Search Results - "LETAI, Anthony"

Functional precision cancer medicine—moving beyond pure genomics by Letai, Anthony

“…Anthony Letai proposes wider adoption of functional assays in efforts to match the right drug to the right patient and discusses why these assays might be…”
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S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver by Letai, Anthony

“…A recent study reports a novel small molecule inhibitor of MCL-1 with efficacy in killing MCL-1-dependent cancer cells in vitro and in vivo. With the advent of…”
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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins by Singh, Rumani, Letai, Anthony, Sarosiek, Kristopher

“…The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including…”
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Apoptosis and Cancer by Letai, Anthony

“…Cancer is a disease involving the abnormal accumulation of cells resulting from an imbalance of proliferation and programmed cell death. This review focuses on…”
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Diagnosing and exploiting cancer's addiction to blocks in apoptosis by Letai, Anthony G

“…Key Points Cancer cells exhibit many phenotypes, such as genomic instability or oncogene activation, that ought to induce apoptosis, but they nonetheless…”
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BH3 profiling in whole cells by fluorimeter or FACS by Ryan, Jeremy, Letai, Anthony

“…•Functional assay reports mitochondrial response without knowledge of protein levels.•Plate reader assay is suitable for large sample numbers for homogenous…”
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Control of mitochondrial apoptosis by the Bcl-2 family by Brunelle, Joslyn K, Letai, Anthony

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Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer by DAVIDS, Matthew S, LETAI, Anthony

“…The B-cell lymphoma/leukemia 2 (BCL-2) family of proteins has attracted the attention of cancer biologists since the cloning of BCL-2 more than 25 years ago…”
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iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry by Ryan, Jeremy, Montero, Joan, Rocco, James, Letai, Anthony

“…Dysregulation of the mitochondrial pathway of apoptosis, controlled by the BCL-2 family of proteins, leads to disease states including cancer. Rapid analysis…”
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BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions by Del Gaizo Moore, Victoria, Letai, Anthony

“…Abstract Apoptosis is a form of programmed cell death that is controlled at the mitochondrion by the BCL-2 family of proteins. While much has been learned…”
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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia by DiNardo, Courtney D, Jonas, Brian A, Pullarkat, Vinod, Thirman, Michael J, Garcia, Jacqueline S, Wei, Andrew H, Konopleva, Marina, Döhner, Hartmut, Letai, Anthony, Fenaux, Pierre, Koller, Elizabeth, Havelange, Violaine, Leber, Brian, Esteve, Jordi, Wang, Jianxiang, Pejsa, Vlatko, Hájek, Roman, Porkka, Kimmo, Illés, Árpád, Lavie, David, Lemoli, Roberto M, Yamamoto, Kazuhito, Yoon, Sung-Soo, Jang, Jun-Ho, Yeh, Su-Peng, Turgut, Mehmet, Hong, Wan-Jen, Zhou, Ying, Potluri, Jalaja, Pratz, Keith W

“…In more than 400 older patients with AML who could not receive myeloablative therapy, the incidence of composite complete remission was higher (66.4% vs. 28.3)…”
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Puma strikes Bax by Letai, Anthony

“…The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue,…”
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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia by Pan, Rongqing, Hogdal, Leah J, Benito, Juliana M, Bucci, Donna, Han, Lina, Borthakur, Gautam, Cortes, Jorge, DeAngelo, Daniel J, Debose, Lakeisha, Mu, Hong, Döhner, Hartmut, Gaidzik, Verena I, Galinsky, Ilene, Golfman, Leonard S, Haferlach, Torsten, Harutyunyan, Karine G, Hu, Jianhua, Leverson, Joel D, Marcucci, Guido, Müschen, Markus, Newman, Rachel, Park, Eugene, Ruvolo, Peter P, Ruvolo, Vivian, Ryan, Jeremy, Schindela, Sonja, Zweidler-McKay, Patrick, Stone, Richard M, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina, Letai, Anthony G

“…B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that are…”
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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies by Guièze, Romain, Liu, Vivian M., Rosebrock, Daniel, Jourdain, Alexis A., Hernández-Sánchez, María, Martinez Zurita, Aina, Sun, Jing, Ten Hacken, Elisa, Baranowski, Kaitlyn, Thompson, Philip A., Heo, Jin-Mi, Cartun, Zachary, Aygün, Ozan, Iorgulescu, J. Bryan, Zhang, Wandi, Notarangelo, Giulia, Livitz, Dimitri, Li, Shuqiang, Davids, Matthew S., Biran, Anat, Fernandes, Stacey M., Brown, Jennifer R., Lako, Ana, Ciantra, Zoe B., Lawlor, Matthew A., Keskin, Derin B., Udeshi, Namrata D., Wierda, William G., Livak, Kenneth J., Letai, Anthony G., Neuberg, Donna, Harper, J. Wade, Carr, Steven A., Piccioni, Federica, Ott, Christopher J., Leshchiner, Ignaty, Johannessen, Cory M., Doench, John, Mootha, Vamsi K., Getz, Gad, Wu, Catherine J.

“…Mitochondrial apoptosis can be effectively targeted in lymphoid malignancies with the FDA-approved B cell lymphoma 2 (BCL-2) inhibitor venetoclax, but…”
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PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells by Kahn, Josephine D., Miller, Peter G., Silver, Alexander J., Sellar, Rob S., Bhatt, Shruti, Gibson, Christopher, McConkey, Marie, Adams, Dylan, Mar, Brenton, Mertins, Philipp, Fereshetian, Shaunt, Krug, Karsten, Zhu, Haoling, Letai, Anthony, Carr, Steven A., Doench, John, Jaiswal, Siddhartha, Ebert, Benjamin L.

“…Truncating mutations in the terminal exon of protein phosphatase Mg2+/Mn2+ 1D (PPM1D) have been identified in clonal hematopoiesis and myeloid neoplasms, with…”
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Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax by Leverson, Joel D, Sampath, Deepak, Souers, Andrew J, Rosenberg, Saul H, Fairbrother, Wayne J, Amiot, Martine, Konopleva, Marina, Letai, Anthony

“…Since the discovery of apoptosis as a form of programmed cell death, targeting the apoptosis pathway to induce cancer cell death has been a high-priority goal…”
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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance by Kale, Justin, Kutuk, Ozgur, Brito, Glauber Costa, Andrews, Tallulah S, Leber, Brian, Letai, Anthony, Andrews, David W

“…Akt is a pro‐survival kinase frequently activated in human cancers and is associated with more aggressive tumors that resist therapy. Here, we connect Akt…”
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Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy by Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony

“…There is a lack of effective predictive biomarkers to precisely assign optimal therapy to cancer patients. While most efforts are directed at inferring drug…”
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BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents by Deng, Jing, Carlson, Nicole, Takeyama, Kunihiko, Dal Cin, Paola, Shipp, Margaret, Letai, Anthony

“…Cancer cells exhibit many abnormal phenotypes that induce apoptotic signaling via the intrinsic, or mitochondrial, pathway. That cancer cells nonetheless…”
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Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition by Burger, Jan A., Landau, Dan A., Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M., Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J., Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R., Abruzzo, Lynne V., Carter, Scott L., Keating, Michael J., Davids, Matthew S., Wierda, William G., Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Cin, Paola Dal, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O’Brien, Susan, Letai, Anthony, Weitz, David A., Nowak, Martin A., Getz, Gad, Wu, Catherine J.

“…Resistance to the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using…”
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