Search Results - "LEVCHENKO, Andre"

Topotaxis: A New Mechanism of Directed Cell Migration in Topographic ECM Gradients by Park, JinSeok, Kim, Deok-Ho, Levchenko, Andre

“…Living cells orient the cytoskeleton polarity and directional migration in response to spatial gradients of multiple types of cues. The resulting tactic…”
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Liquid and vapor phase adsorption of BTX in lignin derived activated carbon: Equilibrium and kinetics study by Saha, Dipendu, Mirando, Nathan, Levchenko, Andre

“…Benzene, toluene and xylene (BTX) are few of the chemicals that cause environmental pollution in both liquid and vapor phase. In vapor phase, they are…”
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Limits to the precision of gradient sensing with spatial communication and temporal integration by Mugler, Andrew, Levchenko, Andre, Nemenman, Ilya

“…Gradient sensing requires at least two measurements at different points in space. These measurements must then be communicated to a common location to be…”
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Information Transduction Capacity of Noisy Biochemical Signaling Networks by Cheong, Raymond, Rhee, Alex, Wang, Chiaochun Joanne, Nemenman, Ilya, Levchenko, Andre

“…Molecular noise restricts the ability of an individual cell to resolve input signals of different strengths and gather information about the external…”
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Self-induced mechanical stress can trigger biofilm formation in uropathogenic Escherichia coli by Chu, Eric K., Kilic, Onur, Cho, Hojung, Groisman, Alex, Levchenko, Andre

“…Bacterial biofilms represent an important medical problem; however, the mechanisms of the onset of biofilm formation are poorly understood. Here, using new…”
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Matrix nanotopography as a regulator of cell function by Kim, Deok-Ho, Provenzano, Paolo P, Smith, Chris L, Levchenko, Andre

“…The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to…”
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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis by Mukherjee, Radha, Vanaja, Kiran G, Boyer, Jacob A, Gadal, Sunyana, Solomon, Hilla, Chandarlapaty, Sarat, Levchenko, Andre, Rosen, Neal

“…The PI3K pathway regulates cell metabolism, proliferation, and migration, and its dysregulation is common in cancer. We now show that both physiologic and…”
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Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases by Park, JinSeok, Kim, Deok-Ho, Shah, Sagar R., Kim, Hong-Nam, Kshitiz, Kim, Peter, Quiñones-Hinojosa, Alfredo, Levchenko, Andre

“…Collective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding…”
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Directed migration of cancer cells guided by the graded texture of the underlying matrix by Park, JinSeok, Kim, Deok-Ho, Kim, Hong-Nam, Wang, Chiaochun Joanne, Kwak, Moon Kyu, Hur, Eunmi, Suh, Kahp-Yang, An, Steven S., Levchenko, Andre

“…Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define key developmental, physiological and pathological processes. Here,…”
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Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration by Lin, Benjamin, Yin, Taofei, Wu, Yi I., Inoue, Takanari, Levchenko, Andre

“…Directed cell migration in native environments is influenced by multiple migratory cues. These cues may include simultaneously occurring attractive soluble…”
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Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs by Kim, Deok-Ho, Lipke, Elizabeth A, Kim, Pilnam, Cheong, Raymond, Thompson, Susan, Delannoy, Michael, Suh, Kahp-Yang, Tung, Leslie, Levchenko, Andre

“…Heart tissue possesses complex structural organization on multiple scales, from macro- to nano-, but nanoscale control of cardiac function has not been…”
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Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway by Conlon, Patrick, Gelin-Licht, Rita, Ganesan, Ambhighainath, Zhang, Jin, Levchenko, Andre

“…In response to pheromones, yeast cells activate a MAPK pathway to direct processes important for mating, including gene induction, cell-cycle arrest, and…”
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Cell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis by Ellison, David, Mugler, Andrew, Brennan, Matthew D., Lee, Sung Hoon, Huebner, Robert J., Shamir, Eliah R., Woo, Laura A., Kim, Joseph, Amar, Patrick, Nemenman, Ilya, Ewald, Andrew J., Levchenko, Andre

“…Collective cell responses to exogenous cues depend on cell–cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli…”
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Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis by Kilic, Onur, Pamies, David, Lavell, Emily, Schiapparelli, Paula, Feng, Yun, Hartung, Thomas, Bal-Price, Anna, Hogberg, Helena T, Quinones-Hinojosa, Alfredo, Guerrero-Cazares, Hugo, Levchenko, Andre

“…Migration of neural progenitors in the complex tissue environment of the central nervous system is not well understood. Progress in this area has the potential…”
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A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns by Holmes, William R, Park, JinSeok, Levchenko, Andre, Edelstein-Keshet, Leah

“…Protrusion and retraction of lamellipodia are common features of eukaryotic cell motility. As a cell migrates through its extracellular matrix (ECM),…”
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Microengineered platforms for cell mechanobiology by Kim, Deok-Ho, Wong, Pak Kin, Park, Jungyul, Levchenko, Andre, Sun, Yu

“…Mechanical forces play important roles in the regulation of various biological processes at the molecular and cellular level, such as gene expression,…”
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Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters by Rhee, Alex, Cheong, Raymond, Levchenko, Andre

“…Significance In response to a uniform stimulus, biochemical networks display a high degree of variability when assayed across many individual cells. However,…”
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How Information Theory Handles Cell Signaling and Uncertainty by Brennan, Matthew D., Cheong, Raymond, Levchenko, Andre

“…Information theory allows analyses of cell signaling capabilities without necessarily requiring detailed knowledge of the signaling networks. Intracellular…”
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Understanding NF-κB signaling via mathematical modeling by Hoffmann, Alexander, Levchenko, Andre, Cheong, Raymond

“…Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be…”
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Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome by Raredon, Micha Sam Brickman, Yang, Junchen, Garritano, James, Wang, Meng, Kushnir, Dan, Schupp, Jonas Christian, Adams, Taylor S., Greaney, Allison M., Leiby, Katherine L., Kaminski, Naftali, Kluger, Yuval, Levchenko, Andre, Niklason, Laura E.

“…Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the…”
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