, Kelly, Pullano, Thad, Tad Archambault, W., Catalan, John, Miller, Chuck, Zhang, Zhen-Xi, Shin, Sunheang, Pugachev, Konstantin, Draper, Ken, Levenbook, Inessa S., Guirakhoo, Farshad

“…Current requirements for control of live viral vaccines, including yellow fever 17D, produced from potentially neurotropic wild-type viruses include tests for…”
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RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence by CHUMAKOV, K. M, NORWOOD, L. P, PARKER, M. L, DRAGUNSKY, E. M, YUXIN RAN, LEVENBOOK, I. S

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Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine by Rezapkin, G V, Chumakov, K M, Lu, Z, Ran, Y, Dragunsky, E M, Levenbook, I S

“…Mutants consistently accumulating in Sabin 1 poliovirus during serial passaging in vitro were identified by sequence heterogeneity assay and quantitated using…”
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Inactivated Poliovirus Vaccine Protects Transgenic Poliovirus Receptor Mice against Type 3 Poliovirus Challenge by Taffs, Rolf E., Chernokhvostova, Yelena V., Dragunsky, Eugenia M., Nomura, Tatsuji, Hioki, Kyoji, Beuvery, E. Coen, Fitzgerald, Edward A., Levenbook, Inessa S., Asher, David M.

“…Transgenic (Tg) mice expressing the human poliovirus receptor (PVR) were vaccinated with inactivated poliovirus vaccine (IPV) and evaluated for induced…”
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TgPVR21 mice for testing type-3 oral poliovirus vaccines: role of clinical observation and histological examination by Dragunsky, E., Chernokhvostova, Y., Taffs, R., Chumakov, K., Gardner, D., Asher, D., Nomura, T., Hioki, K., Levenbook, I.

“…Transgenic mice susceptible to poliovirus (TgPVR mice) have been used to study poliovirus neurovirulence and attenuation. It was shown recently that mouse line…”
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Consistent selection of mutations in the 5'-untranslated region of oral poliovirus vaccine upon passaging in vitro by Chumakov, K M, Dragunsky, E M, Norwood, L P, Douthitt, M P, Ran, Y, Taffs, R E, Ridge, J, Levenbook, I S

“…We have previously found that upon passaging type 3 oral poliovirus vaccine (OPV) in cell cultures the proportion of revertants at nucleotide 472 rapidly…”
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Limited genetic changes in the Sabin 1 strain of poliovirus occurring in the central nervous system of monkeys by Lu, Zhengbin, Rezapkin, Gennady V, Douthitt, Monica P, Ran, Yuxin, Asher, David M, Levenbook, Inessa S, Chumakov, Konstantin M

“…Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-255 1401 Rockville Pike, Rockville, MD 20852, USA Replication of attenuated…”
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Propagation and properties of Kaposi's sarcoma-derived cell lines obtained from patients with AIDS: similarity of cultured cells to smooth muscle cells by Wittek, A E, Mitchell, C D, Armstrong, G R, Albini, A, Martin, G R, Seemann, R, Levenbook, I S, Wierenga, D E, Ridge, J, Dunlap, R C

“…Cells derived from Kaposi's sarcoma (KS) were propagated in vitro using conditions which resulted in elimination of contaminating fibroblasts and the emergence…”
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Ultrastructure of virus-induced soft-tissue tumours by Levenbook, I S, Kolomiyets, O L

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Genetic Stability and Mutant Selection in Sabin 2 Strain of Oral Poliovirus Vaccine Grown under Different Cell Culture Conditions by Taffs, Rolf E., Chumakov, Konstantin M., Rezapkin, Gennady V., Lu, Zhengbin, Douthitt, Monica, Dragunsky, Eugenia M., Levenbook, Inessa S.

“…Mutations that consistently accumulated in the attenuated Sabin 2 strain of poliovirus during propagation in cell cultures were identified by sequence…”
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Microevolution of Type 3 Sabin Strain of Poliovirus in Cell Cultures and Its Implications for Oral Poliovirus Vaccine Quality Control by Rezapkin, Gennady V., Norwood, Laurie P., Taffs, Rolf E., Dragunsky, Eugenia M., Levenbook, Inessa S., Chumakov, Konstantin M.

“…Screening for sequence heterogeneities in Sabin Type 3 strains of attenuated poliovirus demonstrated mutations that consistently accumulate to significant…”
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Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines by Monath, Thomas P, Arroyo, Juan, Levenbook, Inessa, Zhang, Zhen-Xi, Catalan, John, Draper, Ken, Guirakhoo, Farshad

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Monoclonal antibodies to a rat colon carcinoma: model for monoclonal antibody therapy of solid tumors by DOUILLARD, J. Y, LABORDA, J, BURG, C, RIDGE, J, LEVENBOOK, I, BLOTTIERE, H, BEN AMI, S, HOFFMAN, T

“…Tumor progression, lung metastasis, and death occur in tumor-bearing BD IX syngeneic rats in a fashion similar to the course of patients with metastatic colon…”
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Experimental evaluation of antitoxic protective effect of new cholera vaccines in mice by Dragunsky, E M, Rivera, E, Aaronson, W, Dolgaya, T M, Hochstein, H D, Habig, W H, Levenbook, I S

“…Intraperitoneal immunization of mice and subsequent challenge with purified cholera toxin (CT) were employed to evaluate the anti-cholera toxin protective…”
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In vitro characterization of Salmonella typhi mutant strains for live oral vaccines by Dragunsky, E M, Rivera, E, Hochstein, H D, Levenbook, I S

“…Several Salmonella typhi attenuated mutant strains, suggested as candidates for live oral vaccine, were examined for their characteristics in vitro in…”
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